Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration

Nucleic acid based therapeutics are currently being studied for their application in cancer therapy. In this study, the effect of different cationic delivery systems on the circulation kinetics, tumor localization, and tissue distribution of short interfering RNA (siRNA) and plasmid DNA (pDNA) was e...

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Veröffentlicht in:	International journal of pharmaceutics 2007-03, Vol.331 (2), p.167-175
Hauptverfasser:	de Wolf, Holger K., Snel, Cor J., Verbaan, Ferry J., Schiffelers, Raymond M., Hennink, Wim E., Storm, Gert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cations Circulation kinetics Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics General pharmacology Injections, Intravenous Intravenous administration Male Medical sciences Mice Mice, Inbred Strains Nanoparticles Neoplasms, Experimental - drug therapy Nucleic Acids - administration & dosage Nucleic Acids - pharmacokinetics Organophosphorus Compounds pDNA complexes Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Polyethylene Glycols Polyethyleneimine Polymers - pharmacokinetics Polymers - therapeutic use Polyplexes RNA, Small Interfering - administration & dosage RNA, Small Interfering - pharmacokinetics siRNA complexes Tissue Distribution Tumor localization
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