Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging
In osteomalacia decreased mineralization reduces the stiffness and static strength of bone. We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid‐state 31P magnetic resonance imaging (SS‐MRI). Hypomineralization was measured with a 3D radial imaging technique at 1...
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| Veröffentlicht in: | Magnetic resonance in medicine 2006-11, Vol.56 (5), p.946-952 |
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| creator | Anumula, S. Magland, J. Wehrli, S.L. Zhang, H. Ong, H. Song, H.K. Wehrli, F.W. |
| description | In osteomalacia decreased mineralization reduces the stiffness and static strength of bone. We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid‐state 31P magnetic resonance imaging (SS‐MRI). Hypomineralization was measured with a 3D radial imaging technique at 162 MHz (9.4T) in rabbit cortical bone of hypophosphatemic (HY) and normophosphatemic (NO) animals. The results were compared with those obtained by quantitative micro‐CT (μ‐CT) and 31P solution NMR. 3D images of 277 μm isotropic voxel size were obtained in 1.7 hr with SNR ∼ 9. Mineral content was lower in the HY relative to the NO group (SS‐MRI: 9.48 ± 0.4 vs. 11.15 ± 0.31 phosphorus wet wt %, P < 0.0001; μ‐CT: 1114.6 ± 28.3 vs. 1175.7 ± 23.5 mg mineral/cm3; P = 0.003). T1 was shorter in the HY group (47.2 ± 3.5 vs. 54.1 ± 2.7 s, P = 0.004), which suggests that relaxation occurs via a dipole‐dipole (DD) mechanism involving exchangeable water protons, which are more prevalent in bone from osteomalacic animals. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.21050 |
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We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid‐state 31P magnetic resonance imaging (SS‐MRI). Hypomineralization was measured with a 3D radial imaging technique at 162 MHz (9.4T) in rabbit cortical bone of hypophosphatemic (HY) and normophosphatemic (NO) animals. The results were compared with those obtained by quantitative micro‐CT (μ‐CT) and 31P solution NMR. 3D images of 277 μm isotropic voxel size were obtained in 1.7 hr with SNR ∼ 9. Mineral content was lower in the HY relative to the NO group (SS‐MRI: 9.48 ± 0.4 vs. 11.15 ± 0.31 phosphorus wet wt %, P < 0.0001; μ‐CT: 1114.6 ± 28.3 vs. 1175.7 ± 23.5 mg mineral/cm3; P = 0.003). T1 was shorter in the HY group (47.2 ± 3.5 vs. 54.1 ± 2.7 s, P = 0.004), which suggests that relaxation occurs via a dipole‐dipole (DD) mechanism involving exchangeable water protons, which are more prevalent in bone from osteomalacic animals. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.21050</identifier><identifier>PMID: 17041893</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Anatomy, Cross-Sectional - methods ; Animals ; Biomarkers - analysis ; Bone Density ; Feasibility Studies ; Femur - metabolism ; Femur - pathology ; Humans ; Imaging, Three-Dimensional - methods ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy - methods ; Osteomalacia - diagnosis ; Osteomalacia - metabolism ; Phosphorus - analysis ; Phosphorus Radioisotopes ; Rabbits ; Reproducibility of Results ; Sensitivity and Specificity ; Tibia - metabolism ; Tibia - pathology</subject><ispartof>Magnetic resonance in medicine, 2006-11, Vol.56 (5), p.946-952</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>(c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4270-b0e8c194ae7e74238ccf873f786c65d407effdf8ae0a159f500b523d145f03b93</citedby><cites>FETCH-LOGICAL-c4270-b0e8c194ae7e74238ccf873f786c65d407effdf8ae0a159f500b523d145f03b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.21050$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.21050$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17041893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anumula, S.</creatorcontrib><creatorcontrib>Magland, J.</creatorcontrib><creatorcontrib>Wehrli, S.L.</creatorcontrib><creatorcontrib>Zhang, H.</creatorcontrib><creatorcontrib>Ong, H.</creatorcontrib><creatorcontrib>Song, H.K.</creatorcontrib><creatorcontrib>Wehrli, F.W.</creatorcontrib><title>Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>In osteomalacia decreased mineralization reduces the stiffness and static strength of bone. We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid‐state 31P magnetic resonance imaging (SS‐MRI). Hypomineralization was measured with a 3D radial imaging technique at 162 MHz (9.4T) in rabbit cortical bone of hypophosphatemic (HY) and normophosphatemic (NO) animals. The results were compared with those obtained by quantitative micro‐CT (μ‐CT) and 31P solution NMR. 3D images of 277 μm isotropic voxel size were obtained in 1.7 hr with SNR ∼ 9. Mineral content was lower in the HY relative to the NO group (SS‐MRI: 9.48 ± 0.4 vs. 11.15 ± 0.31 phosphorus wet wt %, P < 0.0001; μ‐CT: 1114.6 ± 28.3 vs. 1175.7 ± 23.5 mg mineral/cm3; P = 0.003). T1 was shorter in the HY group (47.2 ± 3.5 vs. 54.1 ± 2.7 s, P = 0.004), which suggests that relaxation occurs via a dipole‐dipole (DD) mechanism involving exchangeable water protons, which are more prevalent in bone from osteomalacic animals. