Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort
OBJECTIVEExperimental evidence indicates that maternal undernutrition during gestation may program hypertension in the offspring. We investigated whether maternal undernutrition leads to increased arterial stiffness. METHODSWe measured carotid artery lumen diameter (LD), distensibility (DC), stiffne...
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| Veröffentlicht in: | Journal of hypertension 2007-03, Vol.25 (3), p.533-540 |
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| creator | Painter, Rebecca C de Rooij, Susanne R Bossuyt, Patrick M de Groot, Eric Stok, Wim J Osmond, Clive Barker, David J Bleker, Otto P Roseboom, Tessa J |
| description | OBJECTIVEExperimental evidence indicates that maternal undernutrition during gestation may program hypertension in the offspring. We investigated whether maternal undernutrition leads to increased arterial stiffness.
METHODSWe measured carotid artery lumen diameter (LD), distensibility (DC), stiffness (β), and compliance (CC) by M-mode ultrasound in 673 individuals, aged 56–61 years, who had been born as term singletons around the time of the 1944–45 Dutch famine.
RESULTSMaternal famine exposure had no effect on any of the measures of carotid size or stiffness in the offspring. Low maternal weight at the end of pregnancy and low birth weight were associated with decreased LD (0.01 mm/kg maternal weight, sex-adjusted P < 0.001; 0.1 mm/kg birth weight, sex-adjusted P = 0.08) and CC (0.002 mm/kPa per kg maternal weight, sex-adjusted P = 0.001; 0.03 mm/kPa per kg birth weight, sex-adjusted P = 0.03), but neither was associated with increased β, or decreased DC. These effects were not attenuated by adjusting for maternal protein/carbohydrate ratio in the third trimester. The association of low birth weight with increased CC diminished after adjusting for maternal weight. The association of maternal weight with CC was smaller when adjusted for LD.
CONCLUSIONOur findings suggest that small maternal size, not poor maternal diet, in late gestation programs decreased arterial compliance in the adult offspring by affecting vessel size rather than vessel wall stiffness. |
| doi_str_mv | 10.1097/HJH.0b013e328012135b |
| format | Article |
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METHODSWe measured carotid artery lumen diameter (LD), distensibility (DC), stiffness (β), and compliance (CC) by M-mode ultrasound in 673 individuals, aged 56–61 years, who had been born as term singletons around the time of the 1944–45 Dutch famine.
RESULTSMaternal famine exposure had no effect on any of the measures of carotid size or stiffness in the offspring. Low maternal weight at the end of pregnancy and low birth weight were associated with decreased LD (0.01 mm/kg maternal weight, sex-adjusted P < 0.001; 0.1 mm/kg birth weight, sex-adjusted P = 0.08) and CC (0.002 mm/kPa per kg maternal weight, sex-adjusted P = 0.001; 0.03 mm/kPa per kg birth weight, sex-adjusted P = 0.03), but neither was associated with increased β, or decreased DC. These effects were not attenuated by adjusting for maternal protein/carbohydrate ratio in the third trimester. The association of low birth weight with increased CC diminished after adjusting for maternal weight. The association of maternal weight with CC was smaller when adjusted for LD.
