Effect of post-natal castration on sepsis mortality in rats
To investigate the influence of castration in early periods of development on survival to experimental acute sepsis. Four groups of 10 (ten) Wistar rats were used. The groups were comprised of males (M), females (F), males castrated on the fourth day of life (CM) and males castrated on the fourth da...
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| Veröffentlicht in: | Acta cirúrgica brasileira 2007-01, Vol.22 (1), p.22-29 |
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| creator | Bernhardt, Joel Antonio d'Acampora, Armando José Tramonte, Ricardo Serafim, João Daniel May |
| description | To investigate the influence of castration in early periods of development on survival to experimental acute sepsis.
Four groups of 10 (ten) Wistar rats were used. The groups were comprised of males (M), females (F), males castrated on the fourth day of life (CM) and males castrated on the fourth day of life with testosterone replacement (CMR). Sepsis was induced by ligature and cecal perforation in adult life.
The analysis of death within 24 hours following sepsis induction showed greater mortality between the M and the CMR groups as compared to the CM and F (p=0.0180) groups. Multiple correspondence analysis (MCA) indicates an association between the M and the CMR groups for death within 24 hours as well as a relationship between the F and the CM groups for the absence of death and death up to 24 hours following sepsis induction. Statistical analysis of the Kaplan-Meier survival curve through log-rank demonstrates a significant difference among the four groups (p=0.0055) and between the M and the F (p=0.0005) groups.
Data suggest a better survival to sepsis within 24 hours for the F and CM groups, the presence or absence of testosterone in early periods of post-natal life being responsible for these findings. |
| doi_str_mv | 10.1590/S0102-86502007000100004 |
| format | Article |
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Four groups of 10 (ten) Wistar rats were used. The groups were comprised of males (M), females (F), males castrated on the fourth day of life (CM) and males castrated on the fourth day of life with testosterone replacement (CMR). Sepsis was induced by ligature and cecal perforation in adult life.
The analysis of death within 24 hours following sepsis induction showed greater mortality between the M and the CMR groups as compared to the CM and F (p=0.0180) groups. Multiple correspondence analysis (MCA) indicates an association between the M and the CMR groups for death within 24 hours as well as a relationship between the F and the CM groups for the absence of death and death up to 24 hours following sepsis induction. Statistical analysis of the Kaplan-Meier survival curve through log-rank demonstrates a significant difference among the four groups (p=0.0055) and between the M and the F (p=0.0005) groups.
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Four groups of 10 (ten) Wistar rats were used. The groups were comprised of males (M), females (F), males castrated on the fourth day of life (CM) and males castrated on the fourth day of life with testosterone replacement (CMR). Sepsis was induced by ligature and cecal perforation in adult life.
The analysis of death within 24 hours following sepsis induction showed greater mortality between the M and the CMR groups as compared to the CM and F (p=0.0180) groups. Multiple correspondence analysis (MCA) indicates an association between the M and the CMR groups for death within 24 hours as well as a relationship between the F and the CM groups for the absence of death and death up to 24 hours following sepsis induction. Statistical analysis of the Kaplan-Meier survival curve through log-rank demonstrates a significant difference among the four groups (p=0.0055) and between the M and the F (p=0.0005) groups.
