Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes

OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes. METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic...

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Veröffentlicht in:Journal of hypertension 2007-03, Vol.25 (3), p.565-570
Hauptverfasser: van Rijn, Marie Josee E, Schut, Anna FC, Aulchenko, Yurii S, Deinum, Jaap, Sayed-Tabatabaei, Fakhredin A, Yazdanpanah, Mojgan, Isaacs, Aaron, Axenovich, Tatiana I, Zorkoltseva, Irina V, Zillikens, M Carola, Pols, Huib AP, Witteman, Jacqueline CM, Oostra, Ben A, van Duijn, Cornelia M
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container_end_page 570
container_issue 3
container_start_page 565
container_title Journal of hypertension
container_volume 25
creator van Rijn, Marie Josee E
Schut, Anna FC
Aulchenko, Yurii S
Deinum, Jaap
Sayed-Tabatabaei, Fakhredin A
Yazdanpanah, Mojgan
Isaacs, Aaron
Axenovich, Tatiana I
Zorkoltseva, Irina V
Zillikens, M Carola
Pols, Huib AP
Witteman, Jacqueline CM
Oostra, Ben A
van Duijn, Cornelia M
description OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes. METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed. RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06). CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. As new genes associated with blood pressure are localized in the future, their effect on blood pressure variance should be calculated.
doi_str_mv 10.1097/HJH.0b013e32801449fb
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METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed. RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06). CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. As new genes associated with blood pressure are localized in the future, their effect on blood pressure variance should be calculated.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/HJH.0b013e32801449fb</identifier><identifier>PMID: 17278972</identifier><language>eng</language><publisher>England: Lippincott Williams &amp; Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Angiotensinogen - genetics ; Blood Pressure - genetics ; Cohort Studies ; Female ; Genetic Testing ; Heterotrimeric GTP-Binding Proteins - genetics ; Humans ; Hypertension - genetics ; Inheritance Patterns ; Male ; Middle Aged ; Multifactorial Inheritance - genetics ; Netherlands - ethnology ; Pedigree ; Polymorphism, Single Nucleotide ; Receptor, Angiotensin, Type 1 - genetics ; Sterol Regulatory Element Binding Protein 1 - genetics</subject><ispartof>Journal of hypertension, 2007-03, Vol.25 (3), p.565-570</ispartof><rights>2007 Lippincott Williams &amp; Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3503-e4b0420b8ef9575f66580aedc2f912c46554d91f615914bcf7a5ce73e23d2e853</citedby><cites>FETCH-LOGICAL-c3503-e4b0420b8ef9575f66580aedc2f912c46554d91f615914bcf7a5ce73e23d2e853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17278972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Rijn, Marie Josee E</creatorcontrib><creatorcontrib>Schut, Anna FC</creatorcontrib><creatorcontrib>Aulchenko, Yurii S</creatorcontrib><creatorcontrib>Deinum, Jaap</creatorcontrib><creatorcontrib>Sayed-Tabatabaei, Fakhredin A</creatorcontrib><creatorcontrib>Yazdanpanah, Mojgan</creatorcontrib><creatorcontrib>Isaacs, Aaron</creatorcontrib><creatorcontrib>Axenovich, Tatiana I</creatorcontrib><creatorcontrib>Zorkoltseva, Irina V</creatorcontrib><creatorcontrib>Zillikens, M Carola</creatorcontrib><creatorcontrib>Pols, Huib AP</creatorcontrib><creatorcontrib>Witteman, Jacqueline CM</creatorcontrib><creatorcontrib>Oostra, Ben A</creatorcontrib><creatorcontrib>van Duijn, Cornelia M</creatorcontrib><title>Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes. METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed. RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06). CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. 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METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed. RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06). CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. As new genes associated with blood pressure are localized in the future, their effect on blood pressure variance should be calculated.</abstract><cop>England</cop><pub>Lippincott Williams &amp; Wilkins, Inc</pub><pmid>17278972</pmid><doi>10.1097/HJH.0b013e32801449fb</doi><tpages>6</tpages></addata></record>
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source MEDLINE; Journals@Ovid Complete
subjects Adolescent
Adult
Aged
Aged, 80 and over
Angiotensinogen - genetics
Blood Pressure - genetics
Cohort Studies
Female
Genetic Testing
Heterotrimeric GTP-Binding Proteins - genetics
Humans
Hypertension - genetics
Inheritance Patterns
Male
Middle Aged
Multifactorial Inheritance - genetics
Netherlands - ethnology
Pedigree
Polymorphism, Single Nucleotide
Receptor, Angiotensin, Type 1 - genetics
Sterol Regulatory Element Binding Protein 1 - genetics
title Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes
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