Familial clustering of multiple sclerosis in a Dutch genetic isolate

Multiple sclerosis (MS) is a complex disease with a substantial, yet poorly identified, genetic influence. We estimated the pattern of familial aggregation of MS in a recent genetically isolated population in the Netherlands. Forty-eight MS patients were identified. Their relationship was evaluated...

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Veröffentlicht in:	Multiple sclerosis 2007-01, Vol.13 (1), p.17-24
Hauptverfasser:	Hoppenbrouwers, I A, Cortes, LM Pardo, Aulchenko, Y S, Sintnicolaas, K, Njajou, O, Snijders, P JLM, Oostra, B A, van Duijn, C M, Hintzen, R Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Biological and medical sciences Cluster Analysis Consanguinity Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics Family Health Female Genetic Predisposition to Disease - epidemiology Histocompatibility Testing HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Immunomodulators Male Medical sciences Middle Aged Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Netherlands - epidemiology Neurology Pedigree Pharmacology. Drug treatments Prevalence Thyroid Diseases - epidemiology Thyroid Diseases - genetics
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