Determination of Parabens and Triclosan in Indoor Dust Using Matrix Solid-Phase Dispersion and Gas Chromatography with Tandem Mass Spectrometry
A simple sample preparation method for the determination of four parabens and triclosan in indoor dust is presented. Analytes were extracted from the sample and isolated from interfering species using the matrix solid-phase dispersion technique. After that, they were silylated and determined by gas...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2007-02, Vol.79 (4), p.1675-1681 |
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| creator | Canosa, P Rodríguez, I Rubí, E Cela, R |
| description | A simple sample preparation method for the determination of four parabens and triclosan in indoor dust is presented. Analytes were extracted from the sample and isolated from interfering species using the matrix solid-phase dispersion technique. After that, they were silylated and determined by gas chromatography combined to tandem mass spectrometry (GC/MS/MS). The influence of several factors on the yield and selectivity of the extraction was evaluated in detail. Under final working conditions, samples (0.5 g) were mixed with the same amount of anhydrous sodium sulfate and dispersed on 1.25 g of C18. This blend was transferred to the top of a polypropylene cartridge containing 2 g of Florisil. After removing less polar species with 10 mL of dichloromethane, analytes were recovered using 10 mL of acetonitrile. This extract was concentrated to 1 mL, derivatized, and injected in the GC/MS/MS system. Derivatization was carried out at 45 °C in 5 min using 100 μL of N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide. Quantification limits from 0.6 to 2.6 ng/g and absolute recoveries between 80 and 114% were achieved. Analysis of dust samples demonstrated the presence of the target species in indoor dust from private houses. The highest average concentration (702 ng/g) corresponded to triclosan. |
| doi_str_mv | 10.1021/ac061896e |
| format | Article |
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Analytes were extracted from the sample and isolated from interfering species using the matrix solid-phase dispersion technique. After that, they were silylated and determined by gas chromatography combined to tandem mass spectrometry (GC/MS/MS). The influence of several factors on the yield and selectivity of the extraction was evaluated in detail. Under final working conditions, samples (0.5 g) were mixed with the same amount of anhydrous sodium sulfate and dispersed on 1.25 g of C18. This blend was transferred to the top of a polypropylene cartridge containing 2 g of Florisil. After removing less polar species with 10 mL of dichloromethane, analytes were recovered using 10 mL of acetonitrile. This extract was concentrated to 1 mL, derivatized, and injected in the GC/MS/MS system. Derivatization was carried out at 45 °C in 5 min using 100 μL of N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide. Quantification limits from 0.6 to 2.6 ng/g and absolute recoveries between 80 and 114% were achieved. Analysis of dust samples demonstrated the presence of the target species in indoor dust from private houses. 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Chem</addtitle><description>A simple sample preparation method for the determination of four parabens and triclosan in indoor dust is presented. Analytes were extracted from the sample and isolated from interfering species using the matrix solid-phase dispersion technique. After that, they were silylated and determined by gas chromatography combined to tandem mass spectrometry (GC/MS/MS). The influence of several factors on the yield and selectivity of the extraction was evaluated in detail. Under final working conditions, samples (0.5 g) were mixed with the same amount of anhydrous sodium sulfate and dispersed on 1.25 g of C18. This blend was transferred to the top of a polypropylene cartridge containing 2 g of Florisil. After removing less polar species with 10 mL of dichloromethane, analytes were recovered using 10 mL of acetonitrile. This extract was concentrated to 1 mL, derivatized, and injected in the GC/MS/MS system. Derivatization was carried out at 45 °C in 5 min using 100 μL of N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide. Quantification limits from 0.6 to 2.6 ng/g and absolute recoveries between 80 and 114% were achieved. Analysis of dust samples demonstrated the presence of the target species in indoor dust from private houses. The highest average concentration (702 ng/g) corresponded to triclosan.