CONCLUSIONOur findings suggest that small maternal size, not poor maternal diet, in late gestation programs decreased arterial compliance in the adult offspring by affecting vessel size rather than vessel wall stiffness.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/HJH.0b013e328012135b</identifier><identifier>PMID: 17278968</identifier><identifier>CODEN: JOHYD3</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Arteries - physiology ; Carotid Arteries - ultrastructure ; Cohort Studies ; Diabetes. Impaired glucose tolerance ; Elasticity ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypertension - etiology ; Infant, Low Birth Weight - physiology ; Infant, Newborn ; Male ; Malnutrition - complications ; Medical sciences ; Middle Aged ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal Nutritional Physiological Phenomena ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Journal of hypertension, 2007-03, Vol.25 (3), p.533-540</ispartof><rights>2007 Lippincott Williams & Wilkins, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4469-7f0996cdbdbbee594a6e2a97758b08ab41b821dbfe7866dbeaef7a92040dfa5a3</citedby><cites>FETCH-LOGICAL-c4469-7f0996cdbdbbee594a6e2a97758b08ab41b821dbfe7866dbeaef7a92040dfa5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18483381$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17278968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Painter, Rebecca C</creatorcontrib><creatorcontrib>de Rooij, Susanne R</creatorcontrib><creatorcontrib>Bossuyt, Patrick M</creatorcontrib><creatorcontrib>de Groot, Eric</creatorcontrib><creatorcontrib>Stok, Wim J</creatorcontrib><creatorcontrib>Osmond, Clive</creatorcontrib><creatorcontrib>Barker, David J</creatorcontrib><creatorcontrib>Bleker, Otto P</creatorcontrib><creatorcontrib>Roseboom, Tessa J</creatorcontrib><title>Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>OBJECTIVEExperimental evidence indicates that maternal undernutrition during gestation may program hypertension in the offspring. We investigated whether maternal undernutrition leads to increased arterial stiffness.
METHODSWe measured carotid artery lumen diameter (LD), distensibility (DC), stiffness (β), and compliance (CC) by M-mode ultrasound in 673 individuals, aged 56–61 years, who had been born as term singletons around the time of the 1944–45 Dutch famine.
RESULTSMaternal famine exposure had no effect on any of the measures of carotid size or stiffness in the offspring. Low maternal weight at the end of pregnancy and low birth weight were associated with decreased LD (0.01 mm/kg maternal weight, sex-adjusted P < 0.001; 0.1 mm/kg birth weight, sex-adjusted P = 0.08) and CC (0.002 mm/kPa per kg maternal weight, sex-adjusted P = 0.001; 0.03 mm/kPa per kg birth weight, sex-adjusted P = 0.03), but neither was associated with increased β, or decreased DC. These effects were not attenuated by adjusting for maternal protein/carbohydrate ratio in the third trimester. The association of low birth weight with increased CC diminished after adjusting for maternal weight. The association of maternal weight with CC was smaller when adjusted for LD.
CONCLUSIONOur findings suggest that small maternal size, not poor maternal diet, in late gestation programs decreased arterial compliance in the adult offspring by affecting vessel size rather than vessel wall stiffness.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - physiology</subject><subject>Carotid Arteries - ultrastructure</subject><subject>Cohort Studies</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Elasticity</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypertension - etiology</subject><subject>Infant, Low Birth Weight - physiology</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Malnutrition - complications</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal Nutritional Physiological Phenomena</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1DAUhS0EokPhDRDyBnYp_ot_2KEWOkVFbGAdXcd2Y_Akg-2o6tvjaUcaiZXlq-8c635G6C0lF5QY9XH7bXtBLKHcc6YJZZT39hnaUKF41_dGP0cbwiTvJO_ZGXpVym9CiDaKv0RnVDGljdQb9PAdqs8zJDyvNccalxm7Ncf5Dt_5UuFxALPDI-SlRochNz42flx2-xRhHj2OM66Tx-DWVPESQtkfCj49Dq_WOk44wC7OHtuY69SS05Lra_QiQCr-zfE8R7--fvl5ue1uf1zfXH6-7UYhpOlUIMbI0Vlnrfe9ESA9A6NUry3RYAW1mlFng1daSmc9-KDAMCKIC9ADP0cfnnr3efm7tp2GXSyjTwlmv6xlkNpoIXvWQPEEjnkpJfswtDV2kB8GSoaD8qEpH_5X3mLvjv2r3Xl3Ch0dN-D9EYAyQgq5OYvlxGmhOdf09P79kprj8iet9z4Pk4dUp6F9HhFasY4Roghvt-4wMvwfyPOdIg</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Painter, Rebecca