Performance of Different Microsatellite Marker Panels for Detection of Mismatch Repair–Deficient Colorectal Tumors

Background Colorectal tumors caused by failure of the DNA mismatch repair system commonly show microsatellite instability. Our goals were to compare the performance of two panels of markers (a panel previously recommended by the National Cancer Institute [NCI] and a pentaplex of mononucleotide repea...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2007-02, Vol.99 (3), p.244-252
Hauptverfasser:	Xicola, Rosa M., Llor, Xavier, Pons, Elisenda, Castells, Antoni, Alenda, Cristina, Piñol, Virgínia, Andreu, Montserrat, Castellví-Bel, Sergi, Payá, Artemio, Jover, Rodrigo, Bessa, Xavier, Girós, Anna, Duque, José M., Nicolás-Pérez, David, Garcia, Ana M., Rigau, Joaquin, Gassull, Miquel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adenosine Triphosphatases - genetics Aged Biological and medical sciences Biomarkers, Tumor - genetics Carrier Proteins - genetics Cohort Studies Colorectal cancer Colorectal Neoplasms - genetics Comparative studies Deoxyribonucleic acid DNA DNA Mismatch Repair DNA Repair Enzymes - genetics DNA-Binding Proteins - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Genetic markers Humans Immunohistochemistry Male Medical sciences Microsatellite Instability Microsatellite Repeats Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutS Homolog 2 Protein - genetics Neoplasm Proteins - analysis Neoplasm Proteins - genetics Nuclear Proteins - genetics Polymerase Chain Reaction Predictive Value of Tests Proteins Sensitivity and Specificity Spain Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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