Chondrogenic Differentiation Alters the Immunosuppressive Property of Bone Marrow‐Derived Mesenchymal Stem Cells, and the Effect Is Partially due to the Upregulated Expression of B7 Molecules

To investigate the immunosuppressive properties of MSCs, in the present study we examined the immunogenicity of undifferentiated and trilineage‐differentiated (chondrocytes, osteoblasts, and adipocytes) rat bone marrow‐derived MSCs under xenogeneic conditions. After chondrogenic differentiation, rat...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2007-02, Vol.25 (2), p.364-370
Hauptverfasser:	Chen, Xi, McClurg, Angela, Zhou, Guang‐Qian, McCaigue, Mervyn, Armstrong, Marilyn Ann, Li, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - immunology B7-1 Antigen - genetics B7-1 Antigen - metabolism B7-2 Antigen - genetics B7-2 Antigen - metabolism Bone Marrow Cells - cytology Bone Marrow Cells - immunology CD83 Antigen Cell Differentiation Cell Lineage Cell Separation Chemotaxis Chondrogenesis Chondrogenic differentiation Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Humans Immune Tolerance - immunology Immunogenicity Immunoglobulins - immunology Lymphocytes - cytology Membrane Glycoproteins - immunology Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - immunology Phenotype Rats RNA, Messenger - genetics RNA, Messenger - metabolism Rosette Formation Up-Regulation
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