Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein
Abstract Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogat...
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| Veröffentlicht in: | Vaccine 2007-02, Vol.25 (10), p.1856-1867 |
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| creator | James, Cassandra M Abdad, Mohammad Y Mansfield, Josephine P Jacobsen, Hege K Vind, Azita Rezazadeh Stumbles, Philip A Bartlett, Emmalene J |
| description | Abstract Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replication in a vaccination/challenge mouse model. Differences in antiviral efficacy were found among the subtypes with IFNA5 and IFNA6 being most effective, while IFNA1 was the least effective in reducing lung virus replication. Mice vaccinated with combinatorial HA/IFNA6 or NP/IFNA6 showed reduced lung viral titres, clinical score, body weight loss, and pulmonary tissue damage compared to IFNA6, HA, or NP viral vaccination alone. In addition, IFNA6 increased IgG2a titres with upregulation of IFN-gamma response in the respiratory tract. We conclude that IFN-alpha 6 has antiviral and immunomodulatory effects, which improve efficacy of DNA vaccines for enhanced control of influenza. |
| doi_str_mv | 10.1016/j.vaccine.2006.10.038 |
| format | Article |
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DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replication in a vaccination/challenge mouse model. Differences in antiviral efficacy were found among the subtypes with IFNA5 and IFNA6 being most effective, while IFNA1 was the least effective in reducing lung virus replication. Mice vaccinated with combinatorial HA/IFNA6 or NP/IFNA6 showed reduced lung viral titres, clinical score, body weight loss, and pulmonary tissue damage compared to IFNA6, HA, or NP viral vaccination alone. In addition, IFNA6 increased IgG2a titres with upregulation of IFN-gamma response in the respiratory tract. We conclude that IFN-alpha 6 has antiviral and immunomodulatory effects, which improve efficacy of DNA vaccines for enhanced control of influenza.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2006.10.038</identifier><identifier>PMID: 17240000</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Animals ; Antibodies, Viral - blood ; Body Weight ; Cytokines ; Cytomegalovirus ; Deoxyribonucleic acid ; Disease Models, Animal ; DNA ; DNA vaccines ; Hemagglutinin Glycoproteins, Influenza Virus - genetics ; Hemagglutinin Glycoproteins, Influenza Virus - immunology ; Humans ; Immune system ; Immunoglobulin G - blood ; Influenza ; Influenza A Virus, H1N1 Subtype - genetics ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza A Virus, H1N1 Subtype - physiology ; Influenza Vaccines - genetics ; Influenza Vaccines - immunology ; Influenza virus ; Influenza, Human - prevention & control ; Interferon-alpha - classification ; Interferon-alpha - genetics ; Interferon-alpha - immunology ; Interferon-gamma - biosynthesis ; Lung - pathology ; Lung - virology ; Male ; Mice ; Mice, Inbred BALB C ; Nucleoproteins - genetics ; Nucleoproteins - immunology ; Orthomyxoviridae Infections - prevention & control ; Pandemics ; Respiratory tract ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - immunology ; Rodents ; Type I interferons ; Vaccines ; Vaccines, DNA - genetics ; Vaccines, DNA - immunology ; Viral Core Proteins - genetics ; Viral Core Proteins - immunology</subject><ispartof>Vaccine, 2007-02, Vol.25 (10), p.1856-1867</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><rights>Copyright Elsevier Limited Feb 26, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-d6faab1e645b5b2d0b8f51aa943bbe769fcab5256a99727dd542bb3c3bcf40a93</citedby><cites>FETCH-LOGICAL-c477t-d6faab1e645b5b2d0b8f51aa943bbe769fcab5256a99727dd542bb3c3bcf40a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1547165166?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004,64394,64396,64398,72478</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17240000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>James, Cassandra M</creatorcontrib><creatorcontrib>Abdad, Mohammad Y</creatorcontrib><creatorcontrib>Mansfield, Josephine P</creatorcontrib><creatorcontrib>Jacobsen, Hege K</creatorcontrib><creatorcontrib>Vind, Azita Rezazadeh</creatorcontrib><creatorcontrib>Stumbles, Philip A</creatorcontrib><creatorcontrib>Bartlett, Emmalene J</creatorcontrib><title>Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replication in a vaccination/challenge mouse model. Differences in antiviral efficacy were found among the subtypes with IFNA5 and IFNA6 being most effective, while IFNA1 was the least effective in reducing lung virus replication. Mice vaccinated with combinatorial HA/IFNA6 or NP/IFNA6 showed reduced lung viral titres, clinical score, body weight loss, and pulmonary tissue damage compared to IFNA6, HA, or NP viral vaccination alone. In addition, IFNA6 increased IgG2a titres with upregulation of IFN-gamma response in the respiratory tract. We conclude that IFN-alpha 6 has antiviral and immunomodulatory effects, which improve efficacy of DNA vaccines for enhanced control of influenza.