Encapsulation of dexamethasone into biodegradable polymeric nanoparticles

The present paper concerns both the optimization of dexamethasone (DXM) entrapment and its release from biodegradable poly( d, l-lactide- co-glycolide) (PLGA) nanoparticles prepared by the solvent evaporation process. Since the addition of DXM induced the formation of drug crystals beside the nanopa...

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Veröffentlicht in:	International journal of pharmaceutics 2007-03, Vol.331 (2), p.153-159
Hauptverfasser:	Gómez-Gaete, Carolina, Tsapis, Nicolas, Besnard, Madeleine, Bochot, Amélie, Fattal, Elias
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine Biocompatible Materials - chemistry Biocompatible Materials - therapeutic use Biological and medical sciences Calorimetry, Differential Scanning Crystalline drug Dexamethasone Dexamethasone - administration & dosage Drug Carriers - chemistry General pharmacology Lactic Acid Medical sciences Nanocapsules - chemistry Nanocapsules - therapeutic use Nanoparticles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA Polyglycolic Acid Polymers - chemistry Polymers - therapeutic use Solvents X-Ray Diffraction
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