Online clearance measurement in high-efficiency hemodiafiltration
The measurement of ionic dialysance by conductivity variation is an established method in diffusive hemodialysis. To extend the validity of this method for use in highly convective therapies, such as online hemodiafiltration, we derived a new model for the measurement of ionic dialysance. This metho...
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| Veröffentlicht in: | Kidney international 2007-12, Vol.72 (12), p.1550-1553 |
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| creator | Gross, M. Maierhofer, A. Tetta, C. Sénecal, L. Canaud, B. |
| description | The measurement of ionic dialysance by conductivity variation is an established method in diffusive hemodialysis. To extend the validity of this method for use in highly convective therapies, such as online hemodiafiltration, we derived a new model for the measurement of ionic dialysance. This method was validated in a study involving 12 patients on pre- and postdilution online hemodiafiltration under various conditions. Clinically, there was a very good agreement between the dialysance determined by conductivity variation and blood side urea clearance. Neither the dilution modes nor the flow rate of the substitution fluid was found to significantly influence this agreement. Our results show that ionic dialysance can be easily and precisely measured by conductivity variation, and this provides an excellent surrogate for urea clearance even in highly convective therapies. |
| doi_str_mv | 10.1038/sj.ki.5002551 |
| format | Article |
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To extend the validity of this method for use in highly convective therapies, such as online hemodiafiltration, we derived a new model for the measurement of ionic dialysance. This method was validated in a study involving 12 patients on pre- and postdilution online hemodiafiltration under various conditions. Clinically, there was a very good agreement between the dialysance determined by conductivity variation and blood side urea clearance. Neither the dilution modes nor the flow rate of the substitution fluid was found to significantly influence this agreement. 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| subjects | Biological and medical sciences clearance convection dialysis efficiency hemodiafiltration Hemodiafiltration - methods Hemodiafiltration - standards Humans Kidney Failure, Chronic - therapy Medical sciences Models, Biological Nephrology. Urinary tract diseases Reproducibility of Results Urea - metabolism |
| title | Online clearance measurement in high-efficiency hemodiafiltration |
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