Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity

The gradual accumulation of chronic lymphocytic leukemia (B-CLL) cells is presumed to derive from proliferation centers in lymph nodes and bone marrow. To what extent these cells possess the purported antiapoptotic phenotype of peripheral B-CLL cells is unknown. Recently, we have described that, in...

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Veröffentlicht in:	Blood 2007-02, Vol.109 (4), p.1660-1668
Hauptverfasser:	Smit, Laura A., Hallaert, Delfine Y.H., Spijker, René, de Goeij, Bart, Jaspers, Annelieke, Kater, Arnon P., van Oers, Marinus H.J., van Noesel, Carel J.M., Eldering, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Biological and medical sciences Bone Marrow - pathology Cell Survival Gene Expression Profiling Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Medical sciences Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - analysis Proto-Oncogene Proteins c-bcl-2 - analysis Tumor Cells, Cultured
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