Synthesis and Antibacterial Activity of Nitroaryl Thiadiazole-Levofloxacin Hybrids

Novel levofloxacin‐containing hybrids carrying a 5‐(nitroaryl)‐1,3,4‐thiadiazol‐2‐yl group were synthesized and evaluated in vitro against Gram‐positive and Gram‐negative bacteria. Preliminary data indicated that levofloxacin‐nitrofuran and levofloxacin‐nitroimidazole hybrids have a potent activity...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2006-11, Vol.339 (11), p.621-624
Hauptverfasser:	Foroumadi, Alireza, Mansouri, Shahla, Emami, Saeed, Mirzaei, Javad, Sorkhi, Maedeh, Saeid-Adeli, Nosratollah, Shafiee, Abbas
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4‐Thiadiazole 4-Thiadiazole Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Levofloxacin Medical sciences Microbial Sensitivity Tests Ofloxacin - analogs & derivatives Ofloxacin - chemical synthesis Ofloxacin - pharmacology Pharmacology. Drug treatments Quinolones Structure-Activity Relationship Thiadiazoles - chemical synthesis Thiadiazoles - pharmacology
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