Role of parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure

Chronic renal failure (CRF) is associated with a decrease in drug metabolism secondary to a decrease in liver cytochrome P450 (P450). The predominant theory to explain this decrease is the presence of factors in the blood of uremic patients. This study tested the hypothesis that parathyroid hormone...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2006-11, Vol.17 (11), p.3041-3048
Hauptverfasser:	MICHAUD, Josée, NAUD, Judith, CHOUINARD, Jerome, DESY, Francois, LEBLOND, Francois A, DESBIENS, Karine, BONNARDEAUX, Alain, PICHETTE, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Cytochrome P-450 Enzyme System - physiology Down-Regulation Hepatocytes - metabolism Kidney Failure, Chronic - physiopathology Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Parathyroid Hormone - physiology Rats Rats, Sprague-Dawley Renal failure
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