Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low?
The purpose of this study was to evaluate whether a second cycle of contrast-enhanced voiding urosonography (VUS) with no added contrast medium (CM) can increase the detection rate of vesicoureteral reflux (VUR). One hundred twelve consecutive children with a mean age of 2.9 years with 224 kidney-ur...
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| Veröffentlicht in: | European radiology 2006-11, Vol.16 (11), p.2521-2526 |
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| creator | Papadopoulou, Frederica Tsampoulas, Constantine Siomou, Ekaterini Tzovara, Joannie Siamopoulou, Antigoni Efremidis, Stavros C |
| description | The purpose of this study was to evaluate whether a second cycle of contrast-enhanced voiding urosonography (VUS) with no added contrast medium (CM) can increase the detection rate of vesicoureteral reflux (VUR). One hundred twelve consecutive children with a mean age of 2.9 years with 224 kidney-ureter units (KUU) underwent two cycles of contrast-enhanced harmonic VUS. The first cycle of VUS was performed with 3.5-12.5 ml of suspension 300 mg/ml SH U 508 A and was followed immediately by a second cycle with only saline without adding CM. VUR was detected in 57 KUU from 44 children (39%) at the first cycle of VUS. Eight of the remaining 68 non-refluxing children (12%) demonstrated VUR at the second cycle (P=0.045). Most cases of missed reflux at the first cycle were grade II (75%). However, in two KUU from two children missed reflux was grade III. In one child reflux (grade II) was missed on the second cycle. Comparing the second cycle of VUS with the first cycle, concordant findings regarding the presence or absence as well as the grade of reflux were found in 94% of KUU. A second cycle of contrast-enhanced harmonic VUS with no added CM discloses significantly more cases of VUR at no additional cost for the examination. |
| doi_str_mv | 10.1007/s00330-006-0253-y |
| format | Article |
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Can we keep the cost of the examination low?</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Papadopoulou, Frederica ; Tsampoulas, Constantine ; Siomou, Ekaterini ; Tzovara, Joannie ; Siamopoulou, Antigoni ; Efremidis, Stavros C</creator><creatorcontrib>Papadopoulou, Frederica ; Tsampoulas, Constantine ; Siomou, Ekaterini ; Tzovara, Joannie ; Siamopoulou, Antigoni ; Efremidis, Stavros C</creatorcontrib><description>The purpose of this study was to evaluate whether a second cycle of contrast-enhanced voiding urosonography (VUS) with no added contrast medium (CM) can increase the detection rate of vesicoureteral reflux (VUR). One hundred twelve consecutive children with a mean age of 2.9 years with 224 kidney-ureter units (KUU) underwent two cycles of contrast-enhanced harmonic VUS. The first cycle of VUS was performed with 3.5-12.5 ml of suspension 300 mg/ml SH U 508 A and was followed immediately by a second cycle with only saline without adding CM. VUR was detected in 57 KUU from 44 children (39%) at the first cycle of VUS. Eight of the remaining 68 non-refluxing children (12%) demonstrated VUR at the second cycle (P=0.045). Most cases of missed reflux at the first cycle were grade II (75%). However, in two KUU from two children missed reflux was grade III. In one child reflux (grade II) was missed on the second cycle. Comparing the second cycle of VUS with the first cycle, concordant findings regarding the presence or absence as well as the grade of reflux were found in 94% of KUU. A second cycle of contrast-enhanced harmonic VUS with no added CM discloses significantly more cases of VUR at no additional cost for the examination.