Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation
Prostacyclin (PGI(2)) stimulates adenyl cyclase to synthesize cAMP within the vascular smooth muscle resulting in vasodilatation. Milrinone inhibits cAMP clearance by phosphodiesterase type III. We studied the dose response of pulmonary and systemic hemodynamics to intratracheal (IT) PGI(2) in newbo...
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| Veröffentlicht in: | Pediatric research 2006-11, Vol.60 (5), p.624-629 |
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| creator | RASHID, Nasir MORIN, Frederick C SWARTZ, Daniel D RYAN, Rita M WYNN, Karen A HUAMEI WANG LAKSHMINRUSIMHA, Satyan KUMAR, Vasanth H |
| description | Prostacyclin (PGI(2)) stimulates adenyl cyclase to synthesize cAMP within the vascular smooth muscle resulting in vasodilatation. Milrinone inhibits cAMP clearance by phosphodiesterase type III. We studied the dose response of pulmonary and systemic hemodynamics to intratracheal (IT) PGI(2) in newborn lambs with pulmonary hypertension (PH) and whether intravenous milrinone potentiate these effects. IT-PGI(2) at varying doses was administered to lambs with PH induced by prenatal ductal ligation. IT-PGI(2) doses were repeated in the presence of intravenous milrinone (bolus-100 microg/kg followed by infusion at 1 microg/kg/min). Increasing doses of IT-PGI(2) significantly decreased mean pulmonary arterial pressures (PAP) and pulmonary vascular resistance (PVR) and increased pulmonary blood flow (PBF). Intravenous milrinone by itself produced a significant reduction in PVR and a significant increase in PBF. Intravenous milrinone significantly shortened the onset, prolonged the duration and degree of pulmonary vasodilation produced by PGI(2). We conclude that intravenous milrinone potentiates the pulmonary vasodilator effects of PGI(2) at lower doses. |
| doi_str_mv | 10.1203/01.pdr.0000242343.84510.81 |
| format | Article |
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Milrinone inhibits cAMP clearance by phosphodiesterase type III. We studied the dose response of pulmonary and systemic hemodynamics to intratracheal (IT) PGI(2) in newborn lambs with pulmonary hypertension (PH) and whether intravenous milrinone potentiate these effects. IT-PGI(2) at varying doses was administered to lambs with PH induced by prenatal ductal ligation. IT-PGI(2) doses were repeated in the presence of intravenous milrinone (bolus-100 microg/kg followed by infusion at 1 microg/kg/min). Increasing doses of IT-PGI(2) significantly decreased mean pulmonary arterial pressures (PAP) and pulmonary vascular resistance (PVR) and increased pulmonary blood flow (PBF). Intravenous milrinone by itself produced a significant reduction in PVR and a significant increase in PBF. Intravenous milrinone significantly shortened the onset, prolonged the duration and degree of pulmonary vasodilation produced by PGI(2). We conclude that intravenous milrinone potentiates the pulmonary vasodilator effects of PGI(2) at lower doses.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/01.pdr.0000242343.84510.81</identifier><identifier>PMID: 16988189</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Ductus Arteriosus - surgery ; Epoprostenol - pharmacology ; Fetus - anatomy & histology ; Fetus - physiology ; Fetus - surgery ; General aspects ; Humans ; Hypertension, Pulmonary - metabolism ; Hypertension, Pulmonary - physiopathology ; Medical sciences ; Milrinone - pharmacology ; Phosphodiesterase Inhibitors - pharmacology ; Pneumology ; Pulmonary Circulation - drug effects ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Random Allocation ; Sheep</subject><ispartof>Pediatric research, 2006-11, Vol.60 (5), p.624-629</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-6427663937ba97ad5f742be39fb3e231b8a2a4f0a24baca09abb7dec213e37be3</citedby><cites>FETCH-LOGICAL-c347t-6427663937ba97ad5f742be39fb3e231b8a2a4f0a24baca09abb7dec213e37be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18224594$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16988189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RASHID, Nasir</creatorcontrib><creatorcontrib>MORIN, Frederick C</creatorcontrib><creatorcontrib>SWARTZ, Daniel D</creatorcontrib><creatorcontrib>RYAN, Rita M</creatorcontrib><creatorcontrib>WYNN, Karen A</creatorcontrib><creatorcontrib>HUAMEI WANG</creatorcontrib><creatorcontrib>LAKSHMINRUSIMHA, Satyan</creatorcontrib><creatorcontrib>KUMAR, Vasanth H</creatorcontrib><title>Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>Prostacyclin (PGI(2)) stimulates adenyl cyclase to synthesize cAMP within the vascular smooth muscle resulting in vasodilatation. Milrinone inhibits cAMP clearance by phosphodiesterase type III. We studied the dose response of pulmonary and systemic hemodynamics to intratracheal (IT) PGI(2) in newborn lambs with pulmonary hypertension (PH) and whether intravenous milrinone potentiate these effects. IT-PGI(2) at varying doses was administered to lambs with PH induced by prenatal ductal ligation. IT-PGI(2) doses were repeated in the presence of intravenous milrinone (bolus-100 microg/kg followed by infusion at 1 microg/kg/min). Increasing doses of IT-PGI(2) significantly decreased mean pulmonary arterial pressures (PAP) and pulmonary vascular resistance (PVR) and increased pulmonary blood flow (PBF). Intravenous milrinone by itself produced a significant reduction in PVR and a significant increase in PBF. Intravenous milrinone significantly shortened the onset, prolonged the duration and degree of pulmonary vasodilation produced by PGI(2). We conclude that intravenous milrinone potentiates the pulmonary vasodilator effects of PGI(2) at lower doses.