Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma
Abstract Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine implicated in tumour vasculogenesis. A significant increase in vascularity occurs during the transition from normal oral mucosa (NOM), through dysplasia, to squamous cell carcinoma (SCC). This study investigated the p...
Gespeichert in:
| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2007-03, Vol.36 (3), p.263-266 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 266 |
|---|---|
| container_issue | 3 |
| container_start_page | 263 |
| container_title | International journal of oral and maxillofacial surgery |
| container_volume | 36 |
| creator | Johnstone, S Logan, R.M |
| description | Abstract Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine implicated in tumour vasculogenesis. A significant increase in vascularity occurs during the transition from normal oral mucosa (NOM), through dysplasia, to squamous cell carcinoma (SCC). This study investigated the presence of VEGF in NOM, oral dysplasia and SCC. The correlation between VEGF expression and the grade of dysplasia or differentiation of SCC was also examined. Specimens consisting of NOM, oral dysplastic lesions and oral SCC were stained using standard immunohistochemistry methods to determine VEGF expression. Statistical analysis indicated an up-regulation of VEGF during the transition from NOM, through dysplasia to SCC. There was also a significant difference in expression according to differentiation of SCC, but not grade of dysplasia. As VEGF is a potent mediator of vascular development, these results suggest that VEGF may play an important role in the maintenance of a blood supply for developing pre-cancerous and invasive oral lesions. |
| doi_str_mv | 10.1016/j.ijom.2006.09.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68996599</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0901502706004383</els_id><sourcerecordid>68996599</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-2a70ed655357e68cff0dde62c37d81c96772b75451827b23b8b44b5685aed6c53</originalsourceid><addsrcrecordid>eNp9kU-L1TAUxYsoznP0C7iQrETB1pu0SRoYBBnejMKAC_9sQ5qkTmqbvEna0bfxs5vSB4ILN7kk95zDze8WxXMMFQbM3g6VG8JUEQBWgagA8wfFDtdClAAEHhY7EIBLCoSfFU9SGgBA1C1_XJxhjhvccLIrfu9_HaJNyQWPQo_uVdLLqCKy3oT51o5Ojeh7DD_nW9QrPYeIXn3bX1-9Rs4jH-KU2yHmY1p0SOrNdjHHdBhVcgopb7andLeoKSwJaTuOSKuonQ-Telo86tWY7LNTPS--Xu2_XH4obz5df7x8f1PqhtO5JIqDNYzSmnLLWt33YIxlRNfctFgLxjnpOG0obgnvSN21XdN0lLVUZZum9Xnxcss9xHC32DTLyaV1FOVtnkqyVghGhchCsgl1DClF28tDdJOKR4lBrtTlIFfqcqUuQchMPZtenNKXbrLmr-WEOQsuNoHNf7x3NsqknfXaGhetnqUJ7v_57_6x69F5p9X4wx5tGsISfaYnsUxEgvy87n1dOzCApm7r-g_bmKmD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68996599</pqid></control><display><type>article</type><title>Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Johnstone, S ; Logan, R.M</creator><creatorcontrib>Johnstone, S ; Logan, R.M</creatorcontrib><description>Abstract Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine implicated in tumour vasculogenesis. A significant increase in vascularity occurs during the transition from normal oral mucosa (NOM), through dysplasia, to squamous cell carcinoma (SCC). This study investigated the presence of VEGF in NOM, oral dysplasia and SCC. The correlation between VEGF expression and the grade of dysplasia or differentiation of SCC was also examined. Specimens consisting of NOM, oral dysplastic lesions and oral SCC were stained using standard immunohistochemistry methods to determine VEGF expression. Statistical analysis indicated an up-regulation of VEGF during the transition from NOM, through dysplasia to SCC. There was also a significant difference in expression according to differentiation of SCC, but not grade of dysplasia. As VEGF is a potent mediator of vascular development, these results suggest that VEGF may play an important role in the maintenance of a blood supply for developing pre-cancerous and invasive oral lesions.