Data suggest a better survival to sepsis within 24 hours for the F and CM groups, the presence or absence of testosterone in early periods of post-natal life being responsible for these findings.</description><subject>Animals</subject><subject>Animals, Newborn - surgery</subject><subject>Chi-Square Distribution</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Kaplan-Meier Estimate</subject><subject>Ligation</subject><subject>Male</subject><subject>Orchiectomy - mortality</subject><subject>Peritonitis - complications</subject><subject>Peritonitis - immunology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sepsis - immunology</subject><subject>Sepsis - mortality</subject><subject>Sex Factors</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Testosterone - administration & dosage</subject><subject>Time Factors</subject><issn>0102-8650</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUE1LBDEMLaK4uvoXtCdvo-m0M53gSZb1AxY8qOfS7bQwMl9Ouof991Z3UcEQSMJ7LyGPsUsB16JAuHkBAXlWlQXkABogjSnUATv5AQ7_9DN2SvSeWKoU8pjNhM5RoipO2O0yBO8iHwIfB4pZb6NtubMUJxuboecpyY_UEO-GKWFN3PKm5wmlM3YUbEv-fF_n7O1--bp4zFbPD0-Lu1XmJGLMUGivtcsr79ZSVcoVUBdOBVzXmLu8RnBaghbpsboOGlA7rKXOS8AyWFRyzq52e8dp-Nh4iqZryPm2tb0fNmTKClEqLRJR74huGogmH8w4NZ2dtkaA-fLNfPtm_vmWlBf7E5t15-tf3d4o-QmVQWdO</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Bernhardt, Joel Antonio</creator><creator>d'Acampora, Armando José</creator><creator>Tramonte, Ricardo</creator><creator>Serafim, João Daniel May</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Effect of post-natal castration on sepsis mortality in rats</title><author>Bernhardt, Joel Antonio ; d'Acampora, Armando José ; Tramonte, Ricardo ; Serafim, João Daniel May</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-917e77c28ecb3484c50d5c4f9bd92c2d90c73071159ddf7097c9d3726096fa943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Animals, Newborn - surgery</topic><topic>Chi-Square Distribution</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Kaplan-Meier Estimate</topic><topic>Ligation</topic><topic>Male</topic><topic>Orchiectomy - mortality</topic><topic>Peritonitis - complications</topic><topic>Peritonitis - immunology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sepsis - immunology</topic><topic>Sepsis - mortality</topic><topic>Sex Factors</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Testosterone - administration & dosage</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernhardt, Joel Antonio</creatorcontrib><creatorcontrib>d'Acampora, Armando José</creatorcontrib><creatorcontrib>Tramonte, Ricardo</creatorcontrib><creatorcontrib>Serafim, João Daniel May</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cirúrgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernhardt, Joel Antonio</au><au>d'Acampora, Armando José</au><au>Tramonte, Ricardo</au><au>Serafim, João Daniel May</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of post-natal castration on sepsis mortality in rats</atitle><jtitle>Acta cirúrgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>22</volume><issue>1</issue><spage>22</spage><epage>29</epage><pages>22-29</pages><issn>0102-8650</issn><eissn>0102-8650</eissn><abstract>To investigate the influence of castration in early periods of development on survival to experimental acute sepsis.
Four groups of 10 (ten) Wistar rats were used. The groups were comprised of males (M), females (F), males castrated on the fourth day of life (CM) and males castrated on the fourth day of life with testosterone replacement (CMR). Sepsis was induced by ligature and cecal perforation in adult life.
The analysis of death within 24 hours following sepsis induction showed greater mortality between the M and the CMR groups as compared to the CM and F (p=0.0180) groups. Multiple correspondence analysis (MCA) indicates an association between the M and the CMR groups for death within 24 hours as well as a relationship between the F and the CM groups for the absence of death and death up to 24 hours following sepsis induction. Statistical analysis of the Kaplan-Meier survival curve through log-rank demonstrates a significant difference among the four groups (p=0.0055) and between the M and the F (p=0.0005) groups.
Data suggest a better survival to sepsis within 24 hours for the F and CM groups, the presence or absence of testosterone in early periods of post-natal life being responsible for these findings.</abstract><cop>Brazil</cop><pmid>17293945</pmid><doi>10.1590/S0102-86502007000100004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Animals, Newborn - surgery Chi-Square Distribution Disease Models, Animal Female Kaplan-Meier Estimate Ligation Male Orchiectomy - mortality Peritonitis - complications Peritonitis - immunology Rats Rats, Wistar Sepsis - immunology Sepsis - mortality Sex Factors Survival Analysis Survival Rate Testosterone - administration & dosage Time Factors |
| title | Effect of post-natal castration on sepsis mortality in rats |
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