Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome
Background The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and visceral fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation...
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| Veröffentlicht in: | Circulation Journal 2006, Vol.70(11), pp.1437-1442 |
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| creator | Fujita, Koichi Nishizawa, Hitoshi Funahashi, Tohru Shimomura, Iichiro Shimabukuro, Michio |
| description | Background The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and visceral fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation and MetS. Methods and Results The study group consisted of Japanese men (n=44; 51.2±11.4 years) and women (n=61; 55.4 ±13.4 years). Urinary 8-epi-prostaglandin F2α (8-epi-PGF2 α) concentration, a biomarker of systemic oxidative stress, was significantly high in the subjects with MetS. As the urinary concentration of 8-epi-PGF2α increased, the number of criteria for MetS were significantly met (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Among parameters associated with MetS, the correlation coefficient of visceral fat area (VFA) with urinary 8-epi-PGF2α concentration was the highest (r=0.636, p |
| doi_str_mv | 10.1253/circj.70.1437 |
| format | Article |
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The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation and MetS. Methods and Results The study group consisted of Japanese men (n=44; 51.2±11.4 years) and women (n=61; 55.4 ±13.4 years). Urinary 8-epi-prostaglandin F2α (8-epi-PGF2 α) concentration, a biomarker of systemic oxidative stress, was significantly high in the subjects with MetS. As the urinary concentration of 8-epi-PGF2α increased, the number of criteria for MetS were significantly met (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Among parameters associated with MetS, the correlation coefficient of visceral fat area (VFA) with urinary 8-epi-PGF2α concentration was the highest (r=0.636, p<0.0001). In non-obese subjects, the correlation coefficient of VFA with urinary 8-epi-PGF2α concentration was higher (r=0.728, p<0.0001), although there was no significant correlation between subcutaneous fat area and urinary 8-epi-PGF2 α. Stepwise multiple regression analysis identified VFA as the strongest and independent determinant of urinary 8-epi-PGF2 α (p<0.0001) followed by adiponectin (p=0.0212) and, high sensitive C-reactive protein (p=0.0365). Conclusions Systemic oxidative stress, as measured by urinary 8-epi-PGF2α , is strongly associated with visceral fat accumulation and MetS. (Circ J 2006; 70: 1437 - 1442)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.70.1437</identifier><identifier>PMID: 17062967</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Adiponectin - blood ; Adult ; Aged ; C-Reactive Protein - analysis ; Cross-Sectional Studies ; Dinoprost - analogs & derivatives ; Dinoprost - blood ; Female ; Humans ; Intra-Abdominal Fat - physiopathology ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - physiopathology ; Middle Aged ; Oxidative Stress - physiology ; Reactive Oxygen Species - metabolism ; Regression Analysis ; Systemic oxidative stress ; Urinary 8-epi-PGF2α ; Visceral fat accumulation</subject><ispartof>Circulation Journal, 2006, Vol.70(11), pp.1437-1442</ispartof><rights>2006 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-259e356890ce7370f8e308a47993d5aff6fce6864660a5cacf2c9550cfa1b6043</citedby><cites>FETCH-LOGICAL-c481t-259e356890ce7370f8e308a47993d5aff6fce6864660a5cacf2c9550cfa1b6043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17062967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujita, Koichi</creatorcontrib><creatorcontrib>Nishizawa, Hitoshi</creatorcontrib><creatorcontrib>Funahashi, Tohru</creatorcontrib><creatorcontrib>Shimomura, Iichiro</creatorcontrib><creatorcontrib>Shimabukuro, Michio</creatorcontrib><title>Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and visceral fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation and MetS. Methods and Results The study group consisted of Japanese men (n=44; 51.2±11.4 years) and women (n=61; 55.4 ±13.4 years). Urinary 8-epi-prostaglandin F2α (8-epi-PGF2 α) concentration, a biomarker of systemic oxidative stress, was significantly high in the subjects with MetS. As the urinary concentration of 8-epi-PGF2α increased, the number of criteria for MetS were significantly met (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Among parameters associated with MetS, the correlation coefficient of visceral fat area (VFA) with urinary 8-epi-PGF2α concentration was the highest (r=0.636, p<0.0001). In non-obese subjects, the correlation coefficient of VFA with urinary 8-epi-PGF2α concentration was higher (r=0.728, p<0.0001), although there was no significant correlation between subcutaneous fat area and urinary 8-epi-PGF2 α. Stepwise multiple regression analysis identified VFA as the strongest and independent determinant of urinary 8-epi-PGF2 α (p<0.0001) followed