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Ductus Arteriosus - surgery</subject><subject>Epoprostenol - pharmacology</subject><subject>Fetus - anatomy & histology</subject><subject>Fetus - physiology</subject><subject>Fetus - surgery</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - metabolism</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Medical sciences</subject><subject>Milrinone - pharmacology</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Pneumology</subject><subject>Pulmonary Circulation - drug effects</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Random Allocation</subject><subject>Sheep</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkcuKFTEQhoMozvHoK0gQdNfH3Lo7cSfDeIEBN7oOlXTiRNLpNkkz9GvMExudA8fapKj6_gpVP0JvKDlRRvh7Qk_rlE-kBROMC36Som9NSZ-gA-056YgQ41N0IITTjislr9CLUn4RQkUvxXN0RQclJZXqgB5uvHe2Frx4vOalVLC7jSFhSBOeQ8whLcnhJeF1i_OSIO_4zs3LtCeYgy24ocndmyUnHGE2Bd-HeodXl0so1aX6v25v5VYroY0Ladqsm7DZcUsqRBzDT6it9RI98xCLe3V-j-jHp5vv11-622-fv15_vO0sF2PtBsHGYeCKjwbUCFPvR8GM48ob7hinRgID4QkwYcACUWDMODnLKHdN4_gRvXuc2_b-vblS9RyKdTFCcstW9CCVIkO75xF9eARtO1DJzus1h7ltpCnRfx3RhOrmiL44ov85oiVt4tfnXzYzu-kiPVvQgLdnAIqF6DMkG8qFk4yJXgn-B5pCmmM</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>RASHID, Nasir</creator><creator>MORIN, Frederick C</creator><creator>SWARTZ, Daniel D</creator><creator>RYAN, Rita M</creator><creator>WYNN, Karen A</creator><creator>HUAMEI WANG</creator><creator>LAKSHMINRUSIMHA, Satyan</creator><creator>KUMAR, Vasanth H</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation</title><author>RASHID, Nasir ; MORIN, Frederick C ; SWARTZ, Daniel D ; RYAN, Rita M ; WYNN, Karen A ; HUAMEI WANG ; LAKSHMINRUSIMHA, Satyan ; KUMAR, Vasanth H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-6427663937ba97ad5f742be39fb3e231b8a2a4f0a24baca09abb7dec213e37be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Ductus Arteriosus - surgery</topic><topic>Epoprostenol - pharmacology</topic><topic>Fetus - anatomy & histology</topic><topic>Fetus - physiology</topic><topic>Fetus - surgery</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - metabolism</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Medical sciences</topic><topic>Milrinone - pharmacology</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Pneumology</topic><topic>Pulmonary Circulation - drug effects</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Random Allocation</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RASHID, Nasir</creatorcontrib><creatorcontrib>MORIN, Frederick C</creatorcontrib><creatorcontrib>SWARTZ, Daniel D</creatorcontrib><creatorcontrib>RYAN, Rita M</creatorcontrib><creatorcontrib>WYNN, Karen A</creatorcontrib><creatorcontrib>HUAMEI WANG</creatorcontrib><creatorcontrib>LAKSHMINRUSIMHA, Satyan</creatorcontrib><creatorcontrib>KUMAR, Vasanth H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RASHID, Nasir</au><au>MORIN, Frederick C</au><au>SWARTZ, Daniel D</au><au>RYAN, Rita M</au><au>WYNN, Karen A</au><au>HUAMEI WANG</au><au>LAKSHMINRUSIMHA, Satyan</au><au>KUMAR, Vasanth H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>60</volume><issue>5</issue><spage>624</spage><epage>629</epage><pages>624-629</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Prostacyclin (PGI(2)) stimulates adenyl cyclase to synthesize cAMP within the vascular smooth muscle resulting in vasodilatation. Milrinone inhibits cAMP clearance by phosphodiesterase type III. We studied the dose response of pulmonary and systemic hemodynamics to intratracheal (IT) PGI(2) in newborn lambs with pulmonary hypertension (PH) and whether intravenous milrinone potentiate these effects. IT-PGI(2) at varying doses was administered to lambs with PH induced by prenatal ductal ligation. IT-PGI(2) doses were repeated in the presence of intravenous milrinone (bolus-100 microg/kg followed by infusion at 1 microg/kg/min). Increasing doses of IT-PGI(2) significantly decreased mean pulmonary arterial pressures (PAP) and pulmonary vascular resistance (PVR) and increased pulmonary blood flow (PBF). Intravenous milrinone by itself produced a significant reduction in PVR and a significant increase in PBF. Intravenous milrinone significantly shortened the onset, prolonged the duration and degree of pulmonary vasodilation produced by PGI(2). We conclude that intravenous milrinone potentiates the pulmonary vasodilator effects of PGI(2) at lower doses.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16988189</pmid><doi>10.1203/01.pdr.0000242343.84510.81</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Animals Animals, Newborn Biological and medical sciences Ductus Arteriosus - surgery Epoprostenol - pharmacology Fetus - anatomy & histology Fetus - physiology Fetus - surgery General aspects Humans Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - physiopathology Medical sciences Milrinone - pharmacology Phosphodiesterase Inhibitors - pharmacology Pneumology Pulmonary Circulation - drug effects Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Random Allocation Sheep |
| title | Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation |
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