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2006.09.017</identifier><identifier>PMID: 17141472</identifier><language>eng</language><publisher>Denmark: Elsevier Ltd</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Case-Control Studies ; Cell Differentiation ; Cell Transformation, Neoplastic ; Dentistry ; Female ; Humans ; Immunoenzyme Techniques ; Male ; Middle Aged ; Mouth Mucosa - metabolism ; Mouth Mucosa - pathology ; Mouth Neoplasms - blood supply ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Neoplasm Invasiveness ; Neovascularization, Pathologic ; oral cancer ; oral dysplasia ; Precancerous Conditions - blood supply ; Precancerous Conditions - metabolism ; Precancerous Conditions - pathology ; squamous cell carcinoma ; Statistics, Nonparametric ; Surgery ; Up-Regulation ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - biosynthesis</subject><ispartof>International journal of oral and maxillofacial surgery, 2007-03, Vol.36 (3), p.263-266</ispartof><rights>International Association of Oral and Maxillofacial Surgeons</rights><rights>2006 International Association of Oral and Maxillofacial Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-2a70ed655357e68cff0dde62c37d81c96772b75451827b23b8b44b5685aed6c53</citedby><cites>FETCH-LOGICAL-c475t-2a70ed655357e68cff0dde62c37d81c96772b75451827b23b8b44b5685aed6c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijom.2006.09.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17141472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnstone, S</creatorcontrib><creatorcontrib>Logan, R.M</creatorcontrib><title>Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>Abstract Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine implicated in tumour vasculogenesis. A significant increase in vascularity occurs during the transition from normal oral mucosa (NOM), through dysplasia, to squamous cell carcinoma (SCC). This study investigated the presence of VEGF in NOM, oral dysplasia and SCC. The correlation between VEGF expression and the grade of dysplasia or differentiation of SCC was also examined. Specimens consisting of NOM, oral dysplastic lesions and oral SCC were stained using standard immunohistochemistry methods to determine VEGF expression. Statistical analysis indicated an up-regulation of VEGF during the transition from NOM, through dysplasia to SCC. There was also a significant difference in expression according to differentiation of SCC, but not grade of dysplasia. As VEGF is a potent mediator of vascular development, these results suggest that VEGF may play an important role in the maintenance of a blood supply for developing pre-cancerous and invasive oral lesions.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Case-Control Studies</subject><subject>Cell Differentiation</subject><subject>Cell Transformation, Neoplastic</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - metabolism</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - blood supply</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Invasiveness</subject><subject>Neovascularization, Pathologic</subject><subject>oral cancer</subject><subject>oral dysplasia</subject><subject>Precancerous Conditions - blood supply</subject><subject>Precancerous Conditions - metabolism</subject><subject>Precancerous Conditions - pathology</subject><subject>squamous cell carcinoma</subject><subject>Statistics, Nonparametric</subject><subject>Surgery</subject><subject>Up-Regulation</subject><subject>vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - biosynthesis</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-L1TAUxYsoznP0C7iQrETB1pu0SRoYBBnejMKAC_9sQ5qkTmqbvEna0bfxs5vSB4ILN7kk95zDze8WxXMMFQbM3g6VG8JUEQBWgagA8wfFDtdClAAEHhY7EIBLCoSfFU9SGgBA1C1_XJxhjhvccLIrfu9_HaJNyQWPQo_uVdLLqCKy3oT51o5Ojeh7DD_nW9QrPYeIXn3bX1-9Rs4jH-KU2yHmY1p0SOrNdjHHdBhVcgopb7andLeoKSwJaTuOSKuonQ-Telo86tWY7LNTPS--Xu2_XH4obz5df7x8f1PqhtO5JIqDNYzSmnLLWt33YIxlRNfctFgLxjnpOG0obgnvSN21XdN0lLVUZZum9Xnxcss9xHC32DTLyaV1FOVtnkqyVghGhchCsgl1DClF28tDdJOKR4lBrtTlIFfqcqUuQchMPZtenNKXbrLmr-WEOQsuNoHNf7x3NsqknfXaGhetnqUJ7v_57_6x69F5p9X4wx5tGsISfaYnsUxEgvy87n1dOzCApm7r-g_bmKmD</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Johnstone, S</creator><creator>Logan, R.M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma</title><author>Johnstone, S ; Logan, R.