by adiponectin (p=0.0212) and, high sensitive C-reactive protein (p=0.0365). Conclusions Systemic oxidative stress, as measured by urinary 8-epi-PGF2α , is strongly associated with visceral fat accumulation and MetS. (Circ J 2006; 70: 1437 - 1442)</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>C-Reactive Protein - analysis</subject><subject>Cross-Sectional Studies</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprost - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - physiopathology</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Middle Aged</subject><subject>Oxidative Stress - physiology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Regression Analysis</subject><subject>Systemic oxidative stress</subject><subject>Urinary 8-epi-PGF2α</subject><subject>Visceral fat accumulation</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkElPwzAQRi0EYj9yRT5xS7HjxMuxYpdAPZTlGE2dCXWVBWwH0X9Pugi4jOeTn5-sj5AzzkY8zcWldd4uRmpImVA75JCLTCWZTtnuepeJ0Zk4IEchLBhLDcvNPjngisnUSHVIYLoMERtn6eTblRDdF9Jp9BgCdYGOQ-isg4glfXNxTl9dsOihprcQ6djavunr4U3XUmhLGudInzDCrKsH33TZlr5r8ITsVVAHPN2ex-Tl9ub56j55nNw9XI0fE5tpHpM0NyhyqQ2zqIRilUbBNGTKGFHmUFWysii1zKRkkFuwVWpNnjNbAZ9JloljcrHxfvjus8cQi2b127qGFrs-FINaa8ZXYLIBre9C8FgVH9414JcFZ8Wq02LdaaGGNHQ68OdbcT9rsPyjtyUOwPUGWIQI7_gLgI_O1vhPx7dz5f27noMvsBU_zWSMGA</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Fujita, Koichi</creator><creator>Nishizawa, Hitoshi</creator><creator>Funahashi, Tohru</creator><creator>Shimomura, Iichiro</creator><creator>Shimabukuro, Michio</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome</title><author>Fujita, Koichi ; Nishizawa, Hitoshi ; Funahashi, Tohru ; Shimomura, Iichiro ; Shimabukuro, Michio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-259e356890ce7370f8e308a47993d5aff6fce6864660a5cacf2c9550cfa1b6043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Aged</topic><topic>C-Reactive Protein - analysis</topic><topic>Cross-Sectional Studies</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprost - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - physiopathology</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Middle Aged</topic><topic>Oxidative Stress - physiology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Regression Analysis</topic><topic>Systemic oxidative stress</topic><topic>Urinary 8-epi-PGF2α</topic><topic>Visceral fat accumulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujita, Koichi</creatorcontrib><creatorcontrib>Nishizawa, Hitoshi</creatorcontrib><creatorcontrib>Funahashi, Tohru</creatorcontrib><creatorcontrib>Shimomura, Iichiro</creatorcontrib><creatorcontrib>Shimabukuro, Michio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujita, Koichi</au><au>Nishizawa, Hitoshi</au><au>Funahashi, Tohru</au><au>Shimomura, Iichiro</au><au>Shimabukuro, Michio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2006</date><risdate>2006</risdate><volume>70</volume><issue>11</issue><spage>1437</spage><epage>1442</epage><pages>1437-1442</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and visceral fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation and MetS. Methods and Results The study group consisted of Japanese men (n=44; 51.2±11.4 years) and women (n=61; 55.4 ±13.4 years). Urinary 8-epi-prostaglandin F2α (8-epi-PGF2 α) concentration, a biomarker of systemic oxidative stress, was significantly high in the subjects with MetS. As the urinary concentration of 8-epi-PGF2α increased, the number of criteria for MetS were significantly met (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Among parameters associated with MetS, the correlation coefficient of visceral fat area (VFA) with urinary 8-epi-PGF2α concentration was the highest (r=0.636, p<0.0001). In non-obese subjects, the correlation coefficient of VFA with urinary 8-epi-PGF2α concentration was higher (r=0.728, p<0.0001), although there was no significant correlation between subcutaneous fat area and urinary 8-epi-PGF2 α. Stepwise multiple regression analysis identified VFA as the strongest and independent determinant of urinary 8-epi-PGF2 α (p<0.0001) followed by adiponectin (p=0.0212) and, high sensitive C-reactive protein (p=0.0365). Conclusions Systemic oxidative stress, as measured by urinary 8-epi-PGF2α , is strongly associated with visceral fat accumulation and MetS. (Circ J 2006; 70: 1437 - 1442)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>17062967</pmid><doi>10.1253/circj.70.1437</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin - blood Adult Aged C-Reactive Protein - analysis Cross-Sectional Studies Dinoprost - analogs & derivatives Dinoprost - blood Female Humans Intra-Abdominal Fat - physiopathology Male Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - physiopathology Middle Aged Oxidative Stress - physiology Reactive Oxygen Species - metabolism Regression Analysis Systemic oxidative stress Urinary 8-epi-PGF2α Visceral fat accumulation |
| title | Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome |
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