Preparation of thin polymer films with drug release and protein adsorption resistance
We prepared the silicon surface modified with a block copolymer of poly( N-isopropylacrylamide) (p(AAm)) and poly(2-methoxyethyl methacrylate) (p(MEMA)) and evaluated the ability of the surface to release drug and resist protein adsorption. ▪ Thin polymer films with the ability of both drug release...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2007-03, Vol.55 (1), p.19-25 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Tsukagoshi, Tatsuya Kondo, Yukishige Yoshino, Norio |
| description | We prepared the silicon surface modified with a block copolymer of poly(
N-isopropylacrylamide) (p(AAm)) and poly(2-methoxyethyl methacrylate) (p(MEMA)) and evaluated the ability of the surface to release drug and resist protein adsorption.
▪
Thin polymer films with the ability of both drug release and protein adsorption resistance were formed on silicon substrates and silica particles. The films were made of a block copolymer of poly(
N-isopropylacrylamide) (p(AAm)) that can load and release drugs and poly(2-methoxyethyl methacrylate) (p(MEMA)) that can suppress protein adsorption. Aspirin and bovine serum albumin were respectively used as model substances for testing the abilities of the films to load and release drugs and to suppress protein adsorption. The films were immersed in a phosphate buffer saline (pH 7.4) for 100 days to evaluate their water resistance. The experimental results showed that the films have both drug release and protein adsorption resistance and are highly stable against PBS. |
| doi_str_mv | 10.1016/j.colsurfb.2006.10.038 |
| format | Article |
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N-isopropylacrylamide) (p(AAm)) and poly(2-methoxyethyl methacrylate) (p(MEMA)) and evaluated the ability of the surface to release drug and resist protein adsorption.
▪
Thin polymer films with the ability of both drug release and protein adsorption resistance were formed on silicon substrates and silica particles. The films were made of a block copolymer of poly(
N-isopropylacrylamide) (p(AAm)) that can load and release drugs and poly(2-methoxyethyl methacrylate) (p(MEMA)) that can suppress protein adsorption. Aspirin and bovine serum albumin were respectively used as model substances for testing the abilities of the films to load and release drugs and to suppress protein adsorption. The films were immersed in a phosphate buffer saline (pH 7.4) for 100 days to evaluate their water resistance. The experimental results showed that the films have both drug release and protein adsorption resistance and are highly stable against PBS.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2006.10.038</identifier><identifier>PMID: 17161591</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acrylic Resins - chemistry ; Adsorption ; Aspirin - chemistry ; Drug Carriers - chemistry ; Drug Compounding - methods ; Drug release ; Drug Stability ; Membranes, Artificial ; Molecular Structure ; Particle Size ; Polymethacrylic Acids - chemistry ; Protein adsorption ; Serum Albumin, Bovine - chemistry ; Silane coupling agent ; Silicon - chemistry ; Silicon Dioxide - chemistry ; Surface initiated polymerization ; Surface modification ; Surface Properties</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2007-03, Vol.55 (1), p.19-25</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-ae725aeded6c84f1f73a24765a4b9cd5fa50562791ed7aeadb89b92c11513f523</citedby><cites>FETCH-LOGICAL-c397t-ae725aeded6c84f1f73a24765a4b9cd5fa50562791ed7aeadb89b92c11513f523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2006.10.038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17161591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsukagoshi, Tatsuya</creatorcontrib><creatorcontrib>Kondo, Yukishige</creatorcontrib><creatorcontrib>Yoshino, Norio</creatorcontrib><title>Preparation of thin polymer films with drug release and protein adsorption resistance</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>We prepared the silicon surface modified with a block copolymer of poly(
N-isopropylacrylamide) (p(AAm)) and poly(2-methoxyethyl methacrylate) (p(MEMA)) and evaluated the ability of the surface to release drug and resist protein adsorption.
