Parity and Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities study
OBJECTIVE:--While high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas. Our objectives were to estimate the magnitude of association between parity and diabetes and to dete...
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| Veröffentlicht in: | Diabetes care 2006-11, Vol.29 (11), p.2349-2354 |
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| creator | Nicholson, Wanda K Asao, Keiko Brancati, Frederick Coresh, Josef Pankow, James S Powe, Neil R |
| description | OBJECTIVE:--While high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas. Our objectives were to estimate the magnitude of association between parity and diabetes and to determine if higher parity is predictive of future risk of diabetes. RESEARCH DESIGN AND METHODS--This was a population-based, prospective cohort study of 7,024 Caucasian and African-American women from the Atherosclerosis Risk in Communities study, a prospective epidemiological study of men and women aged 45-64 years, with 9 years of follow-up. Incident diabetes was defined by the 1997 American Diabetes Association diagnostic criteria. Parity was defined as the number of live births (no live births [nulliparity], one to two live births, three to four live births, and five or more live births [grandmultiparity]). Parity and risk of diabetes was estimated for 754 incident cases of diabetes with Cox proportional hazard regression models, adjusting for sociodemographic, clinical, and lifestyle factors and inflammatory markers. RESULTS:--Incidence rates were highest among women with five or more live births (23/1,000 person-years [95% CI 20.3-26.7]) and lowest among women with one to two live births (11/1,000 person-years [9.6-12.5]). Adjustment indicated that much of the risk was due to sociodemographic factors and higher obesity, but after adjustment for all covariates, grandmultiparity (five or more) was still associated with a 27% increased risk for diabetes (hazard ratio 1.27 [95% CI 1.02-1.57]). CONCLUSIONS:--Grandmultiparity is predictive of future risk of diabetes after adjustment for confounders. |
| doi_str_mv | 10.2337/dc06-0825 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68995793</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A154561170</galeid><sourcerecordid>A154561170</sourcerecordid><originalsourceid>FETCH-LOGICAL-f367t-ba5f63b6cd79261d2c08d8f6af7be08072c23ffc9d820a0fb2f1a55b4b975e5f3</originalsourceid><addsrcrecordid>eNpt0UuLFDEQAOAgijuOHvwDGgS99ZpHJ-nsbRifsOBr9tykk8ps1u5kTLoP8--NzIggm0AKwpeiKoXQc0ouGefqrbNENqRj4gFaUc1FI0TbPUQrQlvdCK3ZBXpSyh0hpG277jG6oIpIIaVcoW9fTQ7zEZvo8PdQfuLk8e54AMzwu2AGmKFc4d0t4M18CzkVO_45QznhEPE2TdMSwxyg4DIv7vgUPfJmLPDsHNfo5sP73fZTc_3l4-ft5rrxXKq5GYzwkg_SOqWZpI5Z0rnOS-PVAKQjilnGvbfadYwY4gfmqRFiaAetBAjP1-jNKe8hp18LlLmfQrEwjiZCWkovO62F0rzCV__Bu7TkWGvrGeOEM6pURc0J7c0IfYg-zdnYPUTIZkwRfKjXGypaIWn9veov7_F1O5iCvffBi3MVyzCB6w85TCYf-7-jqOD1GZhizeiziTaUf66Ot9W1nzV6eXLepN7sczU3PxihnNC6uOT8N8qYneg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223032177</pqid></control><display><type>article</type><title>Parity and Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Nicholson, Wanda K ; Asao, Keiko ; Brancati, Frederick ; Coresh, Josef ; Pankow, James S ; Powe, Neil R</creator><creatorcontrib>Nicholson, Wanda K ; Asao, Keiko ; Brancati, Frederick ; Coresh, Josef ; Pankow, James S ; Powe, Neil R</creatorcontrib><description>OBJECTIVE:--While high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas. Our objectives were to estimate the magnitude of association between parity and diabetes and to determine if higher parity is predictive of future risk of diabetes. RESEARCH DESIGN AND METHODS--This was a population-based, prospective cohort study of 7,024 Caucasian and African-American women from the Atherosclerosis Risk in Communities study, a prospective epidemiological study of men and women aged 45-64 years, with 9 years of follow-up. Incident diabetes was defined by the 1997 American Diabetes Association diagnostic criteria. Parity was defined as the number of live births (no live births [nulliparity], one to two live births, three to four live births, and five or more live births [grandmultiparity]). Parity and risk of diabetes was estimated for 754 incident cases of diabetes with Cox proportional hazard regression models, adjusting for sociodemographic, clinical, and lifestyle factors and inflammatory markers. RESULTS:--Incidence rates were highest among women with five or more live births (23/1,000 person-years [95% CI 20.3-26.7]) and lowest among women with one to two live births (11/1,000 person-years [9.6-12.5]). Adjustment indicated that much of the risk was due to sociodemographic factors and higher obesity, but after adjustment for all covariates, grandmultiparity (five or more) was still associated with a 27% increased risk for diabetes (hazard ratio 1.27 [95% CI 1.02-1.57]). CONCLUSIONS:--Grandmultiparity is predictive of future risk of diabetes after adjustment for confounders.