Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes
OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes. METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic...
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Veröffentlicht in: | Journal of hypertension 2007-03, Vol.25 (3), p.565-570 |
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creator | van Rijn, Marie Josee E Schut, Anna FC Aulchenko, Yurii S Deinum, Jaap Sayed-Tabatabaei, Fakhredin A Yazdanpanah, Mojgan Isaacs, Aaron Axenovich, Tatiana I Zorkoltseva, Irina V Zillikens, M Carola Pols, Huib AP Witteman, Jacqueline CM Oostra, Ben A van Duijn, Cornelia M |
description | OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes.
METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed.
RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06).
CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. As new genes associated with blood pressure are localized in the future, their effect on blood pressure variance should be calculated. |
doi_str_mv | 10.1097/HJH.0b013e32801449fb |
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METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed.
RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06).
CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. As new genes associated with blood pressure are localized in the future, their effect on blood pressure variance should be calculated.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/HJH.0b013e32801449fb</identifier><identifier>PMID: 17278972</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Angiotensinogen - genetics ; Blood Pressure - genetics ; Cohort Studies ; Female ; Genetic Testing ; Heterotrimeric GTP-Binding Proteins - genetics ; Humans ; Hypertension - genetics ; Inheritance Patterns ; Male ; Middle Aged ; Multifactorial Inheritance - genetics ; Netherlands - ethnology ; Pedigree ; Polymorphism, Single Nucleotide ; Receptor, Angiotensin, Type 1 - genetics ; Sterol Regulatory Element Binding Protein 1 - genetics</subject><ispartof>Journal of hypertension, 2007-03, Vol.25 (3), p.565-570</ispartof><rights>2007 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3503-e4b0420b8ef9575f66580aedc2f912c46554d91f615914bcf7a5ce73e23d2e853</citedby><cites>FETCH-LOGICAL-c3503-e4b0420b8ef9575f66580aedc2f912c46554d91f615914bcf7a5ce73e23d2e853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17278972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Rijn, Marie Josee E</creatorcontrib><creatorcontrib>Schut, Anna FC</creatorcontrib><creatorcontrib>Aulchenko, Yurii S</creatorcontrib><creatorcontrib>Deinum, Jaap</creatorcontrib><creatorcontrib>Sayed-Tabatabaei, Fakhredin A</creatorcontrib><creatorcontrib>Yazdanpanah, Mojgan</creatorcontrib><creatorcontrib>Isaacs, Aaron</creatorcontrib><creatorcontrib>Axenovich, Tatiana I</creatorcontrib><creatorcontrib>Zorkoltseva, Irina V</creatorcontrib><creatorcontrib>Zillikens, M Carola</creatorcontrib><creatorcontrib>Pols, Huib AP</creatorcontrib><creatorcontrib>Witteman, Jacqueline CM</creatorcontrib><creatorcontrib>Oostra, Ben A</creatorcontrib><creatorcontrib>van Duijn, Cornelia M</creatorcontrib><title>Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes.
METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed.
RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06).
CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. As new genes associated with blood pressure are localized in the future, their effect on blood pressure variance should be calculated.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiotensinogen - genetics</subject><subject>Blood Pressure - genetics</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Genetic Testing</subject><subject>Heterotrimeric GTP-Binding Proteins - genetics</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Inheritance Patterns</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multifactorial Inheritance - genetics</subject><subject>Netherlands - ethnology</subject><subject>Pedigree</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptor, Angiotensin, Type 1 - genetics</subject><subject>Sterol Regulatory Element Binding Protein 1 - genetics</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1uFDEQhS0EIkPgBgh5xc7Bv-32EkWEAUViA2vLdpcZg6c92G7C3IFD09EMipRFqapU771FfQi9ZvSKUaPfbT9vr6inTIDgI2VSmuifoA2TWhClzPgUbSgfBBmE4hfoRWs_KKWj0eI5umCa63XkG_R3CzV151NO_YhLxD6XMuFDhdaWCrhXl3rDbp5w3wH-DjP0FHAoc6_JLz2VGffy2PXb1eTmABj-HLJLM0zYH3EsSz0pyX8lqZBdX8_3we0lehZdbvDq3C_Rt5sPX6-35PbLx0_X729JEIoKAtJTyakfIRqlVRwGNVIHU-DRMB7koJScDIsDU4ZJH6J2KoAWwMXEYVTiEr095R5q-bVA63afWoCc3QxlaXYYzaiY0qtQnoShltYqRHuoae_q0TJq7ynYlYJ9TGG1vTnnL34P04Pp_PaH3LuSO9T2My93UO0OXO47u3KictSccEo1FetG1mJC_APHmJcj</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>van Rijn, Marie Josee E</creator><creator>Schut, Anna FC</creator><creator>Aulchenko, Yurii S</creator><creator>Deinum, Jaap</creator><creator>Sayed-Tabatabaei, Fakhredin