Cytochalasin D abolishes the schistosomicidal activity of praziquantel

To test the hypothesis that calcium channels of schistosomes are the targets for the action of praziquantel, we subjected schistosomes in vitro to pharmacological agents capable of interfering with the functioning of calcium channels. After 1-h exposure to these agents, praziquantel was added and in...

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Veröffentlicht in:	Experimental parasitology 2007-04, Vol.115 (4), p.344-351
Hauptverfasser:	Pica-Mattoccia, Livia, Valle, Cristiana, Basso, Annalisa, Troiani, Anna Rita, Vigorosi, Fabio, Liberti, Piero, Festucci, Alfredo, Cioli, Donato
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin cytoskeleton Actins - drug effects Animals Biological and medical sciences Biomphalaria Bridged Bicyclo Compounds, Heterocyclic - pharmacology Calcium blockers Calcium Channel Blockers - pharmacology Calcium channels Calcium Channels - drug effects Cytochalasin D Cytochalasin D - pharmacology Cytoskeleton - drug effects Fundamental and applied biological sciences. Psychology Life cycle. Host-agent relationship. Pathogenesis Male Mice Nucleic Acid Synthesis Inhibitors - pharmacology Parasitic Sensitivity Tests Praziquantel Praziquantel - pharmacology Protozoa Schistosoma mansoni Schistosoma mansoni - drug effects Schistosomicides - pharmacology Thiazolidines - pharmacology Trematode
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