Correlation of interferon-γ production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis
The contribution of interferon-gamma (IFN-gamma) to immunity from amebiasis was assessed in a three-year prospective study of children 2-5 years of age in an urban slum of Dhaka, Bangladesh. IFN-gamma produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2007-02, Vol.76 (2), p.340-344 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | HAQUE, Rashidul MONDAL, Dinesh JIANFEN SHU ROY, Shantanu KABIR, Mamun DAVIS, Andrea N DUGGAL, Priya PETRI, William A |
| description | The contribution of interferon-gamma (IFN-gamma) to immunity from amebiasis was assessed in a three-year prospective study of children 2-5 years of age in an urban slum of Dhaka, Bangladesh. IFN-gamma produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured upon enrollment. Thirty-one of the 209 enrolled children had Entamoeba histolytica-associated diarrhea. Children who produced higher than the median level of IFN-gamma (median = 580 pg/mL) had longer survival without E. histolytica diarrhea/dysentery (log rank test P = 0.03) and a reduction in the risk of E. histolytica diarrhea/dysentery by more than half (Cox proportional hazard regression = 0.45, P = 0.04). When adjusted for stunting, the association between IFN-gamma and the time to the first episode of E. histolytica-associated diarrhea remained marginally significant (Cox proportional hazard regression = 0.49, P = 0.07). We conclude that production of IFN-gamma is linked to nutritional status and predicts future susceptibility to symptomatic amebiasis. |
| doi_str_mv | 10.4269/ajtmh.2007.76.340 |
| format | Article |
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IFN-gamma produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured upon enrollment. Thirty-one of the 209 enrolled children had Entamoeba histolytica-associated diarrhea. Children who produced higher than the median level of IFN-gamma (median = 580 pg/mL) had longer survival without E. histolytica diarrhea/dysentery (log rank test P = 0.03) and a reduction in the risk of E. histolytica diarrhea/dysentery by more than half (Cox proportional hazard regression = 0.45, P = 0.04). When adjusted for stunting, the association between IFN-gamma and the time to the first episode of E. histolytica-associated diarrhea remained marginally significant (Cox proportional hazard regression = 0.49, P = 0.07). We conclude that production of IFN-gamma is linked to nutritional status and predicts future susceptibility to symptomatic amebiasis.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2007.76.340</identifier><identifier>PMID: 17297046</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: Allen Press</publisher><subject>Amibiasis ; Animals ; Anthropometry ; Bangladesh ; Biological and medical sciences ; Child, Preschool ; Cohort Studies ; Diarrhea - blood ; Diarrhea - immunology ; Diarrhea - parasitology ; Entamoeba ; Entamoeba histolytica - immunology ; Entamoebiasis - blood ; Entamoebiasis - immunology ; Entamoebiasis - parasitology ; Enzyme-Linked Immunosorbent Assay ; Feces - parasitology ; Female ; Human protozoal diseases ; Humans ; Infectious diseases ; Interferon-gamma - biosynthesis ; Interferon-gamma - blood ; Interferon-gamma - immunology ; Interleukin-5 - biosynthesis ; Interleukin-5 - immunology ; Kaplan-Meier Estimate ; Leukocytes, Mononuclear - immunology ; Male ; Malnutrition - blood ; Malnutrition - immunology ; Medical sciences ; Metabolic diseases ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Parasitic diseases ; Poverty Areas ; Proportional Hazards Models ; Prospective Studies ; Protozoal diseases ; Urban Population</subject><ispartof>The American journal of tropical medicine and hygiene, 2007-02, Vol.76 (2), p.340-344</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18533863$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17297046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAQUE, Rashidul</creatorcontrib><creatorcontrib>MONDAL, Dinesh</creatorcontrib><creatorcontrib>JIANFEN