Chemical biology of steroid and nuclear hormone receptors

The nuclear hormone receptors are ligand-gated transcription factors that modulate gene expression by directly acting upon genomic DNA, and have been of profound interest across all biological disciplines. Recent advancements in this area have included the expansion of transgene activation through l...

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Veröffentlicht in:	Current opinion in chemical biology 2007-02, Vol.11 (1), p.99-110
Hauptverfasser:	Biggins, John B, Koh, John T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA - genetics DNA - metabolism Drug Design Gene Expression Regulation - genetics Gene Expression Regulation - physiology Humans Ligands Models, Biological Models, Molecular Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Proteins Steroids - chemistry Steroids - metabolism Transcription Factors - genetics Transcription Factors - physiology Transgenes - genetics Transgenes - physiology
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