Scintigraphic imaging of P-glycoprotein expression with a radiolabelled antibody

P-glycoprotein (P-gp) is a membrane efflux pump protein that is involved in multidrug resistance (MDR). Tumour cells with high P-gp expression show poor response to cancer treatment with several chemotherapeutics. In vivo targeting and visualisation of P-gp expression would allow MDR to be evaluated...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2006-11, Vol.33 (11), p.1266-1272
Hauptverfasser:	van Eerd, Julliëtte E M, de Geus-Oei, Lioe-Fee, Oyen, Wim J G, Corstens, Frans H M, Boerman, Otto C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacokinetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Drug resistance Feasibility Studies Female Gene expression Gene Expression Profiling - methods Glycoproteins Indium Radioisotopes - pharmacokinetics Medical imaging Mice Mice, Inbred BALB C Mice, Nude Monoclonal antibodies Nuclear medicine Radioactivity Radionuclide Imaging Reproducibility of Results Rodents Sensitivity and Specificity Tissue Distribution Uterine Neoplasms - diagnostic imaging Uterine Neoplasms - metabolism
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