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-006-0253-y</identifier><identifier>PMID: 16639494</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adolescent ; Bladder ; Child ; Child, Preschool ; Children ; Contrast media ; Contrast Media - administration & dosage ; Contrast Media - economics ; Female ; Follow-Up Studies ; Greece ; Humans ; Image Enhancement ; Infant ; Infant, Newborn ; Kappa coefficient ; Kidneys ; Male ; Microbubbles ; Patients ; Polysaccharides - administration & dosage ; Polysaccharides - economics ; Radiation ; Refluxing ; Sensitivity and Specificity ; Severity of Illness Index ; Ultrasonography, Interventional - economics ; Ultrasonography, Interventional - methods ; Ureter ; Urinary tract infections ; Urination ; Urogenital system ; Vesico-Ureteral Reflux - diagnostic imaging ; Vesico-Ureteral Reflux - economics ; Vesico-Ureteral Reflux - physiopathology</subject><ispartof>European radiology, 2006-11, Vol.16 (11), p.2521-2526</ispartof><rights>Springer-Verlag 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-774447bb499b4ccf4df98777bf4d06d34a38a93223e7eabb34c947c09ba98e063</citedby><cites>FETCH-LOGICAL-c327t-774447bb499b4ccf4df98777bf4d06d34a38a93223e7eabb34c947c09ba98e063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16639494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papadopoulou, Frederica</creatorcontrib><creatorcontrib>Tsampoulas, Constantine</creatorcontrib><creatorcontrib>Siomou, Ekaterini</creatorcontrib><creatorcontrib>Tzovara, Joannie</creatorcontrib><creatorcontrib>Siamopoulou, Antigoni</creatorcontrib><creatorcontrib>Efremidis, Stavros C</creatorcontrib><title>Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low?</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>The purpose of this study was to evaluate whether a second cycle of contrast-enhanced voiding urosonography (VUS) with no added contrast medium (CM) can increase the detection rate of vesicoureteral reflux (VUR). One hundred twelve consecutive children with a mean age of 2.9 years with 224 kidney-ureter units (KUU) underwent two cycles of contrast-enhanced harmonic VUS. The first cycle of VUS was performed with 3.5-12.5 ml of suspension 300 mg/ml SH U 508 A and was followed immediately by a second cycle with only saline without adding CM. VUR was detected in 57 KUU from 44 children (39%) at the first cycle of VUS. Eight of the remaining 68 non-refluxing children (12%) demonstrated VUR at the second cycle (P=0.045). Most cases of missed reflux at the first cycle were grade II (75%). However, in two KUU from two children missed reflux was grade III. In one child reflux (grade II) was missed on the second cycle. Comparing the second cycle of VUS with the first cycle, concordant findings regarding the presence or absence as well as the grade of reflux were found in 94% of KUU. A second cycle of contrast-enhanced harmonic VUS with no added CM discloses significantly more cases of VUR at no additional cost for the examination.</description><subject>Adolescent</subject><subject>Bladder</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Contrast media</subject><subject>Contrast Media - administration & dosage</subject><subject>Contrast Media - economics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Greece</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Kappa coefficient</subject><subject>Kidneys</subject><subject>Male</subject><subject>Microbubbles</subject><subject>Patients</subject><subject>Polysaccharides - administration & dosage</subject><subject>Polysaccharides - economics</subject><subject>Radiation</subject><subject>Refluxing</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Ultrasonography, Interventional - economics</subject><subject>Ultrasonography, Interventional - methods</subject><subject>Ureter</subject><subject>Urinary tract infections</subject><subject>Urination</subject><subject>Urogenital system</subject><subject>Vesico-Ureteral Reflux - diagnostic imaging</subject><subject>Vesico-Ureteral Reflux - economics</subject><subject>Vesico-Ureteral Reflux - physiopathology</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU9r3DAQxUVpaDZJP0AvRVDoTcnImlrWqZQlTQKBXJqzkGV511tb2kp2El_zyav9A4GcRjC_9xi9R8gXDpccQF4lACGAAZQMih-CzR_IgqMoGIcKP5IFKFExqRSekrOUNgCgOMpP5JSXpVCocEFel7PtO0tt8GM0aWTOr423rqFrE4fg8-opdE3nV3SKIQUfVtFs1zNtQ6Tj2lH3ZPrJjF3wNLQ0urafXi7p0nj67Ohf57Z7yoY07vZ7xYsZOn-Q9OH55wU5aU2f3OfjPCePv6__LG_Z_cPN3fLXPbOikCOTEhFlXaNSNVrbYtOqSkpZ5xeUjUAjKqNEUQgnnalrgVahtKBqoyoHpTgn3w--2xj-TS6NeuiSdX1vvAtT0qXKQeIe_PYO3IQp-nybFrwoK8zZq0zxA2VzLil_XG9jN5g4aw56V48-1KOzq97Vo-es-Xp0nurBNW-KYx_iP3jyjLw</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Papadopoulou, Frederica</creator><creator>Tsampoulas, Constantine</creator><creator>Siomou, Ekaterini</creator><creator>Tzovara, Joannie</creator><creator>Siamopoulou, Antigoni</creator><creator>Efremidis, Stavros C</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low?