Mini review: immune response to myelin-derived sulfatide and CNS-demyelination
Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. T...
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| Veröffentlicht in: | Neurochemical research 2007-02, Vol.32 (2), p.257-262 |
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| creator | Halder, Ramesh C Jahng, A Maricic, I Kumar, Vipin |
| description | Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. The results of studies we have obtained so far in investigating the presentation of sulfatide by CNS-resident cells including microglia and their interactions with T cells indicate that this pathway might be successfully targeted for the treatment of autoimmune demyelination in multiple sclerosis. |
| doi_str_mv | 10.1007/s11064-006-9145-4 |
| format | Article |
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| issn | 0364-3190 1573-6903 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Antigens, CD1 - physiology Demyelinating Autoimmune Diseases, CNS - immunology Encephalomyelitis, Autoimmune, Experimental - immunology Galactosylceramides - immunology Glycolipids - immunology Humans Killer Cells, Natural - immunology Mice Multiple Sclerosis - immunology Sulfoglycosphingolipids - immunology T-Lymphocytes - immunology |
| title | Mini review: immune response to myelin-derived sulfatide and CNS-demyelination |
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