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc06-0825</identifier><identifier>PMID: 17065666</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Atherosclerosis ; Atherosclerosis - epidemiology ; Behavior ; Biological and medical sciences ; Birth control ; Cardiovascular disease ; Diabetes ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Health aspects ; Humans ; Incidence ; Medical sciences ; Middle Aged ; Obesity - epidemiology ; Parity ; Predictive Value of Tests ; Pregnancy ; Proportional Hazards Models ; Prospective Studies ; Reproductive health ; Risk Factors ; Socioeconomic factors ; Type 2 diabetes ; Women ; Womens health</subject><ispartof>Diabetes care, 2006-11, Vol.29 (11), p.2349-2354</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2006 American Diabetes Association</rights><rights>Copyright American Diabetes Association Nov 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18254979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17065666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nicholson, Wanda K</creatorcontrib><creatorcontrib>Asao, Keiko</creatorcontrib><creatorcontrib>Brancati, Frederick</creatorcontrib><creatorcontrib>Coresh, Josef</creatorcontrib><creatorcontrib>Pankow, James S</creatorcontrib><creatorcontrib>Powe, Neil R</creatorcontrib><title>Parity and Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE:--While high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas. Our objectives were to estimate the magnitude of association between parity and diabetes and to determine if higher parity is predictive of future risk of diabetes. RESEARCH DESIGN AND METHODS--This was a population-based, prospective cohort study of 7,024 Caucasian and African-American women from the Atherosclerosis Risk in Communities study, a prospective epidemiological study of men and women aged 45-64 years, with 9 years of follow-up. Incident diabetes was defined by the 1997 American Diabetes Association diagnostic criteria. Parity was defined as the number of live births (no live births [nulliparity], one to two live births, three to four live births, and five or more live births [grandmultiparity]). Parity and risk of diabetes was estimated for 754 incident cases of diabetes with Cox proportional hazard regression models, adjusting for sociodemographic, clinical, and lifestyle factors and inflammatory markers. RESULTS:--Incidence rates were highest among women with five or more live births (23/1,000 person-years [95% CI 20.3-26.7]) and lowest among women with one to two live births (11/1,000 person-years [9.6-12.5]). Adjustment indicated that much of the risk was due to sociodemographic factors and higher obesity, but after adjustment for all covariates, grandmultiparity (five or more) was still associated with a 27% increased risk for diabetes (hazard ratio 1.27 [95% CI 1.02-1.57]). CONCLUSIONS:--Grandmultiparity is predictive of future risk of diabetes after adjustment for confounders.</description><subject>Atherosclerosis</subject><subject>Atherosclerosis - epidemiology</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Cardiovascular disease</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - epidemiology</subject><subject>Parity</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Reproductive health</subject><subject>Risk Factors</subject><subject>Socioeconomic factors</subject><subject>Type 2 diabetes</subject><subject>Women</subject><subject>Womens health</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0UuLFDEQAOAgijuOHvwDGgS99ZpHJ-nsbRifsOBr9tykk8ps1u5kTLoP8--NzIggm0AKwpeiKoXQc0ouGefqrbNENqRj4gFaUc1FI0TbPUQrQlvdCK3ZBXpSyh0hpG277jG6oIpIIaVcoW9fTQ7zEZvo8PdQfuLk8e54AMzwu2AGmKFc4d0t4M18CzkVO_45QznhEPE2TdMSwxyg4DIv7vgUPfJmLPDsHNfo5sP73fZTc_3l4-ft5rrxXKq5GYzwkg_SOqWZpI5Z0rnOS-PVAKQjilnGvbfadYwY4gfmqRFiaAetBAjP1-jNKe8hp18LlLmfQrEwjiZCWkovO62F0rzCV__Bu7TkWGvrGeOEM6pURc0J7c0IfYg-zdnYPUTIZkwRfKjXGypaIWn9veov7_F1O5iCvffBi3MVyzCB6w85TCYf-7-jqOD1GZhizeiziTaUf66Ot9W1nzV6eXLepN7sczU3PxihnNC6uOT8N8qYneg</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Nicholson, Wanda