▪
Thin polymer films with the ability of both drug release and protein adsorption resistance were formed on silicon substrates and silica particles. The films were made of a block copolymer of poly(
N-isopropylacrylamide) (p(AAm)) that can load and release drugs and poly(2-methoxyethyl methacrylate) (p(MEMA)) that can suppress protein adsorption. Aspirin and bovine serum albumin were respectively used as model substances for testing the abilities of the films to load and release drugs and to suppress protein adsorption. The films were immersed in a phosphate buffer saline (pH 7.4) for 100 days to evaluate their water resistance. The experimental results showed that the films have both drug release and protein adsorption resistance and are highly stable against PBS.</description><subject>Acrylic Resins - chemistry</subject><subject>Adsorption</subject><subject>Aspirin - chemistry</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Compounding - methods</subject><subject>Drug release</subject><subject>Drug Stability</subject><subject>Membranes, Artificial</subject><subject>Molecular Structure</subject><subject>Particle Size</subject><subject>Polymethacrylic Acids - chemistry</subject><subject>Protein adsorption</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>Silane coupling agent</subject><subject>Silicon - chemistry</subject><subject>Silicon Dioxide - chemistry</subject><subject>Surface initiated polymerization</subject><subject>Surface modification</subject><subject>Surface Properties</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhq2Kqiy0r4B84patx0ns-AZC0FZCag_lbDn2uHiVxKmdgHj7eruLOHIa6df3z4w-Qi6AbYGB-Lrb2jjkNfl-yxkTJdyyuvtANtDJumpqIU_IhikuKylFe0rOct4xxngD8hM5BQkCWgUb8vAr4WySWUKcaPR0eQwTnePwMmKiPgxjps9heaQurX9owgFNRmomR-cUFyyscTmm-X89YQ55MZPFz-SjN0PGL8d5Th7ubn_ffK_uf377cXN9X9layaUyKHlr0KETtms8eFkb3pR_TdMr61pvWtYKLhWgkwaN6zvVK24BWqh9y-tzcnnYW775u2Je9BiyxWEwE8Y1a9EpxQHYuyBnkjeqlgUUB9CmmHNCr-cURpNeNDC9N693-tW83pvf58V8KV4cL6z9iO6tdlRdgKsDgEXIU8Cksw1YZLmQ0C7axfDejX-otJn7</recordid><startdate>20070315</startdate><enddate>20070315</enddate><creator>Tsukagoshi, Tatsuya</creator><creator>Kondo, Yukishige</creator><creator>Yoshino, Norio</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070315</creationdate><title>Preparation of thin polymer films with drug release and protein adsorption resistance</title><author>Tsukagoshi, Tatsuya ; Kondo, Yukishige ; Yoshino, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-ae725aeded6c84f1f73a24765a4b9cd5fa50562791ed7aeadb89b92c11513f523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acrylic Resins - chemistry</topic><topic>Adsorption</topic><topic>Aspirin - chemistry</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Compounding - methods</topic><topic>Drug release</topic><topic>Drug Stability</topic><topic>Membranes, Artificial</topic><topic>Molecular Structure</topic><topic>Particle Size</topic><topic>Polymethacrylic Acids - chemistry</topic><topic>Protein adsorption</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>Silane coupling agent</topic><topic>Silicon - chemistry</topic><topic>Silicon Dioxide - chemistry</topic><topic>Surface initiated polymerization</topic><topic>Surface modification</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsukagoshi, Tatsuya</creatorcontrib><creatorcontrib>Kondo, Yukishige</creatorcontrib><creatorcontrib>Yoshino, Norio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsukagoshi, Tatsuya</au><au>Kondo, Yukishige</au><au>Yoshino, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of thin polymer films with drug release and protein adsorption resistance</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2007-03-15</date><risdate>2007</risdate><volume>55</volume><issue>1</issue><spage>19</spage><epage>25</epage><pages>19-25</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>We prepared the silicon surface modified with a block copolymer of poly(
N-isopropylacrylamide) (p(AAm)) and poly(2-methoxyethyl methacrylate) (p(MEMA)) and evaluated the ability of the surface to release drug and resist protein adsorption.
▪
Thin polymer films with the ability of both drug release and protein adsorption resistance were formed on silicon substrates and silica particles. The films were made of a block copolymer of poly(
N-isopropylacrylamide) (p(AAm)) that can load and release drugs and poly(2-methoxyethyl methacrylate) (p(MEMA)) that can suppress protein adsorption. Aspirin and bovine serum albumin were respectively used as model substances for testing the abilities of the films to load and release drugs and to suppress protein adsorption. The films were immersed in a phosphate buffer saline (pH 7.4) for 100 days to evaluate their water resistance. The experimental results showed that the films have both drug release and protein adsorption resistance and are highly stable against PBS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17161591</pmid><doi>10.1016/j.colsurfb.2006.10.038</doi><tpages>7</tpages></addata></record> |
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| ispartof | Colloids and surfaces, B, Biointerfaces, 2007-03, Vol.55 (1), p.19-25 |
| issn | 0927-7765 1873-4367 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Acrylic Resins - chemistry Adsorption Aspirin - chemistry Drug Carriers - chemistry Drug Compounding - methods Drug release Drug Stability Membranes, Artificial Molecular Structure Particle Size Polymethacrylic Acids - chemistry Protein adsorption Serum Albumin, Bovine - chemistry Silane coupling agent Silicon - chemistry Silicon Dioxide - chemistry Surface initiated polymerization Surface modification Surface Properties |
| title | Preparation of thin polymer films with drug release and protein adsorption resistance |
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