Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins

Fetuin-A is a known inhibitor of vascular calcification in vitro. In arteries with calcification, there is increased immunostaining for fetuin-A. However, vascular smooth muscle cells (VSMC) do not synthesize fetuin-A, suggesting fetuin-A may be endocytosed to exert its inhibitory effects. To examin...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2007-02, Vol.292 (2), p.F599-F606
Hauptverfasser:	Chen, Neal X, O'Neill, Kalisha D, Chen, Xianming, Duan, Danxia, Wang, Exing, Sturek, Michael S, Edwards, Jason M, Moe, Sharon M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - metabolism Animals Annexins - physiology Biochemistry Calcium Calcium - physiology Calcium Channels - drug effects Cattle Cells Cells, Cultured Endocytosis Ionomycin - pharmacology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Proteins Thiazepines - pharmacology Veins & arteries
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