Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis The Rotterdam Coronary Calcification Study
Findings from laboratory studies strongly suggest a role for apoptosis, the process of programmed cell death, in cardiovascular disease. No population-based study has yet investigated whether serum levels of soluble forms of Fas, a receptor capable of inducing the apoptosis cascade, are associated w...
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| Veröffentlicht in: | Atherosclerosis 2006-12, Vol.189 (2), p.464-469 |
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| creator | VAN DER MEER, Irene M OEI, Hok-Hay S HOFMAN, Albert POLS, Huibert A. P DE JONG, Frank H WITTEMAN, Jacqueline C. M |
| description | Findings from laboratory studies strongly suggest a role for apoptosis, the process of programmed cell death, in cardiovascular disease. No population-based study has yet investigated whether serum levels of soluble forms of Fas, a receptor capable of inducing the apoptosis cascade, are associated with coronary and extracoronary atherosclerosis.
Within the Rotterdam Coronary Calcification Study, a population-based cohort study, we measured coronary calcification using electron-beam computed tomography, abdominal aortic calcification by abdominal X-ray, carotid plaques and common carotid intima-media thickness (IMT) by ultrasonography, and lower extremity atherosclerosis by computation of the ankle-arm index. Levels of sFas and of the inflammatory mediator C-reactive protein (CRP) were measured in 1036 participants.
Levels of sFas were not related to coronary or extracoronary atherosclerosis. CRP showed strong associations with measures of atherosclerosis, including coronary atherosclerosis, which largely remained after adjustment for traditional cardiovascular risk factors.
The results of this study do not support a role for sFas in the identification of subjects with atherosclerosis. |
| doi_str_mv | 10.1016/j.atherosclerosis.2006.01.004 |
| format | Article |
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Within the Rotterdam Coronary Calcification Study, a population-based cohort study, we measured coronary calcification using electron-beam computed tomography, abdominal aortic calcification by abdominal X-ray, carotid plaques and common carotid intima-media thickness (IMT) by ultrasonography, and lower extremity atherosclerosis by computation of the ankle-arm index. Levels of sFas and of the inflammatory mediator C-reactive protein (CRP) were measured in 1036 participants.
Levels of sFas were not related to coronary or extracoronary atherosclerosis. CRP showed strong associations with measures of atherosclerosis, including coronary atherosclerosis, which largely remained after adjustment for traditional cardiovascular risk factors.
The results of this study do not support a role for sFas in the identification of subjects with atherosclerosis.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2006.01.004</identifier><identifier>PMID: 16466728</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Apoptosis - physiology ; Associated diseases and complications ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - blood ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - pathology ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; C-Reactive Protein - metabolism ; Calcinosis - blood ; Calcinosis - diagnostic imaging ; Calcinosis - pathology ; Cardiology. Vascular system ; Cardiovascular system ; Coronary Angiography ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - pathology ; Coronary heart disease ; Coronary Vessels - pathology ; Diabetes. Impaired glucose tolerance ; Disease Progression ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzyme-Linked Immunosorbent Assay ; fas Receptor - blood ; Female ; Follow-Up Studies ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Population Surveillance ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Tomography, X-Ray Computed ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>Atherosclerosis, 2006-12, Vol.189 (2), p.464-469</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18263562$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16466728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DER MEER, Irene M</creatorcontrib><creatorcontrib>OEI, Hok-Hay S</creatorcontrib><creatorcontrib>HOFMAN, Albert</creatorcontrib><creatorcontrib>POLS, Huibert A. P</creatorcontrib><creatorcontrib>DE JONG, Frank H</creatorcontrib><creatorcontrib>WITTEMAN, Jacqueline C. M</creatorcontrib><title>Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis The Rotterdam Coronary Calcification Study</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Findings from laboratory studies strongly suggest a role for apoptosis, the process of programmed cell death, in cardiovascular disease. No population-based study has yet investigated whether serum levels of soluble forms of Fas, a receptor capable of inducing the apoptosis cascade, are associated with coronary and extracoronary atherosclerosis.
Within the Rotterdam Coronary Calcification Study, a population-based cohort study, we measured coronary calcification using electron-beam computed tomography, abdominal aortic calcification by abdominal X-ray, carotid plaques and common carotid intima-media thickness (IMT) by ultrasonography, and lower extremity atherosclerosis by computation of the ankle-arm index. Levels of sFas and of the inflammatory mediator C-reactive protein (CRP) were measured in 1036 participants.
Levels of sFas were not related to coronary or extracoronary atherosclerosis. CRP showed strong associations with measures of atherosclerosis, including coronary atherosclerosis, which largely remained after adjustment for traditional cardiovascular risk factors.
