Childhood acute myelogenous leukaemia: Association between PRAME, apoptosis- and MDR-related gene expression

The gene PRAME (preferentially expressed antigen of melanoma) encodes an antigen recognised by autologous cytolytic T lymphocytes. The mRNA level of PRAME is used as a tumour marker due to its overexpression in various malignancies. Furthermore, it is known that the overexpression of genes encoding...

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Veröffentlicht in:	European journal of cancer (1990) 2006-11, Vol.42 (16), p.2807-2814
Hauptverfasser:	Goellner, Stefanie, Steinbach, Daniel, Schenk, Tino, Gruhn, Bernd, Zintl, Felix, Ramsay, Edward, Saluz, Hans P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease acute myelogenous leukaemia Adolescent AML Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Apoptosis Biological and medical sciences cDNA microarray Child Child, Preschool Differential gene expression Drug resistance Drug Resistance, Multiple - genetics Female Gene Expression Genes, MDR - genetics Humans Infant Infant, Newborn Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - pathology Male Medical sciences Microarray Analysis Pharmacology. Drug treatments Tumors Up-Regulation
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