Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis

Transforming growth factor- β (TGF β )-activated signalling pathways can lead to apoptosis, growth arrest or promotion of malignant behaviour, dependent on cellular context. The molecular mechanisms involved in TGF β -induced apoptosis remain controversial; although changes in gene expression are th...

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Veröffentlicht in:	Oncogene 2007-02, Vol.26 (7), p.970-981
Hauptverfasser:	Ramjaun, A R, Tomlinson, S, Eddaoudi, A, Downward, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis Adaptor Proteins, Signal Transducing - genetics Ageing, cell death Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics Bcl-2 protein Bcl-2-Like Protein 11 BH3 Interacting Domain Death Agonist Protein - biosynthesis BH3 Interacting Domain Death Agonist Protein - genetics BIM protein Biological and medical sciences Cancer Care and treatment Cell Biology Cell death Cell Line Cell Line, Tumor Cell membranes Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Health aspects Human Genetics Internal Medicine Medicine Medicine & Public Health Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Molecular and cellular biology Molecular modelling Oncology original-article Phosphotransferases Properties Proteins Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Rats Reactive oxygen species Signal transduction Smad4 protein Transcription Transforming Growth Factor beta - physiology Transforming growth factor-b Transforming growth factors Tumor suppressor genes Up-Regulation - genetics Up-Regulation - physiology
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container_title	Oncogene
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creator	Ramjaun, A R Tomlinson, S Eddaoudi, A Downward, J
description	Transforming growth factor- β (TGF β )-activated signalling pathways can lead to apoptosis, growth arrest or promotion of malignant behaviour, dependent on cellular context. The molecular mechanisms involved in TGF β -induced apoptosis remain controversial; although changes in gene expression are thought to be pivotal to the process, several different candidate apoptotic initiators and mediators have been proposed. Smad4, a critical component of the TGF β -induced transcriptional machinery, is shown here to be essential for induction of apoptosis. Gene expression analysis identified the proapoptotic Bcl-2 family members, Bmf and Bim, as induced by TGF β , dependent on both Smad4 and p38 function and the generation of reactive oxygen species. TGF β -induced Bmf and Bim localize to cellular membranes implicated in apoptosis. Inhibition of the TGF β -induced expression of both these proteins together provides significant protection of cells from apoptosis. The TGF β -triggered cell death programme thus involves induction of multiple BH3-only proteins during the induction of apoptosis.
doi_str_mv	10.1038/sj.onc.1209852
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The TGF β -triggered cell death programme thus involves induction of multiple BH3-only proteins during the induction of apoptosis.</description><subject>Adaptor Proteins, Signal Transducing - biosynthesis</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Ageing, cell death</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Apoptosis - physiology</subject><subject>Apoptosis Regulatory Proteins - biosynthesis</subject><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Bcl-2 protein</subject><subject>Bcl-2-Like Protein 11</subject><subject>BH3 Interacting Domain Death Agonist Protein - biosynthesis</subject><subject>BH3 Interacting Domain Death Agonist Protein - genetics</subject><subject>BIM protein</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Cell membranes</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. 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subjects	Adaptor Proteins, Signal Transducing - biosynthesis Adaptor Proteins, Signal Transducing - genetics Ageing, cell death Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics Bcl-2 protein Bcl-2-Like Protein 11 BH3 Interacting Domain Death Agonist Protein - biosynthesis BH3 Interacting Domain Death Agonist Protein - genetics BIM protein Biological and medical sciences Cancer Care and treatment Cell Biology Cell death Cell Line Cell Line, Tumor Cell membranes Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Health aspects Human Genetics Internal Medicine Medicine Medicine & Public Health Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Molecular and cellular biology Molecular modelling Oncology original-article Phosphotransferases Properties Proteins Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Rats Reactive oxygen species Signal transduction Smad4 protein Transcription Transforming Growth Factor beta - physiology Transforming growth factor-b Transforming growth factors Tumor suppressor genes Up-Regulation - genetics Up-Regulation - physiology
title	Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis
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