International quality control survey of neurochemical dementia diagnostics
Currently, neurochemical dementia diagnostics (NDD) are increasingly entering routine clinical neurochemistry, offering improved early and differential diagnosis of dementias. However, there is an obvious lack of standardization in pre-analytical sample handling and systematic quality surveys. There...
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| Veröffentlicht in: | Neuroscience letters 2006-11, Vol.409 (1), p.1-4 |
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| creator | Lewczuk, Piotr Beck, Georg Ganslandt, Oliver Esselmann, Hermann Deisenhammer, Florian Regeniter, Axel Petereit, Hela-Felicitas Tumani, Hayrettin Gerritzen, Andreas Oschmann, Patrick Schröder, Johannes Schönknecht, Peter Zimmermann, Klaus Hampel, Harald Bürger, Katharina Otto, Markus Haustein, Sabine Herzog, Karin Dannenberg, Rainer Wurster, Ulrich Bibl, Mirko Maler, Juan Manuel Reubach, Udo Kornhuber, Johannes Wiltfang, Jens |
| description | Currently, neurochemical dementia diagnostics (NDD) are increasingly entering routine clinical neurochemistry, offering improved early and differential diagnosis of dementias. However, there is an obvious lack of standardization in pre-analytical sample handling and systematic quality surveys. Therefore, in this study, 14 laboratories in Germany, Austria, and Switzerland were given aliquots of a human cerebrospinal fluid (CSF) sample, and were asked to measure Alzheimer's disease (AD) biomarkers (amyloid β (Aβ) peptides, total Tau protein, and phosphorylated Tau protein (P-tau
181P)) according to their routine protocols.
Results: The inter-laboratory coefficients of variation of the results obtained by the laboratories participating in this study were in the range of 20–30%. Although the results of this quality control survey are promising, the quality of measurements has to be further optimized. |
| doi_str_mv | 10.1016/j.neulet.2006.07.009 |
| format | Article |
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181P)) according to their routine protocols.
Results: The inter-laboratory coefficients of variation of the results obtained by the laboratories participating in this study were in the range of 20–30%. Although the results of this quality control survey are promising, the quality of measurements has to be further optimized.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2006.07.009</identifier><identifier>PMID: 17045397</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Amyloid ; Amyloid beta-Peptides - cerebrospinal fluid ; Biological and medical sciences ; Biomarkers ; Cerebrospinal fluid ; Clinical Laboratory Techniques - standards ; Data Collection ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diagnosis, Differential ; Europe ; Fundamental and applied biological sciences. Psychology ; Humans ; Indicators and Reagents ; Medical sciences ; Neurology ; Phosphorylation ; Quality Control ; Reproducibility of Results ; Tau ; tau Proteins - cerebrospinal fluid ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2006-11, Vol.409 (1), p.1-4</ispartof><rights>2006 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-a5b7324d733cdba755d4bc279c950005975c91b1fcfd2b1ebe043b3566ac85c53</citedby><cites>FETCH-LOGICAL-c444t-a5b7324d733cdba755d4bc279c950005975c91b1fcfd2b1ebe043b3566ac85c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394006006768$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18239802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17045397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewczuk, Piotr</creatorcontrib><creatorcontrib>Beck, Georg</creatorcontrib><creatorcontrib>Ganslandt, Oliver</creatorcontrib><creatorcontrib>Esselmann, Hermann</creatorcontrib><creatorcontrib>Deisenhammer, Florian</creatorcontrib><creatorcontrib>Regeniter, Axel</creatorcontrib><creatorcontrib>Petereit, Hela-Felicitas</creatorcontrib><creatorcontrib>Tumani, Hayrettin</creatorcontrib><creatorcontrib>Gerritzen, Andreas</creatorcontrib><creatorcontrib>Oschmann, Patrick</creatorcontrib><creatorcontrib>Schröder, Johannes</creatorcontrib><creatorcontrib>Schönknecht, Peter</creatorcontrib><creatorcontrib>Zimmermann, Klaus</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><creatorcontrib>Bürger, Katharina</creatorcontrib><creatorcontrib>Otto, Markus</creatorcontrib><creatorcontrib>Haustein, Sabine</creatorcontrib><creatorcontrib>Herzog, Karin</creatorcontrib><creatorcontrib>Dannenberg, Rainer</creatorcontrib><creatorcontrib>Wurster, Ulrich</creatorcontrib><creatorcontrib>Bibl, Mirko</creatorcontrib><creatorcontrib>Maler, Juan Manuel</creatorcontrib><creatorcontrib>Reubach, Udo</creatorcontrib><creatorcontrib>Kornhuber, Johannes</creatorcontrib><creatorcontrib>Wiltfang, Jens</creatorcontrib><title>International quality control survey of neurochemical dementia diagnostics</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Currently, neurochemical dementia diagnostics (NDD) are increasingly entering routine clinical neurochemistry, offering improved early and differential diagnosis of dementias. However, there is an obvious lack of standardization in pre-analytical sample handling and systematic quality surveys. Therefore, in this study, 14 laboratories in Germany, Austria, and Switzerland were given aliquots of a human cerebrospinal fluid (CSF) sample, and were asked to measure Alzheimer's disease (AD) biomarkers (amyloid β (Aβ) peptides, total Tau protein, and phosphorylated Tau protein (P-tau
181P)) according to their routine protocols.