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-2a70ed655357e68cff0dde62c37d81c96772b75451827b23b8b44b5685aed6c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Case-Control Studies</topic><topic>Cell Differentiation</topic><topic>Cell Transformation, Neoplastic</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - metabolism</topic><topic>Mouth Mucosa - pathology</topic><topic>Mouth Neoplasms - blood supply</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Invasiveness</topic><topic>Neovascularization, Pathologic</topic><topic>oral cancer</topic><topic>oral dysplasia</topic><topic>Precancerous Conditions - blood supply</topic><topic>Precancerous Conditions - metabolism</topic><topic>Precancerous Conditions - pathology</topic><topic>squamous cell carcinoma</topic><topic>Statistics, Nonparametric</topic><topic>Surgery</topic><topic>Up-Regulation</topic><topic>vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnstone, S</creatorcontrib><creatorcontrib>Logan, R.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnstone, S</au><au>Logan, R.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>36</volume><issue>3</issue><spage>263</spage><epage>266</epage><pages>263-266</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><abstract>Abstract Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine implicated in tumour vasculogenesis. A significant increase in vascularity occurs during the transition from normal oral mucosa (NOM), through dysplasia, to squamous cell carcinoma (SCC). This study investigated the presence of VEGF in NOM, oral dysplasia and SCC. The correlation between VEGF expression and the grade of dysplasia or differentiation of SCC was also examined. Specimens consisting of NOM, oral dysplastic lesions and oral SCC were stained using standard immunohistochemistry methods to determine VEGF expression. Statistical analysis indicated an up-regulation of VEGF during the transition from NOM, through dysplasia to SCC. There was also a significant difference in expression according to differentiation of SCC, but not grade of dysplasia. As VEGF is a potent mediator of vascular development, these results suggest that VEGF may play an important role in the maintenance of a blood supply for developing pre-cancerous and invasive oral lesions.</abstract><cop>Denmark</cop><pub>Elsevier Ltd</pub><pmid>17141472</pmid><doi>10.1016/j.ijom.2006.09.017</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0901-5027 |
| ispartof | International journal of oral and maxillofacial surgery, 2007-03, Vol.36 (3), p.263-266 |
| issn | 0901-5027 1399-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68996599 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Case-Control Studies Cell Differentiation Cell Transformation, Neoplastic Dentistry Female Humans Immunoenzyme Techniques Male Middle Aged Mouth Mucosa - metabolism Mouth Mucosa - pathology Mouth Neoplasms - blood supply Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Invasiveness Neovascularization, Pathologic oral cancer oral dysplasia Precancerous Conditions - blood supply Precancerous Conditions - metabolism Precancerous Conditions - pathology squamous cell carcinoma Statistics, Nonparametric Surgery Up-Regulation vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis |
| title | Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A54%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20vascular%20endothelial%20growth%20factor%20(VEGF)%20in%20normal%20oral%20mucosa,%20oral%20dysplasia%20and%20oral%20squamous%20cell%20carcinoma&rft.jtitle=International%20journal%20of%20oral%20and%20maxillofacial%20surgery&rft.au=Johnstone,%20S&rft.date=2007-03-01&rft.volume=36&rft.issue=3&rft.spage=263&rft.epage=266&rft.pages=263-266&rft.issn=0901-5027&rft.eissn=1399-0020&rft_id=info:doi/10.1016/j.ijom.2006.09.017&rft_dat=%3Cproquest_cross%3E68996599%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68996599&rft_id=info:pmid/17141472&rft_els_id=S0901502706004383&rfr_iscdi=true |