A</creator><creator>Yazdanpanah, Mojgan</creator><creator>Isaacs, Aaron</creator><creator>Axenovich, Tatiana I</creator><creator>Zorkoltseva, Irina V</creator><creator>Zillikens, M Carola</creator><creator>Pols, Huib AP</creator><creator>Witteman, Jacqueline CM</creator><creator>Oostra, Ben A</creator><creator>van Duijn, Cornelia M</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes</title><author>van Rijn, Marie Josee E ; Schut, Anna FC ; Aulchenko, Yurii S ; Deinum, Jaap ; Sayed-Tabatabaei, Fakhredin A ; Yazdanpanah, Mojgan ; Isaacs, Aaron ; Axenovich, Tatiana I ; Zorkoltseva, Irina V ; Zillikens, M Carola ; Pols, Huib AP ; Witteman, Jacqueline CM ; Oostra, Ben A ; van Duijn, Cornelia M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3503-e4b0420b8ef9575f66580aedc2f912c46554d91f615914bcf7a5ce73e23d2e853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiotensinogen - genetics</topic><topic>Blood Pressure - genetics</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Genetic Testing</topic><topic>Heterotrimeric GTP-Binding Proteins - genetics</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Inheritance Patterns</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multifactorial Inheritance - genetics</topic><topic>Netherlands - ethnology</topic><topic>Pedigree</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptor, Angiotensin, Type 1 - genetics</topic><topic>Sterol Regulatory Element Binding Protein 1 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Rijn, Marie Josee E</creatorcontrib><creatorcontrib>Schut, Anna FC</creatorcontrib><creatorcontrib>Aulchenko, Yurii S</creatorcontrib><creatorcontrib>Deinum, Jaap</creatorcontrib><creatorcontrib>Sayed-Tabatabaei, Fakhredin A</creatorcontrib><creatorcontrib>Yazdanpanah, Mojgan</creatorcontrib><creatorcontrib>Isaacs, Aaron</creatorcontrib><creatorcontrib>Axenovich, Tatiana I</creatorcontrib><creatorcontrib>Zorkoltseva, Irina V</creatorcontrib><creatorcontrib>Zillikens, M Carola</creatorcontrib><creatorcontrib>Pols, Huib AP</creatorcontrib><creatorcontrib>Witteman, Jacqueline CM</creatorcontrib><creatorcontrib>Oostra, Ben A</creatorcontrib><creatorcontrib>van Duijn, Cornelia M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Rijn, Marie Josee E</au><au>Schut, Anna FC</au><au>Aulchenko, Yurii S</au><au>Deinum, Jaap</au><au>Sayed-Tabatabaei, Fakhredin A</au><au>Yazdanpanah, Mojgan</au><au>Isaacs, Aaron</au><au>Axenovich, Tatiana I</au><au>Zorkoltseva, Irina V</au><au>Zillikens, M Carola</au><au>Pols, Huib AP</au><au>Witteman, Jacqueline CM</au><au>Oostra, Ben A</au><au>van Duijn, Cornelia M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>2007-03</date><risdate>2007</risdate><volume>25</volume><issue>3</issue><spage>565</spage><epage>570</epage><pages>565-570</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><abstract>OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes.
METHODSAll participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a variance components approach (SOLAR). Polymorphisms of the α-adducin (ADD1), angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and G protein β3 (GNB3) genes were typed.
RESULTSHeritability estimates were significant for all four blood pressure traits, ranging between 0.24 and 0.37. Genetic correlations between systolic blood pressure, diastolic blood pressure and mean arterial pressure were high (0.93–0.98), and those between pulse pressure and diastolic blood pressure were low (0.05). The ADD1 polymorphism explained 0.3% of the variance of pulse pressure (P = 0.07), and the polymorphism of GNB3 explained 0.4% of the variance of systolic blood pressure (P = 0.02), 0.2% of mean arterial pressure (P = 0.05) and 0.3% of pulse pressure (P = 0.06).
CONCLUSIONGenetic factors contribute to a substantial proportion of blood pressure variance. In this study, the effect of polymorphisms of ADD1, AGT, AT1R and GNB3 explained a very small proportion of the heritability of blood pressure traits. As new genes associated with blood pressure are localized in the future, their effect on blood pressure variance should be calculated.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>17278972</pmid><doi>10.1097/HJH.0b013e32801449fb</doi><tpages>6</tpages></addata></record> |
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subjects | Adolescent Adult Aged Aged, 80 and over Angiotensinogen - genetics Blood Pressure - genetics Cohort Studies Female Genetic Testing Heterotrimeric GTP-Binding Proteins - genetics Humans Hypertension - genetics Inheritance Patterns Male Middle Aged Multifactorial Inheritance - genetics Netherlands - ethnology Pedigree Polymorphism, Single Nucleotide Receptor, Angiotensin, Type 1 - genetics Sterol Regulatory Element Binding Protein 1 - genetics |
title | Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes |
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