Autophagy delays apoptotic death in breast cancer cells following DNA damage

Early signaling in camptothecin-treated MCF-7 cells followed an intrinsic pathway, but death was delayed and late events exhibited few hallmarks of apoptosis. BH3-only proteins, such as Noxa, Puma and BimEL, were activated and localized to mitochondrial sites within 24 h following drug exposure. How...

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Veröffentlicht in:	Cell death and differentiation 2007-03, Vol.14 (3), p.500-510
Hauptverfasser:	Abedin, M J, Wang, D, McDonnell, M A, Lehmann, U, Kelekar, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Camptothecin - pharmacology Caspases - metabolism Cell Biology Cell Cycle Analysis Cell Line, Tumor DNA Damage Gene Expression Regulation, Neoplastic Humans Life Sciences original-paper Peptide Fragments - genetics Peptide Fragments - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction Stem Cells Transcription, Genetic Tumor Suppressor Protein p53 - metabolism Up-Regulation
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