Activation of PPAR-δ in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids

GW501516, an agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta), increases lipid combustion and exerts antidiabetic action in animals, effects which are attributed mainly to direct effects on skeletal muscle. We explored such actions further in isolated rat skeletal muscle. Spe...

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Veröffentlicht in:	Diabetologia 2006-11, Vol.49 (11), p.2713-2722
Hauptverfasser:	BRUNMAIR, B, STANIEK, K, FÜRNSINN, C, DÖRIG, J, SZÖCS, Z, STADLBAUER, K, MARIAN, V, GRAS, F, ANDERWALD, C, NOHL, H, WALDHÄUSL, W
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases Animals Biological and medical sciences Diabetes. Impaired glucose tolerance Dietary Carbohydrates Dietary Fats Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids - metabolism Food Preferences Fundamental and applied biological sciences. Psychology Glucose - metabolism Insulin - physiology Kinetics Male Medical sciences Mitochondria, Muscle - metabolism Multienzyme Complexes - metabolism Muscle, Skeletal - physiology PPAR delta - physiology Protein-Serine-Threonine Kinases - metabolism Rats Rats, Sprague-Dawley Striated muscle. Tendons Thiazoles - pharmacology Vertebrates: osteoarticular system, musculoskeletal system
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