Simultaneous quantification of acylcarnitine isomers containing dicarboxylic acylcarnitines in human serum and urine by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry

Tandem mass spectrometry (MS/MS) has become a prominent method for screening newborns for diseases such as organic acidemia and fatty acid oxidation defects, although current methods cannot separate acylcarnitine isomers. Accurate determination of dicarboxylic acylcarnitines such as methylmalonylcar...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2007-01, Vol.21 (5), p.799-806
Hauptverfasser:	Maeda, Yasuhiro, Ito, Tetsuya, Suzuki, Atsuko, Kurono, Yukihisa, Ueta, Akihito, Yokoi, Kyoko, Sumi, Satoshi, Togari, Hajime, Sugiyama, Naruji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Carnitine - analogs & derivatives Carnitine - blood Carnitine - chemistry Carnitine - urine Child, Preschool Female Humans Isomerism Male Metabolism, Inborn Errors - blood Metabolism, Inborn Errors - enzymology Metabolism, Inborn Errors - urine Methylmalonic Acid - blood Methylmalonyl-CoA Mutase - metabolism Spectrometry, Mass, Electrospray Ionization
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