A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

For over 35 years, immunologists have divided T-helper (T(H)) cells into functional subsets. T-helper type 1 (T(H)1) cells-long thought to mediate tissue damage-might be involved in the initiation of damage, but they do not sustain or play a decisive role in many commonly studied models of autoimmun...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature medicine 2007-02, Vol.13 (2), p.139-145
1. Verfasser: Steinman, Lawrence
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 145
container_issue 2
container_start_page 139
container_title Nature medicine
container_volume 13
creator Steinman, Lawrence
description For over 35 years, immunologists have divided T-helper (T(H)) cells into functional subsets. T-helper type 1 (T(H)1) cells-long thought to mediate tissue damage-might be involved in the initiation of damage, but they do not sustain or play a decisive role in many commonly studied models of autoimmunity, allergy and microbial immunity. A major role for the cytokine interleukin-17 (IL-17) has now been described in various models of immune-mediated tissue injury, including organ-specific autoimmunity in the brain, heart, synovium and intestines, allergic disorders of the lung and skin, and microbial infections of the intestines and the nervous system. A pathway named T(H)17 is now credited for causing and sustaining tissue damage in these diverse situations. The T(H)1 pathway antagonizes the T(H)17 pathway in an intricate fashion. The evolution of our understanding of the T(H)17 pathway illuminates a shift in immunologists' perspectives regarding the basis of tissue damage, where for over 20 years the role of T(H)1 cells was considered paramount.
doi_str_mv 10.1038/nm1551
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68990469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68990469</sourcerecordid><originalsourceid>FETCH-LOGICAL-p139t-96384518328e3e0eca9e722a1ea0eacdb3ae1721312427b93ab6807400a40d9e3</originalsourceid><addsrcrecordid>eNo1kMFOwzAQRH0A0VLgE5BPCCRC13YS28eqAopUiUs5R06zoa6aONgOUv--aSmXXWn2aTSzhNwxeGEg1LRtWJaxCzJmIFWidJaPyHUIWwAQkOkrMmKSa-CSj4mf0dJbrOnGhuj8nrqarh4XT0w-07hBWlsfIm3M1nnq8dcG61pq29PtxE2Pk9PNvnODFmw4OdA17nZJg5U1ESsabQg90so05htvyGVtdgFvz3tCvt5eV_NFsvx8_5jPlknHhI6JzoVKM6YEVygQcG00Ss4NQwNo1lUpDA49mGA85bLUwpS5ApkCmBQqjWJCHv58O-9-egyxaGw45jItuj4UudIa0lwP4P0Z7MshctF52xi_L_6_JA7vEWNJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68990469</pqid></control><display><type>article</type><title>A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><creator>Steinman, Lawrence</creator><creatorcontrib>Steinman, Lawrence</creatorcontrib><description>For over 35 years, immunologists have divided T-helper (T(H)) cells into functional subsets. T-helper type 1 (T(H)1) cells-long thought to mediate tissue damage-might be involved in the initiation of damage, but they do not sustain or play a decisive role in many commonly studied models of autoimmunity, allergy and microbial immunity. A major role for the cytokine interleukin-17 (IL-17) has now been described in various models of immune-mediated tissue injury, including organ-specific autoimmunity in the brain, heart, synovium and intestines, allergic disorders of the lung and skin, and microbial infections of the intestines and the nervous system. A pathway named T(H)17 is now credited for causing and sustaining tissue damage in these diverse situations. The T(H)1 pathway antagonizes the T(H)17 pathway in an intricate fashion. The evolution of our understanding of the T(H)17 pathway illuminates a shift in immunologists' perspectives regarding the basis of tissue damage, where for over 20 years the role of T(H)1 cells was considered paramount.</description><identifier>ISSN: 1078-8956</identifier><identifier>DOI: 10.1038/nm1551</identifier><identifier>PMID: 17290272</identifier><language>eng</language><publisher>United States</publisher><subject>Autoimmune Diseases - immunology ; Cell Differentiation ; Gene Expression Regulation ; Humans ; Hypersensitivity - immunology ; Infection - immunology ; Interleukin-17 - immunology ; Interleukin-17 - metabolism ; Models, Immunological ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Helper-Inducer - metabolism</subject><ispartof>Nature medicine, 2007-02, Vol.13 (2), p.139-145</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17290272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinman, Lawrence</creatorcontrib><title>A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><description>For over 35 years, immunologists have divided T-helper (T(H)) cells into functional subsets. T-helper type 1 (T(H)1) cells-long thought to mediate tissue damage-might be involved in the initiation of damage, but they do not sustain or play a decisive role in many commonly studied models of