Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling

Clinical evidence suggests that dopamine D(2) receptor partial agonists must have a sufficiently low intrinsic activity to be effective as antipsychotics. Here, we used dopamine D(2) receptor signaling assays to compare the in vitro functional characteristics of the antipsychotic aripiprazole with o...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2007-03, Vol.31 (2), p.348-356
Hauptverfasser:	JORDAN, Shaun, JOHNSON, Janelle L, REGARDIE, Karen, RUOYAN CHEN, KOPRIVICA, Vuk, TADORI, Yoshihiro, KAMBAYASHI, Junichi, KITAGAWA, Hisashi, KIKUCHI, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Arachidonic Acid - metabolism Binding, Competitive Biological and medical sciences Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Corpus Striatum - cytology Cricetinae Cricetulus Cyclic AMP - metabolism Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics Humans Male Medical sciences Neurons - cytology Neuropharmacology Pharmacology. Drug treatments Protein Binding - drug effects Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - physiology Schizophrenia Signal Transduction - drug effects Signal Transduction - physiology Sulfur Isotopes - pharmacokinetics Transfection - methods
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