Copper-Catalyzed Multicomponent Cascade Process for the Synthesis of Hexahydro-1H-isoindolones

Copper-Catalyzed Multicomponent Cascade Process for the Synthesis of Hexahydro-1H-isoindolones

Copper-catalyzed coupling of imines, dienylstannanes, and acryloyl chlorides followed by a Diels−Alder reaction afforded hexahydro-1H-isoindolones. Diversification of the core via Pd-catalyzed cross-coupling defines a new modular approach to isoindolone combinatorial libraries.

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Veröffentlicht in:Journal of organic chemistry 2007-02, Vol.72 (4), p.1484-1487
Hauptverfasser: Zhang, Lei, Malinakova, Helena C
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chemistry
Copper - chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Indoles - chemical synthesis
Molecular Structure
Organic chemistry
Preparations and properties
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Beschreibung
Zusammenfassung:Copper-catalyzed coupling of imines, dienylstannanes, and acryloyl chlorides followed by a Diels−Alder reaction afforded hexahydro-1H-isoindolones. Diversification of the core via Pd-catalyzed cross-coupling defines a new modular approach to isoindolone combinatorial libraries.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo0621773