Human CYP11A1 promoter drives Cre recombinase expression in the brain in addition to adrenals and gonads

The first step of steroid biosynthesis is catalyzed by cytochrome P450scc, encoded by CYP11A1. To achieve steroidogenic tissue‐specific inactivation of genes in vivo by the Cre‐loxP approach, we used the 4.4‐kb regulatory region of the human CYP11A1 gene to drive Cre recombinase expression in the ti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2007-02, Vol.45 (2), p.59-65
Hauptverfasser:	Wu, Hsu-Shui, Lin, Hui-Ting, Wang, Chi-Kuang Leo, Chiang, Yen-Feng, Chu, Hsueh-Ping, Hu, Meng-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenal Adrenal Glands - metabolism Animals Brain - metabolism Cholesterol Side-Chain Cleavage Enzyme - genetics Cre CYP11A1 diencephalon Female gonad hippocampus Humans Integrases - biosynthesis Integrases - genetics Male Mice Mice, Transgenic midbrain Ovary - metabolism Promoter Regions, Genetic Testis - metabolism VMHDM
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!