Gelatinolytic activity in atherosclerotic plaques is highly localized and is associated with both macrophages and smooth muscle cells in vivo

Atherosclerosis is considered an inflammatory disease. Recent studies provided evidence for a predominant upstream location of plaque inflammation. The present study introduces a novel technique that evaluates the underlying mechanism of this spatial organization. In hypercholesterolemic rabbits, at...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2007-02, Vol.115 (5), p.609-616
Hauptverfasser:	SEGERS, Dolf, HELDERMAN, Frank, KRAMS, Rob, CHENG, Caroline, VAN DAMME, Luc C. A, TEMPEL, Dennie, BOERSMA, Eric, SERRUYS, Patrick W, DE CROM, Rini, VAN DER STEEN, Antonius F. W, HOLVOET, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - enzymology Aorta - pathology Atherosclerosis - enzymology Atherosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fundamental and applied biological sciences. Psychology Gelatin - metabolism Gelatinases - metabolism General aspects Macrophages - enzymology Macrophages - pathology Male Medical sciences Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Rabbits Vertebrates: cardiovascular system
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