Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats
The present study was designed to examine the hypoglycaemic and hypolipidemic activity of Inula viscsa aqueous extract on normal and diabetic rats. In normal rats, a significant reduction in blood glucose levels 2 h was observed after a single oral administration ( p < 0.001). Repeated daily oral...
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| Veröffentlicht in: | Journal of ethnopharmacology 2006-11, Vol.108 (2), p.223-227 |
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| creator | Zeggwagh, N.-A. Ouahidi, M.-L. Lemhadri, A. Eddouks, M. |
| description | The present study was designed to examine the hypoglycaemic and hypolipidemic activity of
Inula viscsa aqueous extract on normal and diabetic rats. In normal rats, a significant reduction in blood glucose levels 2
h was observed after a single oral administration (
p
<
0.001). Repeated daily oral administration significantly reduced blood glucose levels after 4 days of treatment (
p
<
0.01). In diabetic rats, a significant reduction in blood glucose levels was observed 1
h after a single oral administration (
p
<
0.001). Repeated oral administration reduced blood glucose levels at the 4th day (
p
<
0.001). No change in total plasma cholesterol and triglyceride levels was observed after both a single and repeated oral administration in both normal and diabetic rats. In addition, plasma insulin levels and body weight remained unchanged after 15 days of repeated oral administration in normal and diabetic rats.
We conclude that
Inula viscosa possess a hypoglycaemic but not hypolipidemic activity in normal and diabetic rats. The observed hypoglycaemic activity seems to be independent of insulin secretion. |
| doi_str_mv | 10.1016/j.jep.2006.05.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69005875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874106002546</els_id><sourcerecordid>69005875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-25cd95bc6c18ec371b9131aca452f773828743e63cabf3e361d28b266a07a9fb3</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhS1ERYfCD2AD3pRdgh-J7RErVBWoNBKL0rV140fxKImDnVTMv68zM1J3rCxdfef43HMR-kBJTQkVX_b13k01I0TUpK0JaV-hDVWSVbKV_DXaEC5VpWRDL9HbnPeEEEkb8gZdUiGVlKzZoOl-XuwBR4__HKb42B8MuCEYDKM9TvowBXucOO-dmfOK3o1LD_gpZBMz4F2N4e_i4pKx-zcnMDMOIx5jGqA_-tgAnZuLRYI5v0MXHvrs3p_fK_Tw_fb3zc9q9-vH3c23XWUaSeeKtcZu284IQ5UzXNJuSzkFA03LvJRcsbIXd4Ib6Dx3XFDLVMeEACJh6zt-hT6ffKcUS7o866HkdX0P4xpVi23pS8m2gPQEmhRzTs7rKYUB0kFTotea9V6XmvVasyatLrKi-Xg2X7rB2RfFudcCXJ8ByAZ6n2A0Ib9wqiGUKFG4TyfOQ9TwmArzcM8I5eVUXDRi_erriXClrKfgks4muNE4G1K5h7Yx_CfoM81epJc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69005875</pqid></control><display><type>article</type><title>Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Zeggwagh, N.-A. ; Ouahidi, M.-L. ; Lemhadri, A. ; Eddouks, M.</creator><creatorcontrib>Zeggwagh, N.-A. ; Ouahidi, M.-L. ; Lemhadri, A. ; Eddouks, M.</creatorcontrib><description>The present study was designed to examine the hypoglycaemic and hypolipidemic activity of
Inula viscsa aqueous extract on normal and diabetic rats. In normal rats, a significant reduction in blood glucose levels 2
h was observed after a single oral administration (
p
<
0.001). Repeated daily oral administration significantly reduced blood glucose levels after 4 days of treatment (
p
<
0.01). In diabetic rats, a significant reduction in blood glucose levels was observed 1
h after a single oral administration (
p
<
0.001). Repeated oral administration reduced blood glucose levels at the 4th day (
p
<
0.001). No change in total plasma cholesterol and triglyceride levels was observed after both a single and repeated oral administration in both normal and diabetic rats. In addition, plasma insulin levels and body weight remained unchanged after 15 days of repeated oral administration in normal and diabetic rats.
