Prostatic Fatty Acids and Cancer Recurrence after Radical Prostatectomy for Early-Stage Prostate Cancer
Objective: Results from some observational studies suggest that diet and energy balance influence the clinical course of early-stage prostate cancer. To evaluate possible mechanisms, we prospectively examined the relation between prostatic concentrations of fatty acids at diagnosis and cancer recurr...
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| Veröffentlicht in: | Cancer causes & control 2007-03, Vol.18 (2), p.211-218 |
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| creator | Freeman, Vincent L. Flanigan, Robert C. Meydani, Mohsen |
| description | Objective: Results from some observational studies suggest that diet and energy balance influence the clinical course of early-stage prostate cancer. To evaluate possible mechanisms, we prospectively examined the relation between prostatic concentrations of fatty acids at diagnosis and cancer recurrence following primary therapy. Methods: Fatty acids were measured by capillary gas chromatography in fresh, non-cancerous prostate tissue collected from 184 men undergoing radical prostatectomy for clinically localized prostate cancer. Their association with risk of biochemical disease recurrence (a rising serum prostate-specific antigen following a disease-free [ |
| doi_str_mv | 10.1007/s10552-006-0095-6 |
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To evaluate possible mechanisms, we prospectively examined the relation between prostatic concentrations of fatty acids at diagnosis and cancer recurrence following primary therapy. Methods: Fatty acids were measured by capillary gas chromatography in fresh, non-cancerous prostate tissue collected from 184 men undergoing radical prostatectomy for clinically localized prostate cancer. Their association with risk of biochemical disease recurrence (a rising serum prostate-specific antigen following a disease-free [<0.1 ng/ml] interval ≥6 months) was analyzed using Cox proportional hazards models incorporating patient age, body mass index, tumor characteristics at diagnosis, and ethnicity. Results: During an average follow-up of 48.7 months (median = 47), 14 patients experienced biochemical recurrence. Percent total polyunsaturated fatty acid and the ratio of oleic-to-stearic acid associated with risk (multivariable hazards ratio [HR] = 0.51, 95% confidence interval [CI] = 0.29 to 0.90, p = 0.021 and HR = 1.68, 95% CI = 1.21 to 2.33, p = 0.002, respectively, per 1 standard deviation increase). Conclusions: The results of this study are preliminary, but they suggest that pre-diagnostic prostatic concentrations of fatty acids associate with risk of biochemical recurrence following radical prostatectomy for clinically localized prostate cancer.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-006-0095-6</identifier><identifier>PMID: 17216324</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Netherlands: Springer</publisher><subject>African Americans ; Aged ; Antigens ; Biochemistry ; Body Mass Index ; Chromatography ; Cohort Studies ; Diet ; Disease-Free Survival ; European Continental Ancestry Group ; Fatty acids ; Fatty Acids - analysis ; Humans ; Illinois - epidemiology ; Male ; Medical prognosis ; Middle Aged ; Monounsaturated fatty acids ; Neoplasm Recurrence, Local - chemistry ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Staging ; Nutrition research ; Obesity ; Pathology ; Patients ; Prognosis ; Proportional Hazards Models ; Prostate ; Prostate - chemistry ; Prostate cancer ; Prostate-Specific Antigen - blood ; Prostatectomy ; Prostatic Neoplasms - chemistry ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Risk ; Surgery ; Tumors ; Unsaturated fatty acids</subject><ispartof>Cancer causes & control, 2007-03, Vol.18 (2), p.211-218</ispartof><rights>Copyright 2007 Springer Science+Business Media B.V.</rights><rights>Springer Science+Business Media B.V. 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-3e55a10115dfce241100e292864efb7dcf88907ac1b11a0e0efe489f4282f0923</citedby><cites>FETCH-LOGICAL-c414t-3e55a10115dfce241100e292864efb7dcf88907ac1b11a0e0efe489f4282f0923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29736614$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29736614$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17216324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freeman, Vincent L.</creatorcontrib><creatorcontrib>Flanigan, Robert C.</creatorcontrib><creatorcontrib>Meydani, Mohsen</creatorcontrib><title>Prostatic Fatty Acids and Cancer Recurrence after Radical Prostatectomy for Early-Stage Prostate Cancer</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><description>Objective: Results from some observational studies suggest that diet and energy balance influence the clinical course of early-stage prostate cancer. To evaluate possible mechanisms, we prospectively examined the relation between prostatic concentrations of fatty acids at diagnosis and cancer recurrence following primary therapy. Methods: Fatty acids were measured by capillary gas chromatography in fresh, non-cancerous prostate tissue collected from 184 men undergoing radical prostatectomy for clinically localized prostate cancer. Their association with risk of biochemical disease recurrence (a rising serum prostate-specific antigen following a disease-free [<0.1 ng/ml] interval ≥6 months) was analyzed using Cox proportional hazards models incorporating patient age, body mass index, tumor characteristics at diagnosis, and ethnicity. Results: During an average follow-up of 48.7 months (median = 47), 14 patients experienced biochemical recurrence. Percent total polyunsaturated fatty acid and the ratio of oleic-to-stearic acid associated with risk (multivariable hazards ratio [HR] = 0.51, 95% confidence interval [CI] = 0.29 to 0.90, p = 0.021 and HR = 1.68, 95% CI = 1.21 to 2.33, p = 0.002, respectively, per 1 standard deviation increase). Conclusions: The results of this study are preliminary, but they suggest that pre-diagnostic prostatic concentrations of fatty acids associate with risk of biochemical recurrence following radical prostatectomy for clinically localized prostate cancer.