SHU</creatorcontrib><creatorcontrib>ROY, Shantanu</creatorcontrib><creatorcontrib>KABIR, Mamun</creatorcontrib><creatorcontrib>DAVIS, Andrea N</creatorcontrib><creatorcontrib>DUGGAL, Priya</creatorcontrib><creatorcontrib>PETRI, William A</creatorcontrib><title>Correlation of interferon-γ production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>The contribution of interferon-gamma (IFN-gamma) to immunity from amebiasis was assessed in a three-year prospective study of children 2-5 years of age in an urban slum of Dhaka, Bangladesh. IFN-gamma produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured upon enrollment. Thirty-one of the 209 enrolled children had Entamoeba histolytica-associated diarrhea. Children who produced higher than the median level of IFN-gamma (median = 580 pg/mL) had longer survival without E. histolytica diarrhea/dysentery (log rank test P = 0.03) and a reduction in the risk of E. histolytica diarrhea/dysentery by more than half (Cox proportional hazard regression = 0.45, P = 0.04). When adjusted for stunting, the association between IFN-gamma and the time to the first episode of E. histolytica-associated diarrhea remained marginally significant (Cox proportional hazard regression = 0.49, P = 0.07). We conclude that production of IFN-gamma is linked to nutritional status and predicts future susceptibility to symptomatic amebiasis.</description><subject>Amibiasis</subject><subject>Animals</subject><subject>Anthropometry</subject><subject>Bangladesh</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Diarrhea - blood</subject><subject>Diarrhea - immunology</subject><subject>Diarrhea - parasitology</subject><subject>Entamoeba</subject><subject>Entamoeba histolytica - immunology</subject><subject>Entamoebiasis - blood</subject><subject>Entamoebiasis - immunology</subject><subject>Entamoebiasis - parasitology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Feces - parasitology</subject><subject>Female</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - blood</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin-5 - biosynthesis</subject><subject>Interleukin-5 - immunology</subject><subject>Kaplan-Meier Estimate</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Male</subject><subject>Malnutrition - blood</subject><subject>Malnutrition - immunology</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Parasitic diseases</subject><subject>Poverty Areas</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Protozoal diseases</subject><subject>Urban Population</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-OFCEQh4nRuOPqA3gxXPTWI9Uw0BzNxH_JJl70TGig02xoaIGOmUfweXwPn0lmdpI9eqpDffVLVX0IvQayZz2X7_V9XeZ9T4jYC76njDxBO2CCd8DZ4SnaEUL6TnIqbtCLUu4JgaEHeI5uQPRSEMZ36Pcx5eyCrj5FnCbsY3V5cjnF7u8fvOZkN3PpjSe8uuzX2WUd8BhSsnhJMcXNBKczNi6Egn_5OmMz-2DnC6BD3Gr2lwQdLS5bMW6tfvTB1xOuCevFjV4XX16iZ5MOxb261lv049PH78cv3d23z1-PH-46Q6Gv7RzQgowMpgncOEojLLcDDMIJK80AjAOIQbID0QLsICmjnFs3UKKBUz7RW_TuIbcd93NzparFl_P2Orq0FcVl-1r73H_BnhxaupQNhAfQ5FRKdpNas190Pikg6ixKXUSpsygluGqi2syba_g2Ls4-TlzNNODtFdDF6DBlHY0vj9xwoHTglP4Dx1ugcQ</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>HAQUE, Rashidul</creator><creator>MONDAL, Dinesh</creator><creator>JIANFEN SHU</creator><creator>ROY, Shantanu</creator><creator>KABIR, Mamun</creator><creator>DAVIS, Andrea N</creator><creator>DUGGAL, Priya</creator><creator>PETRI, William A</creator><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Correlation of interferon-γ production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis</title><author>HAQUE, Rashidul ; MONDAL, Dinesh ; JIANFEN SHU ; ROY, Shantanu ; KABIR, Mamun ; DAVIS, Andrea N ; DUGGAL, Priya ; PETRI, William A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-961a70b41ff1ebb9c7d6d8187e7d9c814611789450a71d8934366de830a1636f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Amibiasis</topic><topic>Animals</topic><topic>Anthropometry</topic><topic>Bangladesh</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Diarrhea - blood</topic><topic>Diarrhea - immunology</topic><topic>Diarrhea - parasitology</topic><topic>Entamoeba</topic><topic>Entamoeba histolytica - immunology</topic><topic>Entamoebiasis - blood</topic><topic>Entamoebiasis - immunology</topic><topic>Entamoebiasis - parasitology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Feces - parasitology</topic><topic>Female</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - blood</topic><topic>Interferon-gamma - immunology</topic><topic>Interleukin-5 - biosynthesis</topic><topic>Interleukin-5 - immunology</topic><topic>Kaplan-Meier Estimate</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Male</topic><topic>Malnutrition - blood</topic><topic>Malnutrition - immunology</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Parasitic diseases</topic><topic>Poverty Areas</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Protozoal diseases</topic><topic>Urban Population</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAQUE, Rashidul</creatorcontrib><creatorcontrib>MONDAL, Dinesh</creatorcontrib><creatorcontrib>JIANFEN SHU</creatorcontrib><creatorcontrib>ROY, Shantanu</creatorcontrib><creatorcontrib>KABIR, Mamun</creatorcontrib><creatorcontrib>DAVIS, Andrea N</creatorcontrib><creatorcontrib>DUGGAL, Priya</creatorcontrib><creatorcontrib>PETRI, William A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAQUE, Rashidul</au><au>MONDAL, Dinesh</au><au>JIANFEN SHU</au><au>ROY, Shantanu</au><au>KABIR, Mamun</au><au>DAVIS, Andrea N</au><au>DUGGAL, Priya</au><au>PETRI, William A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of interferon-γ production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>76</volume><issue>2</issue><spage>340</spage><epage>344</epage><pages>340-344</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>The contribution of interferon-gamma (IFN-gamma) to immunity from amebiasis was assessed in a three-year prospective study of children 2-5 years of age in an urban slum of Dhaka, Bangladesh. IFN-gamma produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured upon enrollment. Thirty-one of the 209 enrolled children had Entamoeba histolytica-associated diarrhea. Children who produced higher than the median level of IFN-gamma (median = 580 pg/mL) had longer survival without E. histolytica diarrhea/dysentery (log rank test P = 0.03) and a reduction in the risk of E. histolytica diarrhea/dysentery by more than half (Cox proportional hazard regression = 0.45, P = 0.04). When adjusted for stunting, the association between IFN-gamma and the time to the first episode of E. histolytica-associated diarrhea remained marginally significant (Cox proportional hazard regression = 0.49, P = 0.07). We conclude that production of IFN-gamma is linked to nutritional status and predicts future susceptibility to symptomatic amebiasis.</abstract><cop>Lawrence, KS</cop><pub>Allen Press</pub><pmid>17297046</pmid><doi>10.4269/ajtmh.2007.76.340</doi><tpages>5</tpages></addata></record> |
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| subjects | Amibiasis Animals Anthropometry Bangladesh Biological and medical sciences Child, Preschool Cohort Studies Diarrhea - blood Diarrhea - immunology Diarrhea - parasitology Entamoeba Entamoeba histolytica - immunology Entamoebiasis - blood Entamoebiasis - immunology Entamoebiasis - parasitology Enzyme-Linked Immunosorbent Assay Feces - parasitology Female Human protozoal diseases Humans Infectious diseases Interferon-gamma - biosynthesis Interferon-gamma - blood Interferon-gamma - immunology Interleukin-5 - biosynthesis Interleukin-5 - immunology Kaplan-Meier Estimate Leukocytes, Mononuclear - immunology Male Malnutrition - blood Malnutrition - immunology Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Parasitic diseases Poverty Areas Proportional Hazards Models Prospective Studies Protozoal diseases Urban Population |
| title | Correlation of interferon-γ production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis |
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