C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases

The Src family of protein kinases (SFKs) mediates mitogenic signal transduction, and constitutive SFK activation is associated with tumorigenesis. To prevent constitutive SFK activation, the catalytic activity of SFKs in normal mammalian cells is suppressed mainly by two inhibitors called C-terminal...

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Veröffentlicht in:	The Journal of biological chemistry 2006-11, Vol.281 (44), p.32988-32999
Hauptverfasser:	Chong, Yuh-Ping, Chan, Andrew S., Chan, Khai-Chew, Williamson, Nicholas A., Lerner, Edwina C., Smithgall, Thomas E., Bjorge, Jeffrey D., Fujita, Donald J., Purcell, Anthony W., Scholz, Glen, Mulhern, Terrence D., Cheng, Heung-Chin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Catalysis Cell Line Down-Regulation Enzyme Activation Humans Mutation - genetics Protein Binding Protein Conformation Spodoptera src-Family Kinases - classification src-Family Kinases - genetics src-Family Kinases - metabolism
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