Results: The inter-laboratory coefficients of variation of the results obtained by the laboratories participating in this study were in the range of 20–30%. Although the results of this quality control survey are promising, the quality of measurements has to be further optimized.</description><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease</subject><subject>Amyloid</subject><subject>Amyloid beta-Peptides - cerebrospinal fluid</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cerebrospinal fluid</subject><subject>Clinical Laboratory Techniques - standards</subject><subject>Data Collection</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diagnosis, Differential</subject><subject>Europe</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Phosphorylation</subject><subject>Quality Control</subject><subject>Reproducibility of Results</subject><subject>Tau</subject><subject>tau Proteins - cerebrospinal fluid</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAURa0K1A6FP0AoG9glPMd2HG-QUEVLUSU2sLYc-wU8SuzWdirN3-PRjNQdq7c5976rQ8h7Ch0FOnzedwG3BUvXAwwdyA5AXZAdHWXfSiX7V2QHDHjLFIcr8ibnPQAIKvgluaISuGBK7siP-1AwBVN8DGZpnjaz-HJobAwlxaXJW3rGQxPnpj5L0f7F1dvKOVwxFG8a582fEHPxNr8lr2ezZHx3vtfk9-23Xzff24efd_c3Xx9ayzkvrRGTZD13kjHrJiOFcHyyvVRWieNCJYVVdKKznV0_UZwQOJuYGAZjR2EFuyafTr2PKT5tmItefba4LCZg3LIeRjUqxWQF-Qm0KeaccNaPya8mHTQFfXSo9_rkUB8dapC6OqyxD-f-bVrRvYTO0irw8QyYXGXMyQTr8ws39kyN0Ffuy4nDauPZY9LZegwWnU9oi3bR_3_JP4eukvk</recordid><startdate>20061127</startdate><enddate>20061127</enddate><creator>Lewczuk, Piotr</creator><creator>Beck, Georg</creator><creator>Ganslandt, Oliver</creator><creator>Esselmann, Hermann</creator><creator>Deisenhammer, Florian</creator><creator>Regeniter, Axel</creator><creator>Petereit, Hela-Felicitas</creator><creator>Tumani, Hayrettin</creator><creator>Gerritzen, Andreas</creator><creator>Oschmann, Patrick</creator><creator>Schröder, Johannes</creator><creator>Schönknecht, Peter</creator><creator>Zimmermann, Klaus</creator><creator>Hampel, Harald</creator><creator>Bürger, Katharina</creator><creator>Otto, Markus</creator><creator>Haustein, Sabine</creator><creator>Herzog, Karin</creator><creator>Dannenberg, Rainer</creator><creator>Wurster, Ulrich</creator><creator>Bibl, Mirko</creator><creator>Maler, Juan Manuel</creator><creator>Reubach, Udo</creator><creator>Kornhuber, Johannes</creator><creator>Wiltfang, Jens</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061127</creationdate><title>International quality control survey of neurochemical dementia diagnostics</title><author>Lewczuk, Piotr ; Beck, Georg ; Ganslandt, Oliver ; Esselmann, Hermann ; Deisenhammer, Florian ; Regeniter, Axel ; Petereit, Hela-Felicitas ; Tumani, Hayrettin ; Gerritzen, Andreas ; Oschmann, Patrick ; Schröder, Johannes ; Schönknecht, Peter ; Zimmermann, Klaus ; Hampel, Harald ; Bürger, Katharina ; Otto, Markus ; Haustein, Sabine ; Herzog, Karin ; Dannenberg, Rainer ; Wurster, Ulrich ; Bibl, Mirko ; Maler, Juan Manuel ; Reubach, Udo ; Kornhuber, Johannes ; Wiltfang, Jens</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-a5b7324d733cdba755d4bc279c950005975c91b1fcfd2b1ebe043b3566ac85c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alzheimer Disease - cerebrospinal fluid</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease</topic><topic>Amyloid</topic><topic>Amyloid beta-Peptides - cerebrospinal fluid</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cerebrospinal fluid</topic><topic>Clinical Laboratory Techniques - standards</topic><topic>Data Collection</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. 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However, there is an obvious lack of standardization in pre-analytical sample handling and systematic quality surveys. Therefore, in this study, 14 laboratories in Germany, Austria, and Switzerland were given aliquots of a human cerebrospinal fluid (CSF) sample, and were asked to measure Alzheimer's disease (AD) biomarkers (amyloid β (Aβ) peptides, total Tau protein, and phosphorylated Tau protein (P-tau
181P)) according to their routine protocols.
Results: The inter-laboratory coefficients of variation of the results obtained by the laboratories participating in this study were in the range of 20–30%. Although the results of this quality control survey are promising, the quality of measurements has to be further optimized.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17045397</pmid><doi>10.1016/j.neulet.2006.07.009</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience letters, 2006-11, Vol.409 (1), p.1-4 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| subjects | Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Alzheimer's disease Amyloid Amyloid beta-Peptides - cerebrospinal fluid Biological and medical sciences Biomarkers Cerebrospinal fluid Clinical Laboratory Techniques - standards Data Collection Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis, Differential Europe Fundamental and applied biological sciences. Psychology Humans Indicators and Reagents Medical sciences Neurology Phosphorylation Quality Control Reproducibility of Results Tau tau Proteins - cerebrospinal fluid Vertebrates: nervous system and sense organs |
| title | International quality control survey of neurochemical dementia diagnostics |
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