Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of Duchenne muscular dystrophy
Intrinsic laryngeal muscles share many anatomical and physiological properties with extraocular muscles, which are unaffected in both Duchenne muscular dystrophy and mdx mice. We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool...
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| Veröffentlicht in: | Muscle & nerve 2007-03, Vol.35 (3), p.349-353 |
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| creator | Marques, Maria Julia Ferretti, Renato Vomero, Viviane Urbini Minatel, Elaine Neto, Humberto Santo |
| description | Intrinsic laryngeal muscles share many anatomical and physiological properties with extraocular muscles, which are unaffected in both Duchenne muscular dystrophy and mdx mice. We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool to understand the mechanisms of muscle sparing in dystrophinopathy. Intrinsic laryngeal muscles and tibialis anterior (TA) muscle of adult and aged mdx and control C57Bl/10 mice were investigated. The percentage of central nucleated fibers, as a sign of muscle fibers that had undergone injury and regeneration, and myofiber labeling with Evans blue dye, as a marker of myofiber damage, were studied. Except for the cricothyroid muscle, none of the intrinsic laryngeal muscles from adult and old mdx mice showed signs of myofiber damage or Evans blue dye labeling, and all appeared to be normal. Central nucleation was readily visible in the TA of the same mdx mice. A significant increase in the percentage of central nucleated fibers was observed in adult cricothyroid muscle compared to the other intrinsic laryngeal muscles, which worsened with age. Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy. Muscle Nerve, 2006 |
| doi_str_mv | 10.1002/mus.20697 |
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We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool to understand the mechanisms of muscle sparing in dystrophinopathy. Intrinsic laryngeal muscles and tibialis anterior (TA) muscle of adult and aged mdx and control C57Bl/10 mice were investigated. The percentage of central nucleated fibers, as a sign of muscle fibers that had undergone injury and regeneration, and myofiber labeling with Evans blue dye, as a marker of myofiber damage, were studied. Except for the cricothyroid muscle, none of the intrinsic laryngeal muscles from adult and old mdx mice showed signs of myofiber damage or Evans blue dye labeling, and all appeared to be normal. Central nucleation was readily visible in the TA of the same mdx mice. A significant increase in the percentage of central nucleated fibers was observed in adult cricothyroid muscle compared to the other intrinsic laryngeal muscles, which worsened with age. Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy. Muscle Nerve, 2006</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.20697</identifier><identifier>PMID: 17143878</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>aging ; Aging - pathology ; Animals ; Biological and medical sciences ; Cell Nucleus - pathology ; Disease Models, Animal ; Disease Progression ; Diseases of striated muscles. Neuromuscular diseases ; dystrophin ; Dystrophin - deficiency ; Evans Blue ; Fundamental and applied biological sciences. Psychology ; intrinsic laryngeal muscles ; Laryngeal Muscles - pathology ; Laryngeal Muscles - physiopathology ; Male ; mdx mouse ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Inbred mdx ; Muscle Fibers, Skeletal - metabolism ; Muscle Fibers, Skeletal - pathology ; muscle regeneration ; Muscular Dystrophy, Duchenne - pathology ; Muscular Dystrophy, Duchenne - physiopathology ; Necrosis - genetics ; Necrosis - pathology ; Necrosis - physiopathology ; Neurology ; Regeneration - physiology ; Striated muscle. 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We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool to understand the mechanisms of muscle sparing in dystrophinopathy. Intrinsic laryngeal muscles and tibialis anterior (TA) muscle of adult and aged mdx and control C57Bl/10 mice were investigated. The percentage of central nucleated fibers, as a sign of muscle fibers that had undergone injury and regeneration, and myofiber labeling with Evans blue dye, as a marker of myofiber damage, were studied. Except for the cricothyroid muscle, none of the intrinsic laryngeal muscles from adult and old mdx mice showed signs of myofiber damage or Evans blue dye labeling, and all appeared to be normal. Central nucleation was readily visible in the TA of the same mdx mice. A significant increase in the percentage of central nucleated fibers was observed in adult cricothyroid muscle compared to the other intrinsic laryngeal muscles, which worsened with age. Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy. Muscle Nerve, 2006</description><subject>aging</subject><subject>Aging - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - pathology</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>dystrophin</subject><subject>Dystrophin - deficiency</subject><subject>Evans Blue</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>intrinsic laryngeal muscles</subject><subject>Laryngeal Muscles - pathology</subject><subject>Laryngeal Muscles - physiopathology</subject><subject>Male</subject><subject>mdx mouse</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred mdx</subject><subject>Muscle Fibers, Skeletal - metabolism</subject><subject>Muscle Fibers, Skeletal - pathology</subject><subject>muscle regeneration</subject><subject>Muscular Dystrophy, Duchenne - pathology</subject><subject>Muscular Dystrophy, Duchenne - physiopathology</subject><subject>Necrosis - genetics</subject><subject>Necrosis - pathology</subject><subject>Necrosis - physiopathology</subject><subject>Neurology</subject><subject>Regeneration - physiology</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PFTEUhhsjkSu68A-YbjRxMdBOv5eCgiSoMUJw13Tajrfa6VzbmcD8ewv3Iis3p2fxnOf0vAC8wugQI9QeDXM5bBFX4glYYaREQ5mST8EKYSobTtSPffC8lF8IISy5eAb2scCUSCFXYDhPUw6pBAujyUv66U2E1WejL9BkD8umVgf7PA5wWMbkbR5LKDAkOK09HNwtHMa51G50PsKxhx9mu_Yp-XvNXK3QLWXK42a9vAB7vYnFv9y9B-Dq9OPlyafm4uvZ-cn7i8ZSJkTDCJfckb5l0iolkVUGdwIJQq1xBhPaOyd4J1nXEoqwY5S6HjuKuDTMso4cgLdb7yaPf2ZfJj2EYn2MJvn6Wc0VQgIxXMF3W_DuqpJ9rzc5DDUIjZG-y1bXI_R9tpV9vZPO3eDdI7kLswJvdoAp1sQ-m2RDeeQkU60grHJHW-4mRL_8f6P-fPX9YXWznQhl8rf_Jkz-rbkggunrL2f6El2Tb-KYa0r-AoSzoPI</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Marques, Maria Julia</creator><creator>Ferretti, Renato</creator><creator>Vomero, Viviane Urbini</creator><creator>Minatel, Elaine</creator><creator>Neto, Humberto Santo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of Duchenne muscular dystrophy</title><author>Marques, Maria Julia ; Ferretti, Renato ; Vomero, Viviane Urbini ; Minatel, Elaine ; Neto, Humberto Santo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4577-53686d3f258c9980c9a1b70734cada134fdd76b85b23401d544df1d4068a5c5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>aging</topic><topic>Aging - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Nucleus - pathology</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>dystrophin</topic><topic>Dystrophin - deficiency</topic><topic>Evans Blue</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>intrinsic laryngeal muscles</topic><topic>Laryngeal Muscles - pathology</topic><topic>Laryngeal Muscles - physiopathology</topic><topic>Male</topic><topic>mdx mouse</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred mdx</topic><topic>Muscle Fibers, Skeletal - metabolism</topic><topic>Muscle Fibers, Skeletal - pathology</topic><topic>muscle regeneration</topic><topic>Muscular Dystrophy, Duchenne - pathology</topic><topic>Muscular Dystrophy, Duchenne - physiopathology</topic><topic>Necrosis - genetics</topic><topic>Necrosis - pathology</topic><topic>Necrosis - physiopathology</topic><topic>Neurology</topic><topic>Regeneration - physiology</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Maria Julia</creatorcontrib><creatorcontrib>Ferretti, Renato</creatorcontrib><creatorcontrib>Vomero, Viviane Urbini</creatorcontrib><creatorcontrib>Minatel, Elaine</creatorcontrib><creatorcontrib>Neto, Humberto Santo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Maria Julia</au><au>Ferretti, Renato</au><au>Vomero, Viviane Urbini</au><au>Minatel, Elaine</au><au>Neto, Humberto Santo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of Duchenne muscular dystrophy</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2007-03</date><risdate>2007</risdate><volume>35</volume><issue>3</issue><spage>349</spage><epage>353</epage><pages>349-353</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Intrinsic laryngeal muscles share many anatomical and physiological properties with extraocular muscles, which are unaffected in both Duchenne muscular dystrophy and mdx mice. We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool to understand the mechanisms of muscle sparing in dystrophinopathy. Intrinsic laryngeal muscles and tibialis anterior (TA) muscle of adult and aged mdx and control C57Bl/10 mice were investigated. The percentage of central nucleated fibers, as a sign of muscle fibers that had undergone injury and regeneration, and myofiber labeling with Evans blue dye, as a marker of myofiber damage, were studied. Except for the cricothyroid muscle, none of the intrinsic laryngeal muscles from adult and old mdx mice showed signs of myofiber damage or Evans blue dye labeling, and all appeared to be normal. Central nucleation was readily visible in the TA of the same mdx mice. A significant increase in the percentage of central nucleated fibers was observed in adult cricothyroid muscle compared to the other intrinsic laryngeal muscles, which worsened with age. Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy. Muscle Nerve, 2006</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17143878</pmid><doi>10.1002/mus.20697</doi><tpages>5</tpages></addata></record> |
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| ispartof | Muscle & nerve, 2007-03, Vol.35 (3), p.349-353 |
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| subjects | aging Aging - pathology Animals Biological and medical sciences Cell Nucleus - pathology Disease Models, Animal Disease Progression Diseases of striated muscles. Neuromuscular diseases dystrophin Dystrophin - deficiency Evans Blue Fundamental and applied biological sciences. Psychology intrinsic laryngeal muscles Laryngeal Muscles - pathology Laryngeal Muscles - physiopathology Male mdx mouse Medical sciences Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology muscle regeneration Muscular Dystrophy, Duchenne - pathology Muscular Dystrophy, Duchenne - physiopathology Necrosis - genetics Necrosis - pathology Necrosis - physiopathology Neurology Regeneration - physiology Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of Duchenne muscular dystrophy |
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