Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers
In a previous study, we have shown that cidofovir (CDV) and azidothymidine-triphosphate (AZT-TP) were poorly encapsulated in poly( iso-butylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and hydrophilic molecules through the thin polymer wal...
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| Veröffentlicht in: | International journal of pharmaceutics 2007-03, Vol.331 (2), p.148-152 |
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| container_title | International journal of pharmaceutics |
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| creator | Hillaireau, H. Le Doan, T. Chacun, H. Janin, J. Couvreur, P. |
| description | In a previous study, we have shown that cidofovir (CDV) and azidothymidine-triphosphate (AZT-TP) were poorly encapsulated in poly(
iso-butylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and hydrophilic molecules through the thin polymer wall of the nanocapsules. In the present study, we have selected various water-soluble polymers as increasing Mw adjuvants and investigated their influence on the entrapment of mononucleotides (CDV, AZT-TP) as well as of oligonucleotides (ODN) into these PIBCA aqueous-core nanocapsules. We show here that the presence of cationic polymers (i.e. poly(ethyleneimine) (PEI) or chitosan) in the nanocapsule aqueous compartment allowed successful encapsulation of AZT-TP and ODN. |
| doi_str_mv | 10.1016/j.ijpharm.2006.10.031 |
| format | Article |
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iso-butylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and hydrophilic molecules through the thin polymer wall of the nanocapsules. In the present study, we have selected various water-soluble polymers as increasing Mw adjuvants and investigated their influence on the entrapment of mononucleotides (CDV, AZT-TP) as well as of oligonucleotides (ODN) into these PIBCA aqueous-core nanocapsules. We show here that the presence of cationic polymers (i.e. poly(ethyleneimine) (PEI) or chitosan) in the nanocapsule aqueous compartment allowed successful encapsulation of AZT-TP and ODN.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2006.10.031</identifier><identifier>PMID: 17150318</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject><![CDATA[Azidothymidine-triphosphate ; Biological and medical sciences ; Cations ; Chitosan - therapeutic use ; Cidofovir ; Cyanoacrylates - therapeutic use ; Cytosine - administration & dosage ; Cytosine - analogs & derivatives ; Dideoxynucleotides ; Drug Carriers - chemistry ; General pharmacology ; Materials Testing ; Medical sciences ; Nanocapsules ; Nanocapsules - chemistry ; Nanocapsules - therapeutic use ; Nucleotides - administration & dosage ; Oligonucleotides ; Oligonucleotides - administration & dosage ; Organophosphonates - administration & dosage ; Permeability ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Poly(alkylcyanoacrylate) ; Polyethyleneimine - therapeutic use ; Polymers - therapeutic use ; Solubility ; Thymine Nucleotides - administration & dosage ; Water ; Zidovudine - administration & dosage ; Zidovudine - analogs & derivatives]]></subject><ispartof>International journal of pharmaceutics, 2007-03, Vol.331 (2), p.148-152</ispartof><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-791bc52b347a88603bde97a82a7c93bd135a9af942a49a7394eb7a18b28660ce3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517306008994$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18588547$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17150318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hillaireau, H.</creatorcontrib><creatorcontrib>Le Doan, T.</creatorcontrib><creatorcontrib>Chacun, H.</creatorcontrib><creatorcontrib>Janin, J.</creatorcontrib><creatorcontrib>Couvreur, P.</creatorcontrib><title>Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>In a previous study, we have shown that cidofovir (CDV) and azidothymidine-triphosphate (AZT-TP) were poorly encapsulated in poly(
iso-butylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and hydrophilic molecules through the thin polymer wall of the nanocapsules. In the present study, we have selected various water-soluble polymers as increasing Mw adjuvants and investigated their influence on the entrapment of mononucleotides (CDV, AZT-TP) as well as of oligonucleotides (ODN) into these PIBCA aqueous-core nanocapsules. We show here that the presence of cationic polymers (i.e. poly(ethyleneimine) (PEI) or chitosan) in the nanocapsule aqueous compartment allowed successful encapsulation of AZT-TP and ODN.