K</creator><creator>Asao, Keiko</creator><creator>Brancati, Frederick</creator><creator>Coresh, Josef</creator><creator>Pankow, James S</creator><creator>Powe, Neil R</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Parity and Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities study</title><author>Nicholson, Wanda K ; Asao, Keiko ; Brancati, Frederick ; Coresh, Josef ; Pankow, James S ; Powe, Neil R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f367t-ba5f63b6cd79261d2c08d8f6af7be08072c23ffc9d820a0fb2f1a55b4b975e5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Atherosclerosis</topic><topic>Atherosclerosis - epidemiology</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Cardiovascular disease</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - epidemiology</topic><topic>Parity</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Reproductive health</topic><topic>Risk Factors</topic><topic>Socioeconomic factors</topic><topic>Type 2 diabetes</topic><topic>Women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicholson, Wanda K</creatorcontrib><creatorcontrib>Asao, Keiko</creatorcontrib><creatorcontrib>Brancati, Frederick</creatorcontrib><creatorcontrib>Coresh, Josef</creatorcontrib><creatorcontrib>Pankow, James S</creatorcontrib><creatorcontrib>Powe, Neil R</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicholson, Wanda K</au><au>Asao, Keiko</au><au>Brancati, Frederick</au><au>Coresh, Josef</au><au>Pankow, James S</au><au>Powe, Neil R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parity and Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>29</volume><issue>11</issue><spage>2349</spage><epage>2354</epage><pages>2349-2354</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE:--While high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas. Our objectives were to estimate the magnitude of association between parity and diabetes and to determine if higher parity is predictive of future risk of diabetes. RESEARCH DESIGN AND METHODS--This was a population-based, prospective cohort study of 7,024 Caucasian and African-American women from the Atherosclerosis Risk in Communities study, a prospective epidemiological study of men and women aged 45-64 years, with 9 years of follow-up. Incident diabetes was defined by the 1997 American Diabetes Association diagnostic criteria. Parity was defined as the number of live births (no live births [nulliparity], one to two live births, three to four live births, and five or more live births [grandmultiparity]). Parity and risk of diabetes was estimated for 754 incident cases of diabetes with Cox proportional hazard regression models, adjusting for sociodemographic, clinical, and lifestyle factors and inflammatory markers. RESULTS:--Incidence rates were highest among women with five or more live births (23/1,000 person-years [95% CI 20.3-26.7]) and lowest among women with one to two live births (11/1,000 person-years [9.6-12.5]). Adjustment indicated that much of the risk was due to sociodemographic factors and higher obesity, but after adjustment for all covariates, grandmultiparity (five or more) was still associated with a 27% increased risk for diabetes (hazard ratio 1.27 [95% CI 1.02-1.57]). CONCLUSIONS:--Grandmultiparity is predictive of future risk of diabetes after adjustment for confounders.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>17065666</pmid><doi>10.2337/dc06-0825</doi><tpages>6</tpages></addata></record> |
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| subjects | Atherosclerosis Atherosclerosis - epidemiology Behavior Biological and medical sciences Birth control Cardiovascular disease Diabetes Diabetes Mellitus, Type 2 - epidemiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Health aspects Humans Incidence Medical sciences Middle Aged Obesity - epidemiology Parity Predictive Value of Tests Pregnancy Proportional Hazards Models Prospective Studies Reproductive health Risk Factors Socioeconomic factors Type 2 diabetes Women Womens health |
| title | Parity and Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities study |
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