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Body Weight</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>Deoxyribonucleic acid</subject><subject>Disease Models, Animal</subject><subject>DNA</subject><subject>DNA vaccines</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus - genetics</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus - immunology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunoglobulin G - blood</subject><subject>Influenza</subject><subject>Influenza A Virus, H1N1 Subtype - genetics</subject><subject>Influenza A Virus, H1N1 Subtype - immunology</subject><subject>Influenza A Virus, H1N1 Subtype - physiology</subject><subject>Influenza Vaccines - genetics</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza virus</subject><subject>Influenza, Human - prevention & control</subject><subject>Interferon-alpha - classification</subject><subject>Interferon-alpha - genetics</subject><subject>Interferon-alpha - immunology</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Lung - pathology</subject><subject>Lung - virology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nucleoproteins - genetics</subject><subject>Nucleoproteins - immunology</subject><subject>Orthomyxoviridae Infections - prevention & control</subject><subject>Pandemics</subject><subject>Respiratory tract</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - immunology</subject><subject>Rodents</subject><subject>Type I interferons</subject><subject>Vaccines</subject><subject>Vaccines, DNA - genetics</subject><subject>Vaccines, DNA - immunology</subject><subject>Viral Core Proteins - genetics</subject><subject>Viral Core Proteins - 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>James, Cassandra M</au><au>Abdad, Mohammad Y</au><au>Mansfield, Josephine P</au><au>Jacobsen, Hege K</au><au>Vind, Azita Rezazadeh</au><au>Stumbles, Philip A</au><au>Bartlett, Emmalene J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2007-02-26</date><risdate>2007</risdate><volume>25</volume><issue>10</issue><spage>1856</spage><epage>1867</epage><pages>1856-1867</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Abstract Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replication in a vaccination/challenge mouse model. Differences in antiviral efficacy were found among the subtypes with IFNA5 and IFNA6 being most effective, while IFNA1 was the least effective in reducing lung virus replication. Mice vaccinated with combinatorial HA/IFNA6 or NP/IFNA6 showed reduced lung viral titres, clinical score, body weight loss, and pulmonary tissue damage compared to IFNA6, HA, or NP viral vaccination alone. In addition, IFNA6 increased IgG2a titres with upregulation of IFN-gamma response in the respiratory tract. We conclude that IFN-alpha 6 has antiviral and immunomodulatory effects, which improve efficacy of DNA vaccines for enhanced control of influenza.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>17240000</pmid><doi>10.1016/j.vaccine.2006.10.038</doi><tpages>12</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Antibodies, Viral - blood Body Weight Cytokines Cytomegalovirus Deoxyribonucleic acid Disease Models, Animal DNA DNA vaccines Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Immune system Immunoglobulin G - blood Influenza Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - physiology Influenza Vaccines - genetics Influenza Vaccines - immunology Influenza virus Influenza, Human - prevention & control Interferon-alpha - classification Interferon-alpha - genetics Interferon-alpha - immunology Interferon-gamma - biosynthesis Lung - pathology Lung - virology Male Mice Mice, Inbred BALB C Nucleoproteins - genetics Nucleoproteins - immunology Orthomyxoviridae Infections - prevention & control Pandemics Respiratory tract RNA-Binding Proteins - genetics RNA-Binding Proteins - immunology Rodents Type I interferons Vaccines Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Core Proteins - genetics Viral Core Proteins - immunology |
| title | Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein |
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