Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss

: We report here that dysregulation of CD19, a coreceptor that augments B-cell receptor (BCR) signaling, occurs at two B-cell differentiative stages in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic autoantibody (ANCA) associated small vessel vasculitis (SVV). The na...

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Veröffentlicht in:	Journal of Clinical Immunology 2007-01, Vol.27 (1), p.53-68
Hauptverfasser:	Culton, Donna A, Nicholas, Matilda W, Bunch, Donna O, Zhen, Quan Li, Kepler, Thomas B, Dooley, Mary Anne, Mohan, Chandra, Nachman, Patrick H, Clarke, Stephen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Antineutrophil Cytoplasmic - immunology Antigens, CD19 - immunology Autoantibodies - analysis Autoimmune Diseases B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology Female Flow Cytometry Glomerulonephritis - immunology Humans Immune Tolerance Lupus Erythematosus, Systemic - immunology Lupus Nephritis - immunology Lymphocyte Activation Male Middle Aged Protein Array Analysis - methods Vasculitis - immunology
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