We conclude that
Inula viscosa possess a hypoglycaemic but not hypolipidemic activity in normal and diabetic rats. The observed hypoglycaemic activity seems to be independent of insulin secretion.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2006.05.005</identifier><identifier>PMID: 16787724</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Administration, Oral ; Animals ; Aqueous extract ; Biological and medical sciences ; blood glucose ; Blood Glucose - metabolism ; blood lipids ; chemical constituents of plants ; cholesterol ; Cholesterol - blood ; diabetes ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Dittrichia viscosa ; Drug Administration Schedule ; General pharmacology ; glucose tolerance ; Hypoglycaemic activity ; hypoglycemic agents ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - therapeutic use ; hypolipidemia ; insulin ; Insulin - blood ; Inula - chemistry ; Inula viscosa ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - therapeutic use ; Plasma insulin levels ; Rats ; Rats, Wistar ; Time Factors ; Treatment Outcome ; Triglycerides - blood ; Water ; Weight Loss - drug effects</subject><ispartof>Journal of ethnopharmacology, 2006-11, Vol.108 (2), p.223-227</ispartof><rights>2006</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-25cd95bc6c18ec371b9131aca452f773828743e63cabf3e361d28b266a07a9fb3</citedby><cites>FETCH-LOGICAL-c471t-25cd95bc6c18ec371b9131aca452f773828743e63cabf3e361d28b266a07a9fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874106002546$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18401086$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16787724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeggwagh, N.-A.</creatorcontrib><creatorcontrib>Ouahidi, M.-L.</creatorcontrib><creatorcontrib>Lemhadri, A.</creatorcontrib><creatorcontrib>Eddouks, M.</creatorcontrib><title>Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The present study was designed to examine the hypoglycaemic and hypolipidemic activity of
Inula viscsa aqueous extract on normal and diabetic rats. In normal rats, a significant reduction in blood glucose levels 2
h was observed after a single oral administration (
p
<
0.001). Repeated daily oral administration significantly reduced blood glucose levels after 4 days of treatment (
p
<
0.01). In diabetic rats, a significant reduction in blood glucose levels was observed 1
h after a single oral administration (
p
<
0.001). Repeated oral administration reduced blood glucose levels at the 4th day (
p
<
0.001). No change in total plasma cholesterol and triglyceride levels was observed after both a single and repeated oral administration in both normal and diabetic rats. In addition, plasma insulin levels and body weight remained unchanged after 15 days of repeated oral administration in normal and diabetic rats.
We conclude that
Inula viscosa possess a hypoglycaemic but not hypolipidemic activity in normal and diabetic rats. The observed hypoglycaemic activity seems to be independent of insulin secretion.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Aqueous extract</subject><subject>Biological and medical sciences</subject><subject>blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>blood lipids</subject><subject>chemical constituents of plants</subject><subject>cholesterol</subject><subject>Cholesterol - blood</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Dittrichia viscosa</subject><subject>Drug Administration Schedule</subject><subject>General pharmacology</subject><subject>glucose tolerance</subject><subject>Hypoglycaemic activity</subject><subject>hypoglycemic agents</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>hypolipidemia</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>Inula - chemistry</subject><subject>Inula viscosa</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plasma insulin levels</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Triglycerides - blood</subject><subject>Water</subject><subject>Weight Loss - drug effects</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhS1ERYfCD2AD3pRdgh-J7RErVBWoNBKL0rV140fxKImDnVTMv68zM1J3rCxdfef43HMR-kBJTQkVX_b13k01I0TUpK0JaV-hDVWSVbKV_DXaEC5VpWRDL9HbnPeEEEkb8gZdUiGVlKzZoOl-XuwBR4__HKb42B8MuCEYDKM9TvowBXucOO-dmfOK3o1LD_gpZBMz4F2N4e_i4pKx-zcnMDMOIx5jGqA_-tgAnZuLRYI5v0MXHvrs3p_fK_Tw_fb3zc9q9-vH3c23XWUaSeeKtcZu284IQ5UzXNJuSzkFA03LvJRcsbIXd4Ib6Dx3XFDLVMeEACJh6zt-hT6ffKcUS7o866HkdX0P4xpVi23pS8m2gPQEmhRzTs7rKYUB0kFTotea9V6XmvVasyatLrKi-Xg2X7rB2RfFudcCXJ8ByAZ6n2A0Ib9wqiGUKFG4TyfOQ9TwmArzcM8I5eVUXDRi_erriXClrKfgks4muNE4G1K5h7Yx_CfoM81epJc</recordid><startdate>20061124</startdate><enddate>20061124</enddate><creator>Zeggwagh, N.