Chemical biology of steroid and nuclear hormone receptors
The nuclear hormone receptors are ligand-gated transcription factors that modulate gene expression by directly acting upon genomic DNA, and have been of profound interest across all biological disciplines. Recent advancements in this area have included the expansion of transgene activation through l...
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| Veröffentlicht in: | Current opinion in chemical biology 2007-02, Vol.11 (1), p.99-110 |
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| container_title | Current opinion in chemical biology |
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| creator | Biggins, John B Koh, John T |
| description | The nuclear hormone receptors are ligand-gated transcription factors that modulate gene expression by directly acting upon genomic DNA, and have been of profound interest across all biological disciplines. Recent advancements in this area have included the expansion of transgene activation through ligand–receptor engineering, drug development from structural design and the exploitation of innate ligand-specific associations towards developing novel conditional protein-based recombinant and diagnostic tools. These advancements come on the heels of exciting new modes of hormone action that challenge and expand upon the classic paradigms of hormone receptor function. |
| doi_str_mv | 10.1016/j.cbpa.2006.10.042 |
| format | Article |
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| identifier | ISSN: 1367-5931 |
| ispartof | Current opinion in chemical biology, 2007-02, Vol.11 (1), p.99-110 |
| issn | 1367-5931 1879-0402 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals DNA - genetics DNA - metabolism Drug Design Gene Expression Regulation - genetics Gene Expression Regulation - physiology Humans Ligands Models, Biological Models, Molecular Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Proteins Steroids - chemistry Steroids - metabolism Transcription Factors - genetics Transcription Factors - physiology Transgenes - genetics Transgenes - physiology |
| title | Chemical biology of steroid and nuclear hormone receptors |
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