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Anatomy, Cross-Sectional - methods</subject><subject>Animals</subject><subject>Biomarkers - analysis</subject><subject>Bone Density</subject><subject>Feasibility Studies</subject><subject>Femur - metabolism</subject><subject>Femur - pathology</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Osteomalacia - diagnosis</subject><subject>Osteomalacia - metabolism</subject><subject>Phosphorus - analysis</subject><subject>Phosphorus Radioisotopes</subject><subject>Rabbits</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tibia - metabolism</subject><subject>Tibia - pathology</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-PFCEQxYnRuLOrB7-A4WTioXeLfw0czayuJjOaTDQeCU3DinY3I3RH59sv64x6Mh4qpOD3Xop6CD0jcEkA6NWYx0tKQMADtCKC0oYKzR-iFUgODSOan6HzUr4CgNaSP0ZnRAInSrMViltvy5L96KcZp4D3X1KplZeCXZrm-9s44Snl0Q7YTj1OZfapNtZFh7PtujjjLk0edwdc0hD7psx29phd19c-VlUc7W2cbp-gR8EOxT89nRfo05vXH9dvm82Hm3frV5vGcSqh6cArV0e2XnrJKVPOBSVZkKp1reg5SB9CH5T1YInQQQB0grKecBGAdZpdoBdH331O3xdfZjPG4vww2MmnpZhWaa0VtP8FKSghRSsq-PIIupxKyT6Yfa6fygdDwNwHYGoA5lcAlX1-Ml260fd_ydPGK3B1BH7EwR_-7WS2u-1vy-aoiHX1P_8obP5mWsmkMJ_f35g1V7vdRrZmze4Aaf2fRg</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Anumula, S.</creator><creator>Magland, J.</creator><creator>Wehrli, S.L.</creator><creator>Zhang, H.</creator><creator>Ong, H.</creator><creator>Song, H.K.</creator><creator>Wehrli, F.W.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging</title><author>Anumula, S. ; Magland, J. ; Wehrli, S.L. ; Zhang, H. ; Ong, H. ; Song, H.K. ; Wehrli, F.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4270-b0e8c194ae7e74238ccf873f786c65d407effdf8ae0a159f500b523d145f03b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anatomy, Cross-Sectional - methods</topic><topic>Animals</topic><topic>Biomarkers - analysis</topic><topic>Bone Density</topic><topic>Feasibility Studies</topic><topic>Femur - metabolism</topic><topic>Femur - pathology</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Osteomalacia - diagnosis</topic><topic>Osteomalacia - metabolism</topic><topic>Phosphorus - analysis</topic><topic>Phosphorus Radioisotopes</topic><topic>Rabbits</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Tibia - metabolism</topic><topic>Tibia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anumula, S.</creatorcontrib><creatorcontrib>Magland, J.</creatorcontrib><creatorcontrib>Wehrli, S.L.</creatorcontrib><creatorcontrib>Zhang, H.</creatorcontrib><creatorcontrib>Ong, H.</creatorcontrib><creatorcontrib>Song, H.K.</creatorcontrib><creatorcontrib>Wehrli, F.W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anumula, S.</au><au>Magland, J.</au><au>Wehrli, S.L.</au><au>Zhang, H.</au><au>Ong, H.</au><au>Song, H.K.</au><au>Wehrli, F.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2006-11</date><risdate>2006</risdate><volume>56</volume><issue>5</issue><spage>946</spage><epage>952</epage><pages>946-952</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>In osteomalacia decreased mineralization reduces the stiffness and static strength of bone. We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid‐state 31P magnetic resonance imaging (SS‐MRI). Hypomineralization was measured with a 3D radial imaging technique at 162 MHz (9.4T) in rabbit cortical bone of hypophosphatemic (HY) and normophosphatemic (NO) animals. The results were compared with those obtained by quantitative micro‐CT (μ‐CT) and 31P solution NMR. 3D images of 277 μm isotropic voxel size were obtained in 1.7 hr with SNR ∼ 9. Mineral content was lower in the HY relative to the NO group (SS‐MRI: 9.48 ± 0.4 vs. 11.15 ± 0.31 phosphorus wet wt %, P < 0.0001; μ‐CT: 1114.6 ± 28.3 vs. 1175.7 ± 23.5 mg mineral/cm3; P = 0.003). T1 was shorter in the HY group (47.2 ± 3.5 vs. 54.1 ± 2.7 s, P = 0.004), which suggests that relaxation occurs via a dipole‐dipole (DD) mechanism involving exchangeable water protons, which are more prevalent in bone from osteomalacic animals. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17041893</pmid><doi>10.1002/mrm.21050</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anatomy, Cross-Sectional - methods Animals Biomarkers - analysis Bone Density Feasibility Studies Femur - metabolism Femur - pathology Humans Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Osteomalacia - diagnosis Osteomalacia - metabolism Phosphorus - analysis Phosphorus Radioisotopes Rabbits Reproducibility of Results Sensitivity and Specificity Tibia - metabolism Tibia - pathology |
| title | Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging |
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