C</creator><creator>de Rooij, Susanne R</creator><creator>Bossuyt, Patrick M</creator><creator>de Groot, Eric</creator><creator>Stok, Wim J</creator><creator>Osmond, Clive</creator><creator>Barker, David J</creator><creator>Bleker, Otto P</creator><creator>Roseboom, Tessa J</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort</title><author>Painter, Rebecca C ; de Rooij, Susanne R ; Bossuyt, Patrick M ; de Groot, Eric ; Stok, Wim J ; Osmond, Clive ; Barker, David J ; Bleker, Otto P ; Roseboom, Tessa J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4469-7f0996cdbdbbee594a6e2a97758b08ab41b821dbfe7866dbeaef7a92040dfa5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - physiology</topic><topic>Carotid Arteries - ultrastructure</topic><topic>Cohort Studies</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Elasticity</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypertension - etiology</topic><topic>Infant, Low Birth Weight - physiology</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Malnutrition - complications</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal Nutritional Physiological Phenomena</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Painter, Rebecca C</creatorcontrib><creatorcontrib>de Rooij, Susanne R</creatorcontrib><creatorcontrib>Bossuyt, Patrick M</creatorcontrib><creatorcontrib>de Groot, Eric</creatorcontrib><creatorcontrib>Stok, Wim J</creatorcontrib><creatorcontrib>Osmond, Clive</creatorcontrib><creatorcontrib>Barker, David J</creatorcontrib><creatorcontrib>Bleker, Otto P</creatorcontrib><creatorcontrib>Roseboom, Tessa J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Painter, Rebecca C</au><au>de Rooij, Susanne R</au><au>Bossuyt, Patrick M</au><au>de Groot, Eric</au><au>Stok, Wim J</au><au>Osmond, Clive</au><au>Barker, David J</au><au>Bleker, Otto P</au><au>Roseboom, Tessa J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>2007-03</date><risdate>2007</risdate><volume>25</volume><issue>3</issue><spage>533</spage><epage>540</epage><pages>533-540</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><coden>JOHYD3</coden><abstract>OBJECTIVEExperimental evidence indicates that maternal undernutrition during gestation may program hypertension in the offspring. We investigated whether maternal undernutrition leads to increased arterial stiffness.
METHODSWe measured carotid artery lumen diameter (LD), distensibility (DC), stiffness (β), and compliance (CC) by M-mode ultrasound in 673 individuals, aged 56–61 years, who had been born as term singletons around the time of the 1944–45 Dutch famine.
RESULTSMaternal famine exposure had no effect on any of the measures of carotid size or stiffness in the offspring. Low maternal weight at the end of pregnancy and low birth weight were associated with decreased LD (0.01 mm/kg maternal weight, sex-adjusted P < 0.001; 0.1 mm/kg birth weight, sex-adjusted P = 0.08) and CC (0.002 mm/kPa per kg maternal weight, sex-adjusted P = 0.001; 0.03 mm/kPa per kg birth weight, sex-adjusted P = 0.03), but neither was associated with increased β, or decreased DC. These effects were not attenuated by adjusting for maternal protein/carbohydrate ratio in the third trimester. The association of low birth weight with increased CC diminished after adjusting for maternal weight. The association of maternal weight with CC was smaller when adjusted for LD.
CONCLUSIONOur findings suggest that small maternal size, not poor maternal diet, in late gestation programs decreased arterial compliance in the adult offspring by affecting vessel size rather than vessel wall stiffness.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>17278968</pmid><doi>10.1097/HJH.0b013e328012135b</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Arteries - physiology Carotid Arteries - ultrastructure Cohort Studies Diabetes. Impaired glucose tolerance Elasticity Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fundamental and applied biological sciences. Psychology Humans Hypertension - etiology Infant, Low Birth Weight - physiology Infant, Newborn Male Malnutrition - complications Medical sciences Middle Aged Pregnancy Prenatal Exposure Delayed Effects Prenatal Nutritional Physiological Phenomena Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort |
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