</title><author>Papadopoulou, Frederica ; Tsampoulas, Constantine ; Siomou, Ekaterini ; Tzovara, Joannie ; Siamopoulou, Antigoni ; Efremidis, Stavros C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-774447bb499b4ccf4df98777bf4d06d34a38a93223e7eabb34c947c09ba98e063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Bladder</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Contrast media</topic><topic>Contrast Media - administration & dosage</topic><topic>Contrast Media - economics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Greece</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Kappa coefficient</topic><topic>Kidneys</topic><topic>Male</topic><topic>Microbubbles</topic><topic>Patients</topic><topic>Polysaccharides - administration & dosage</topic><topic>Polysaccharides - economics</topic><topic>Radiation</topic><topic>Refluxing</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Ultrasonography, Interventional - economics</topic><topic>Ultrasonography, Interventional - methods</topic><topic>Ureter</topic><topic>Urinary tract infections</topic><topic>Urination</topic><topic>Urogenital system</topic><topic>Vesico-Ureteral Reflux - diagnostic imaging</topic><topic>Vesico-Ureteral Reflux - economics</topic><topic>Vesico-Ureteral Reflux - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papadopoulou, Frederica</creatorcontrib><creatorcontrib>Tsampoulas, Constantine</creatorcontrib><creatorcontrib>Siomou, Ekaterini</creatorcontrib><creatorcontrib>Tzovara, Joannie</creatorcontrib><creatorcontrib>Siamopoulou, Antigoni</creatorcontrib><creatorcontrib>Efremidis, Stavros C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papadopoulou, Frederica</au><au>Tsampoulas, Constantine</au><au>Siomou, Ekaterini</au><au>Tzovara, Joannie</au><au>Siamopoulou, Antigoni</au><au>Efremidis, Stavros C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low?</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2006-11</date><risdate>2006</risdate><volume>16</volume><issue>11</issue><spage>2521</spage><epage>2526</epage><pages>2521-2526</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>The purpose of this study was to evaluate whether a second cycle of contrast-enhanced voiding urosonography (VUS) with no added contrast medium (CM) can increase the detection rate of vesicoureteral reflux (VUR). One hundred twelve consecutive children with a mean age of 2.9 years with 224 kidney-ureter units (KUU) underwent two cycles of contrast-enhanced harmonic VUS. The first cycle of VUS was performed with 3.5-12.5 ml of suspension 300 mg/ml SH U 508 A and was followed immediately by a second cycle with only saline without adding CM. VUR was detected in 57 KUU from 44 children (39%) at the first cycle of VUS. Eight of the remaining 68 non-refluxing children (12%) demonstrated VUR at the second cycle (P=0.045). Most cases of missed reflux at the first cycle were grade II (75%). However, in two KUU from two children missed reflux was grade III. In one child reflux (grade II) was missed on the second cycle. Comparing the second cycle of VUS with the first cycle, concordant findings regarding the presence or absence as well as the grade of reflux were found in 94% of KUU. A second cycle of contrast-enhanced harmonic VUS with no added CM discloses significantly more cases of VUR at no additional cost for the examination.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>16639494</pmid><doi>10.1007/s00330-006-0253-y</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Bladder Child Child, Preschool Children Contrast media Contrast Media - administration & dosage Contrast Media - economics Female Follow-Up Studies Greece Humans Image Enhancement Infant Infant, Newborn Kappa coefficient Kidneys Male Microbubbles Patients Polysaccharides - administration & dosage Polysaccharides - economics Radiation Refluxing Sensitivity and Specificity Severity of Illness Index Ultrasonography, Interventional - economics Ultrasonography, Interventional - methods Ureter Urinary tract infections Urination Urogenital system Vesico-Ureteral Reflux - diagnostic imaging Vesico-Ureteral Reflux - economics Vesico-Ureteral Reflux - physiopathology |
| title | Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low? |
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