-A.</creator><creator>Ouahidi, M.-L.</creator><creator>Lemhadri, A.</creator><creator>Eddouks, M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061124</creationdate><title>Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats</title><author>Zeggwagh, N.-A. ; Ouahidi, M.-L. ; Lemhadri, A. ; Eddouks, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-25cd95bc6c18ec371b9131aca452f773828743e63cabf3e361d28b266a07a9fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Aqueous extract</topic><topic>Biological and medical sciences</topic><topic>blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>blood lipids</topic><topic>chemical constituents of plants</topic><topic>cholesterol</topic><topic>Cholesterol - blood</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Dittrichia viscosa</topic><topic>Drug Administration Schedule</topic><topic>General pharmacology</topic><topic>glucose tolerance</topic><topic>Hypoglycaemic activity</topic><topic>hypoglycemic agents</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>hypolipidemia</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>Inula - chemistry</topic><topic>Inula viscosa</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plasma insulin levels</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Triglycerides - blood</topic><topic>Water</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeggwagh, N.-A.</creatorcontrib><creatorcontrib>Ouahidi, M.-L.</creatorcontrib><creatorcontrib>Lemhadri, A.</creatorcontrib><creatorcontrib>Eddouks, M.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeggwagh, N.-A.</au><au>Ouahidi, M.-L.</au><au>Lemhadri, A.</au><au>Eddouks, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2006-11-24</date><risdate>2006</risdate><volume>108</volume><issue>2</issue><spage>223</spage><epage>227</epage><pages>223-227</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The present study was designed to examine the hypoglycaemic and hypolipidemic activity of
Inula viscsa aqueous extract on normal and diabetic rats. In normal rats, a significant reduction in blood glucose levels 2
h was observed after a single oral administration (
p
<
0.001). Repeated daily oral administration significantly reduced blood glucose levels after 4 days of treatment (
p
<
0.01). In diabetic rats, a significant reduction in blood glucose levels was observed 1
h after a single oral administration (
p
<
0.001). Repeated oral administration reduced blood glucose levels at the 4th day (
p
<
0.001). No change in total plasma cholesterol and triglyceride levels was observed after both a single and repeated oral administration in both normal and diabetic rats. In addition, plasma insulin levels and body weight remained unchanged after 15 days of repeated oral administration in normal and diabetic rats.
We conclude that
Inula viscosa possess a hypoglycaemic but not hypolipidemic activity in normal and diabetic rats. The observed hypoglycaemic activity seems to be independent of insulin secretion.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16787724</pmid><doi>10.1016/j.jep.2006.05.005</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2006-11, Vol.108 (2), p.223-227 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69005875 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Oral Animals Aqueous extract Biological and medical sciences blood glucose Blood Glucose - metabolism blood lipids chemical constituents of plants cholesterol Cholesterol - blood diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Dittrichia viscosa Drug Administration Schedule General pharmacology glucose tolerance Hypoglycaemic activity hypoglycemic agents Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use hypolipidemia insulin Insulin - blood Inula - chemistry Inula viscosa Male Medical sciences medicinal plants medicinal properties Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy plant extracts Plant Extracts - administration & dosage Plant Extracts - therapeutic use Plasma insulin levels Rats Rats, Wistar Time Factors Treatment Outcome Triglycerides - blood Water Weight Loss - drug effects |
| title | Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats |
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