autoimmunity, allergy and microbial immunity. A major role for the cytokine interleukin-17 (IL-17) has now been described in various models of immune-mediated tissue injury, including organ-specific autoimmunity in the brain, heart, synovium and intestines, allergic disorders of the lung and skin, and microbial infections of the intestines and the nervous system. A pathway named T(H)17 is now credited for causing and sustaining tissue damage in these diverse situations. The T(H)1 pathway antagonizes the T(H)17 pathway in an intricate fashion. The evolution of our understanding of the T(H)17 pathway illuminates a shift in immunologists' perspectives regarding the basis of tissue damage, where for over 20 years the role of T(H)1 cells was considered paramount.</description><subject>Autoimmune Diseases - immunology</subject><subject>Cell Differentiation</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Infection - immunology</subject><subject>Interleukin-17 - immunology</subject><subject>Interleukin-17 - metabolism</subject><subject>Models, Immunological</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><issn>1078-8956</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMFOwzAQRH0A0VLgE5BPCCRC13YS28eqAopUiUs5R06zoa6aONgOUv--aSmXXWn2aTSzhNwxeGEg1LRtWJaxCzJmIFWidJaPyHUIWwAQkOkrMmKSa-CSj4mf0dJbrOnGhuj8nrqarh4XT0w-07hBWlsfIm3M1nnq8dcG61pq29PtxE2Pk9PNvnODFmw4OdA17nZJg5U1ESsabQg90so05htvyGVtdgFvz3tCvt5eV_NFsvx8_5jPlknHhI6JzoVKM6YEVygQcG00Ss4NQwNo1lUpDA49mGA85bLUwpS5ApkCmBQqjWJCHv58O-9-egyxaGw45jItuj4UudIa0lwP4P0Z7MshctF52xi_L_6_JA7vEWNJ</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Steinman, Lawrence</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage</title><author>Steinman, Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-96384518328e3e0eca9e722a1ea0eacdb3ae1721312427b93ab6807400a40d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Autoimmune Diseases - immunology</topic><topic>Cell Differentiation</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Infection - immunology</topic><topic>Interleukin-17 - immunology</topic><topic>Interleukin-17 - metabolism</topic><topic>Models, Immunological</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinman, Lawrence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinman, Lawrence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage</atitle><jtitle>Nature medicine</jtitle><addtitle>Nat Med</addtitle><date>2007-02</date><risdate>2007</risdate><volume>13</volume><issue>2</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>1078-8956</issn><abstract>For over 35 years, immunologists have divided T-helper (T(H)) cells into functional subsets. T-helper type 1 (T(H)1) cells-long thought to mediate tissue damage-might be involved in the initiation of damage, but they do not sustain or play a decisive role in many commonly studied models of autoimmunity, allergy and microbial immunity. A major role for the cytokine interleukin-17 (IL-17) has now been described in various models of immune-mediated tissue injury, including organ-specific autoimmunity in the brain, heart, synovium and intestines, allergic disorders of the lung and skin, and microbial infections of the intestines and the nervous system. A pathway named T(H)17 is now credited for causing and sustaining tissue damage in these diverse situations. The T(H)1 pathway antagonizes the T(H)17 pathway in an intricate fashion. The evolution of our understanding of the T(H)17 pathway illuminates a shift in immunologists' perspectives regarding the basis of tissue damage, where for over 20 years the role of T(H)1 cells was considered paramount.</abstract><cop>United States</cop><pmid>17290272</pmid><doi>10.1038/nm1551</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1078-8956
ispartof Nature medicine, 2007-02, Vol.13 (2), p.139-145
issn 1078-8956
language eng
recordid cdi_proquest_miscellaneous_68990469
source MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online
subjects Autoimmune Diseases - immunology
Cell Differentiation
Gene Expression Regulation
Humans
Hypersensitivity - immunology
Infection - immunology
Interleukin-17 - immunology
Interleukin-17 - metabolism
Models, Immunological
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
title A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T19%3A26%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20brief%20history%20of%20T(H)17,%20the%20first%20major%20revision%20in%20the%20T(H)1/T(H)2%20hypothesis%20of%20T%20cell-mediated%20tissue%20damage&rft.jtitle=Nature%20medicine&rft.au=Steinman,%20Lawrence&rft.date=2007-02&rft.volume=13&rft.issue=2&rft.spage=139&rft.epage=145&rft.pages=139-145&rft.issn=1078-8956&rft_id=info:doi/10.1038/nm1551&rft_dat=%3Cproquest_pubme%3E68990469%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68990469&rft_id=info:pmid/17290272&rfr_iscdi=true