</description><subject>Azidothymidine-triphosphate</subject><subject>Biological and medical sciences</subject><subject>Cations</subject><subject>Chitosan - therapeutic use</subject><subject>Cidofovir</subject><subject>Cyanoacrylates - therapeutic use</subject><subject>Cytosine - administration & dosage</subject><subject>Cytosine - analogs & derivatives</subject><subject>Dideoxynucleotides</subject><subject>Drug Carriers - chemistry</subject><subject>General pharmacology</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Nanocapsules</subject><subject>Nanocapsules - chemistry</subject><subject>Nanocapsules - therapeutic use</subject><subject>Nucleotides - administration & dosage</subject><subject>Oligonucleotides</subject><subject>Oligonucleotides - administration & dosage</subject><subject>Organophosphonates - administration & dosage</subject><subject>Permeability</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Poly(alkylcyanoacrylate)</subject><subject>Polyethyleneimine - therapeutic use</subject><subject>Polymers - therapeutic use</subject><subject>Solubility</subject><subject>Thymine Nucleotides - administration & dosage</subject><subject>Water</subject><subject>Zidovudine - administration & dosage</subject><subject>Zidovudine - analogs & derivatives</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2P1SAUQInROM_Rn6BhozueUNpCV8ZMRmeSSdzomtzSW-WFQoV2zPv3Ul-TWboCLud-HULeCn4UXLQfT0d3mn9Bmo4V522JHbkUz8hBaCWZrFX7nBy4VJo1Qskr8irnEy9gJeRLciWUaAquD-R8GyzMefWwuBhoHOkUQ2QUwkCjdz8jC6v1GBc3YKYuLJHC7xXjmpmNCWmAEC8F_n3TOWHGYHGr9AjJFZD-gQUTy9GvvUc6R3-eMOXX5MUIPuOb_bwmP77cfr-5Yw_fvt7ffH5gVnZyYaoTvW2qvqwEWrdc9gN25VqBsl15CNlAB2NXV1B3oGRXY69A6L7Sbcstymvy4VJ3TrFMnhczuWzRewjbGqbtOBdFTAGbC2hTzDnhaObkJkhnI7jZnJuT2Z2bzfkWLhJL3ru9wdpPODxl7ZIL8H4HIFvwY4JgXX7idKN1U6vCfbpwWHQ8OkwmW7fJHFxCu5ghuv-M8hejD6Tr</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Hillaireau, H.</creator><creator>Le Doan, T.</creator><creator>Chacun, H.</creator><creator>Janin, J.</creator><creator>Couvreur, P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers</title><author>Hillaireau, H. ; Le Doan, T. ; Chacun, H. ; Janin, J. ; Couvreur, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-791bc52b347a88603bde97a82a7c93bd135a9af942a49a7394eb7a18b28660ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Azidothymidine-triphosphate</topic><topic>Biological and medical sciences</topic><topic>Cations</topic><topic>Chitosan - therapeutic use</topic><topic>Cidofovir</topic><topic>Cyanoacrylates - therapeutic use</topic><topic>Cytosine - administration & dosage</topic><topic>Cytosine - analogs & derivatives</topic><topic>Dideoxynucleotides</topic><topic>Drug Carriers - chemistry</topic><topic>General pharmacology</topic><topic>Materials Testing</topic><topic>Medical sciences</topic><topic>Nanocapsules</topic><topic>Nanocapsules - chemistry</topic><topic>Nanocapsules - therapeutic use</topic><topic>Nucleotides - administration & dosage</topic><topic>Oligonucleotides</topic><topic>Oligonucleotides - administration & dosage</topic><topic>Organophosphonates - administration & dosage</topic><topic>Permeability</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Poly(alkylcyanoacrylate)</topic><topic>Polyethyleneimine - therapeutic use</topic><topic>Polymers - therapeutic use</topic><topic>Solubility</topic><topic>Thymine Nucleotides - administration & dosage</topic><topic>Water</topic><topic>Zidovudine - administration & dosage</topic><topic>Zidovudine - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillaireau, H.</creatorcontrib><creatorcontrib>Le Doan, T.</creatorcontrib><creatorcontrib>Chacun, H.</creatorcontrib><creatorcontrib>Janin, J.</creatorcontrib><creatorcontrib>Couvreur, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillaireau, H.</au><au>Le Doan, T.</au><au>Chacun, H.</au><au>Janin, J.</au><au>Couvreur, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>331</volume><issue>2</issue><spage>148</spage><epage>152</epage><pages>148-152</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>In a previous study, we have shown that cidofovir (CDV) and azidothymidine-triphosphate (AZT-TP) were poorly encapsulated in poly(
iso-butylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and hydrophilic molecules through the thin polymer wall of the nanocapsules. In the present study, we have selected various water-soluble polymers as increasing Mw adjuvants and investigated their influence on the entrapment of mononucleotides (CDV, AZT-TP) as well as of oligonucleotides (ODN) into these PIBCA aqueous-core nanocapsules. We show here that the presence of cationic polymers (i.e. poly(ethyleneimine) (PEI) or chitosan) in the nanocapsule aqueous compartment allowed successful encapsulation of AZT-TP and ODN.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17150318</pmid><doi>10.1016/j.ijpharm.2006.10.031</doi><tpages>5</tpages></addata></record> |
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| subjects | Azidothymidine-triphosphate Biological and medical sciences Cations Chitosan - therapeutic use Cidofovir Cyanoacrylates - therapeutic use Cytosine - administration & dosage Cytosine - analogs & derivatives Dideoxynucleotides Drug Carriers - chemistry General pharmacology Materials Testing Medical sciences Nanocapsules Nanocapsules - chemistry Nanocapsules - therapeutic use Nucleotides - administration & dosage Oligonucleotides Oligonucleotides - administration & dosage Organophosphonates - administration & dosage Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(alkylcyanoacrylate) Polyethyleneimine - therapeutic use Polymers - therapeutic use Solubility Thymine Nucleotides - administration & dosage Water Zidovudine - administration & dosage Zidovudine - analogs & derivatives |
| title | Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers |
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