</description><subject>Analytical chemistry</subject><subject>Chemical compounds</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography</subject><subject>Combinatorial Chemistry Techniques - methods</subject><subject>Dust</subject><subject>Dust - analysis</subject><subject>Exact sciences and technology</subject><subject>Extraction processes</subject><subject>Gas chromatographic methods</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>Mass spectrometry</subject><subject>Parabens - analysis</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spectrometric and optical methods</subject><subject>Triclosan - analysis</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0d-KEzEUBvBBFLeuXvgCEgQFL0aTTPNnLqXV3YUVi-2CeBPOzGS2WWeSmpPi9il8ZVNatqBXuTg_Ps7JVxQvGX3PKGcfoKWS6VraR8WECU5LqTV_XEwopVXJFaVnxTPEO0oZo0w-Lc6Y4rWqFZ8Uf-Y22Tg6D8kFT0JPFhChsR4J-I6somuHgOCJ8-TKdyFEMt9iIjfo_C35Aim6e7IMg-vKxRrQkrnDjY24D9sHXACS2TqGEVK4jbBZ78hvl9ZklYd2zAGIZLmxbcrEprh7XjzpYUD74vieFzefP61ml-X114ur2cfrEqZUp7KpVMUrqJSVqqupUvUUmFJ9p6fcMtk2qm5qKgSXjAndMG7rzopW9FJ0uuGiOi_eHnI3MfzaWkxmdNjaYQBvwxaNrCnNn8gzfP0PvAvb6PNuhjOltdBsmtG7A2pjQIy2N5voRog7w6jZV2QeKsr21TFw24y2O8ljJxm8OQLAFoY-gm8dnpwW1TQ3mV15cA6TvX-YQ_xppKqUMKvF0lTyx_eZvqTm2ykXWjwd8f-CfwHQbrPf</recordid><startdate>20070215</startdate><enddate>20070215</enddate><creator>Canosa, P</creator><creator>Rodríguez, I</creator><creator>Rubí, E</creator><creator>Cela, R</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070215</creationdate><title>Determination of Parabens and Triclosan in Indoor Dust Using Matrix Solid-Phase Dispersion and Gas Chromatography with Tandem Mass Spectrometry</title><author>Canosa, P ; Rodríguez, I ; Rubí, E ; Cela, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a408t-b37323a37e67d907794a177fd842e16cb79b9055261158b12e9de5c5f65d8b253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analytical chemistry</topic><topic>Chemical compounds</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography</topic><topic>Combinatorial Chemistry Techniques - methods</topic><topic>Dust</topic><topic>Dust - analysis</topic><topic>Exact sciences and technology</topic><topic>Extraction processes</topic><topic>Gas chromatographic methods</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>Mass spectrometry</topic><topic>Parabens - analysis</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spectrometric and optical methods</topic><topic>Triclosan - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canosa, P</creatorcontrib><creatorcontrib>Rodríguez, I</creatorcontrib><creatorcontrib>Rubí, E</creatorcontrib><creatorcontrib>Cela, R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canosa, P</au><au>Rodríguez, I</au><au>Rubí, E</au><au>Cela, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Parabens and Triclosan in Indoor Dust Using Matrix Solid-Phase Dispersion and Gas Chromatography with Tandem Mass Spectrometry</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2007-02-15</date><risdate>2007</risdate><volume>79</volume><issue>4</issue><spage>1675</spage><epage>1681</epage><pages>1675-1681</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>A simple sample preparation method for the determination of four parabens and triclosan in indoor dust is presented. Analytes were extracted from the sample and isolated from interfering species using the matrix solid-phase dispersion technique. After that, they were silylated and determined by gas chromatography combined to tandem mass spectrometry (GC/MS/MS). The influence of several factors on the yield and selectivity of the extraction was evaluated in detail. Under final working conditions, samples (0.5 g) were mixed with the same amount of anhydrous sodium sulfate and dispersed on 1.25 g of C18. This blend was transferred to the top of a polypropylene cartridge containing 2 g of Florisil. After removing less polar species with 10 mL of dichloromethane, analytes were recovered using 10 mL of acetonitrile. This extract was concentrated to 1 mL, derivatized, and injected in the GC/MS/MS system. Derivatization was carried out at 45 °C in 5 min using 100 μL of N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide. Quantification limits from 0.6 to 2.6 ng/g and absolute recoveries between 80 and 114% were achieved. Analysis of dust samples demonstrated the presence of the target species in indoor dust from private houses. The highest average concentration (702 ng/g) corresponded to triclosan.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>17297972</pmid><doi>10.1021/ac061896e</doi><tpages>7</tpages></addata></record> |
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| ispartof | Analytical chemistry (Washington), 2007-02, Vol.79 (4), p.1675-1681 |
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| subjects | Analytical chemistry Chemical compounds Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Combinatorial Chemistry Techniques - methods Dust Dust - analysis Exact sciences and technology Extraction processes Gas chromatographic methods Gas Chromatography-Mass Spectrometry - methods Mass spectrometry Parabens - analysis Reproducibility of Results Sensitivity and Specificity Spectrometric and optical methods Triclosan - analysis |
| title | Determination of Parabens and Triclosan in Indoor Dust Using Matrix Solid-Phase Dispersion and Gas Chromatography with Tandem Mass Spectrometry |
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