The results of this study do not support a role for sFas in the identification of subjects with atherosclerosis.</description><subject>Apoptosis - physiology</subject><subject>Associated diseases and complications</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - metabolism</subject><subject>Calcinosis - blood</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - pathology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - pathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Disease Progression</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>fas Receptor - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Population Surveillance</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Tomography, X-Ray Computed</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0M1KxDAQB_Agiq6rryC56MnWpE2T5ijFL1gQ_Dgvs-kUI92mJqnoc_jCRl0RLxky_Ehm_oQcc5ZzxuXZcw7xCb0Lpv86bcgLxmTOeM6Y2CIzXiudcVGLbTJjrOCZ5hXbI_shPLMkFK93yR6XQkpV1DPyce_6adUjvYRwSoGusbUQnaeuozC6MX59cUqbzCOYaF-Rjt5FtEPCQ0uN824A__59wbfo4a_zf0z68IT0zsWIvoU1bX5ZA72xnTUQrRvofZza9wOy00Ef8HBT5-Tx8uKhuc4Wt1c3zfkiG4tSx7SYqGusTccUotEtllpLAQy6VWGk1MBBcKmEqlInmUKUXaV0pxRWpdRtOScnP--mlV4mDHG5tsFg38OAbgpLqVOArNIJHm3gtEoBLUdv12n25W-MCRxvAAQDfedhMDb8ubqQZSWL8hNFPIoq</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>VAN DER MEER, Irene M</creator><creator>OEI, Hok-Hay S</creator><creator>HOFMAN, Albert</creator><creator>POLS, Huibert A. P</creator><creator>DE JONG, Frank H</creator><creator>WITTEMAN, Jacqueline C. M</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis The Rotterdam Coronary Calcification Study</title><author>VAN DER MEER, Irene M ; OEI, Hok-Hay S ; HOFMAN, Albert ; POLS, Huibert A. P ; DE JONG, Frank H ; WITTEMAN, Jacqueline C. 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Vascular system</topic><topic>Cardiovascular system</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - pathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Disease Progression</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>fas Receptor - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Population Surveillance</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Tomography, X-Ray Computed</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DER MEER, Irene M</creatorcontrib><creatorcontrib>OEI, Hok-Hay S</creatorcontrib><creatorcontrib>HOFMAN, Albert</creatorcontrib><creatorcontrib>POLS, Huibert A. P</creatorcontrib><creatorcontrib>DE JONG, Frank H</creatorcontrib><creatorcontrib>WITTEMAN, Jacqueline C. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis The Rotterdam Coronary Calcification Study</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>189</volume><issue>2</issue><spage>464</spage><epage>469</epage><pages>464-469</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Findings from laboratory studies strongly suggest a role for apoptosis, the process of programmed cell death, in cardiovascular disease. No population-based study has yet investigated whether serum levels of soluble forms of Fas, a receptor capable of inducing the apoptosis cascade, are associated with coronary and extracoronary atherosclerosis.
Within the Rotterdam Coronary Calcification Study, a population-based cohort study, we measured coronary calcification using electron-beam computed tomography, abdominal aortic calcification by abdominal X-ray, carotid plaques and common carotid intima-media thickness (IMT) by ultrasonography, and lower extremity atherosclerosis by computation of the ankle-arm index. Levels of sFas and of the inflammatory mediator C-reactive protein (CRP) were measured in 1036 participants.
Levels of sFas were not related to coronary or extracoronary atherosclerosis. CRP showed strong associations with measures of atherosclerosis, including coronary atherosclerosis, which largely remained after adjustment for traditional cardiovascular risk factors.
The results of this study do not support a role for sFas in the identification of subjects with atherosclerosis.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>16466728</pmid><doi>10.1016/j.atherosclerosis.2006.01.004</doi><tpages>6</tpages></addata></record> |
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| subjects | Apoptosis - physiology Associated diseases and complications Atherosclerosis (general aspects, experimental research) Atherosclerosis - blood Atherosclerosis - diagnostic imaging Atherosclerosis - pathology Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels C-Reactive Protein - metabolism Calcinosis - blood Calcinosis - diagnostic imaging Calcinosis - pathology Cardiology. Vascular system Cardiovascular system Coronary Angiography Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - pathology Coronary heart disease Coronary Vessels - pathology Diabetes. Impaired glucose tolerance Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme-Linked Immunosorbent Assay fas Receptor - blood Female Follow-Up Studies Heart Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Population Surveillance Prognosis Retrospective Studies Severity of Illness Index Tomography, X-Ray Computed Vasodilator agents. Cerebral vasodilators |
| title | Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis The Rotterdam Coronary Calcification Study |
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