</description><subject>African Americans</subject><subject>Aged</subject><subject>Antigens</subject><subject>Biochemistry</subject><subject>Body Mass Index</subject><subject>Chromatography</subject><subject>Cohort Studies</subject><subject>Diet</subject><subject>Disease-Free Survival</subject><subject>European Continental Ancestry Group</subject><subject>Fatty acids</subject><subject>Fatty Acids - analysis</subject><subject>Humans</subject><subject>Illinois - epidemiology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Monounsaturated fatty acids</subject><subject>Neoplasm Recurrence, Local - chemistry</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Staging</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Pathology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prostate</subject><subject>Prostate - chemistry</subject><subject>Prostate cancer</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - chemistry</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Risk</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Unsaturated fatty acids</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU9LJDEQxYOsrKO7H8DDLmEP3lpT-ds5yqCrICjqnkMmXZEeeqbdJH2Yb2-GaVzYQ0io-r1Hqh4h58AugTFzlYEpxRvGdD1WNfqILEAZ0RjO1ReyqDXTKC7FCTnNec0YU5qzr-QEDActuFyQt6c05uJLH-itL2VHr0PfZeq3HV36bcBEnzFMKWF9Ux_LvuC7PviBzkoMZdzsaBwTvfFp2DUvxb_hZ3e2-UaOox8yfp_vM_Ln9uZ1edc8PP6-X14_NEGCLI1ApTwwANXFgFxCnRO55a2WGFemC7FtLTM-wArAM2QYUbY2St7yyCwXZ-Ti4Puexr8T5uI2fQ44DH6L45Sdbm1rrBUV_PUfuB6ntK1_cxxEXZRVbYXgAIU6TU4Y3XvqNz7tHDC3j8AdInA1ArePwOmq-TkbT6sNdv8U884r8OMArHMZ02efWyO0Bik-AGwhip0</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Freeman, Vincent L.</creator><creator>Flanigan, Robert C.</creator><creator>Meydani, Mohsen</creator><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Prostatic Fatty Acids and Cancer Recurrence after Radical Prostatectomy for Early-Stage Prostate Cancer</title><author>Freeman, Vincent L. ; Flanigan, Robert C. ; Meydani, Mohsen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-3e55a10115dfce241100e292864efb7dcf88907ac1b11a0e0efe489f4282f0923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>African Americans</topic><topic>Aged</topic><topic>Antigens</topic><topic>Biochemistry</topic><topic>Body Mass Index</topic><topic>Chromatography</topic><topic>Cohort Studies</topic><topic>Diet</topic><topic>Disease-Free Survival</topic><topic>European Continental Ancestry Group</topic><topic>Fatty acids</topic><topic>Fatty Acids - analysis</topic><topic>Humans</topic><topic>Illinois - epidemiology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Monounsaturated fatty acids</topic><topic>Neoplasm Recurrence, Local - chemistry</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Staging</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Pathology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prostate</topic><topic>Prostate - chemistry</topic><topic>Prostate cancer</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - chemistry</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Risk</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Unsaturated fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freeman, Vincent L.</creatorcontrib><creatorcontrib>Flanigan, Robert C.</creatorcontrib><creatorcontrib>Meydani, Mohsen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freeman, Vincent L.</au><au>Flanigan, Robert C.</au><au>Meydani, Mohsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostatic Fatty Acids and Cancer Recurrence after Radical Prostatectomy for Early-Stage Prostate Cancer</atitle><jtitle>Cancer causes & control</jtitle><addtitle>Cancer Causes Control</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>18</volume><issue>2</issue><spage>211</spage><epage>218</epage><pages>211-218</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Objective: Results from some observational studies suggest that diet and energy balance influence the clinical course of early-stage prostate cancer. To evaluate possible mechanisms, we prospectively examined the relation between prostatic concentrations of fatty acids at diagnosis and cancer recurrence following primary therapy. Methods: Fatty acids were measured by capillary gas chromatography in fresh, non-cancerous prostate tissue collected from 184 men undergoing radical prostatectomy for clinically localized prostate cancer. Their association with risk of biochemical disease recurrence (a rising serum prostate-specific antigen following a disease-free [<0.1 ng/ml] interval ≥6 months) was analyzed using Cox proportional hazards models incorporating patient age, body mass index, tumor characteristics at diagnosis, and ethnicity. Results: During an average follow-up of 48.7 months (median = 47), 14 patients experienced biochemical recurrence. Percent total polyunsaturated fatty acid and the ratio of oleic-to-stearic acid associated with risk (multivariable hazards ratio [HR] = 0.51, 95% confidence interval [CI] = 0.29 to 0.90, p = 0.021 and HR = 1.68, 95% CI = 1.21 to 2.33, p = 0.002, respectively, per 1 standard deviation increase). Conclusions: The results of this study are preliminary, but they suggest that pre-diagnostic prostatic concentrations of fatty acids associate with risk of biochemical recurrence following radical prostatectomy for clinically localized prostate cancer.</abstract><cop>Netherlands</cop><pub>Springer</pub><pmid>17216324</pmid><doi>10.1007/s10552-006-0095-6</doi><tpages>8</tpages></addata></record> |
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| subjects | African Americans Aged Antigens Biochemistry Body Mass Index Chromatography Cohort Studies Diet Disease-Free Survival European Continental Ancestry Group Fatty acids Fatty Acids - analysis Humans Illinois - epidemiology Male Medical prognosis Middle Aged Monounsaturated fatty acids Neoplasm Recurrence, Local - chemistry Neoplasm Recurrence, Local - epidemiology Neoplasm Staging Nutrition research Obesity Pathology Patients Prognosis Proportional Hazards Models Prostate Prostate - chemistry Prostate cancer Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - chemistry Prostatic Neoplasms - epidemiology Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Risk Surgery Tumors Unsaturated fatty acids |
| title | Prostatic Fatty Acids and Cancer Recurrence after Radical Prostatectomy for Early-Stage Prostate Cancer |
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