Tumor microvascular architecture phenotype (T-MAP) as a new concept for studies of angiogenesis and oncology
Heterogeneities exist in endothelial cells and microvascular architecture during tumor angiogenesis. We found significantly variable expression profiles of EC markers, including ephrinB2 and its receptor EphB4, and various types of the architecture. We propose a new concept of tumor microvascular ar...
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| Veröffentlicht in: | Journal of neuro-oncology 2006-11, Vol.80 (2), p.211-213 |
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| container_title | Journal of neuro-oncology |
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| creator | BIAN, Xiu-Wu WANG, Qing-Liang XIAO, Hua-Liang JI MING WANG |
| description | Heterogeneities exist in endothelial cells and microvascular architecture during tumor angiogenesis. We found significantly variable expression profiles of EC markers, including ephrinB2 and its receptor EphB4, and various types of the architecture. We propose a new concept of tumor microvascular architecture phenotype (T-MAP), reflecting the density, morphology, structure and the three-dimensional distribution of newly formed vessels. The pattern of T-MAP may represent the invasiveness of the tumor therefore predict the outcome of therapy. The presence of T-MAP heterogeneity (T-MAPH) may be utilized as additional diagnostic criteria and for therapeutic designs for antiangiogenesis. |
| doi_str_mv | 10.1007/s11060-006-9167-4 |
| format | Article |
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Prion diseases ; Glioma - blood supply ; Glioma - pathology ; Human viral diseases ; Humans ; Immunohistochemistry ; Infectious diseases ; Medical sciences ; Neoplasms - blood supply ; Neoplasms - parasitology ; Neovascularization, Pathologic - pathology ; Neurology ; Phenotype ; Regional Blood Flow - physiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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We found significantly variable expression profiles of EC markers, including ephrinB2 and its receptor EphB4, and various types of the architecture. We propose a new concept of tumor microvascular architecture phenotype (T-MAP), reflecting the density, morphology, structure and the three-dimensional distribution of newly formed vessels. The pattern of T-MAP may represent the invasiveness of the tumor therefore predict the outcome of therapy. The presence of T-MAP heterogeneity (T-MAPH) may be utilized as additional diagnostic criteria and for therapeutic designs for antiangiogenesis.</description><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - blood supply</subject><subject>Brain Neoplasms - pathology</subject><subject>Capillaries - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Leukodystrophies. Prion diseases</topic><topic>Glioma - blood supply</topic><topic>Glioma - pathology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Neoplasms - blood supply</topic><topic>Neoplasms - parasitology</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Neurology</topic><topic>Phenotype</topic><topic>Regional Blood Flow - physiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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| subjects | Biological and medical sciences Brain Neoplasms - blood supply Brain Neoplasms - pathology Capillaries - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Glioma - blood supply Glioma - pathology Human viral diseases Humans Immunohistochemistry Infectious diseases Medical sciences Neoplasms - blood supply Neoplasms - parasitology Neovascularization, Pathologic - pathology Neurology Phenotype Regional Blood Flow - physiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Tumor microvascular architecture phenotype (T-MAP) as a new concept for studies of angiogenesis and oncology |
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