Effects of the IGF-I/IGFBP-3 complex on GH and ghrelin nocturnal concentrations in low birth weight children
Summary Objective There is limited information regarding the effects of IGF‐I and/or IGFBP‐3 on circulating ghrelin concentrations. To determine the effects of IGF‐I on GH and ghrelin concentrations, we examined the GH and ghrelin nocturnal profiles before and after the administration of the IGF‐I/...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2006-11, Vol.65 (5), p.687-692 |
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| creator | Iñiguez, German Salazar, Teresa Roman, Rossana Avila, Alejandra Gunn, Ronald D. Cassorla, Fernando |
| description | Summary
Objective There is limited information regarding the effects of IGF‐I and/or IGFBP‐3 on circulating ghrelin concentrations. To determine the effects of IGF‐I on GH and ghrelin concentrations, we examined the GH and ghrelin nocturnal profiles before and after the administration of the IGF‐I/–IGFBP‐3 complex (Iplex™) to low birth weight children.
Design The children were studied on two separate occasions, the first under basal conditions, and the second time after the sc administration of 1 mg/kg of Iplex™ at 2100 h. Blood samples for determination of GH and ghrelin were obtained every 20 min between 2300 h and 0700 h, while the children were sleeping. In each patient, we calculated the mean GH and ghrelin area under the curve (GH AUC and GHR AUC), both under basal conditions and after the administration of the IGF‐I/IGFBP‐3 complex.
Setting The study was performed at a University Research Centre located at a General Hospital in Santiago, Chile.
Patients Twenty prepubertal children (11 boys and 9 girls), born after a full‐term pregnancy with a birth weight below 2·8 kg were studied at a mean ± SEM age of 7·3 ± 0·5 years (range 4–11 years). Their mean height was −1·8 ± 0·3 standard deviation score (SDS) and their mean BMI was 0·1 ± 0·2 SDS at the time of the study.
Main outcome and results Mean nocturnal GH AUC exhibited a significant decrease (2903 ± 185 vs 1860 ± 122 ng/ml min, P |
| doi_str_mv | 10.1111/j.1365-2265.2006.02650.x |
| format | Article |
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Objective There is limited information regarding the effects of IGF‐I and/or IGFBP‐3 on circulating ghrelin concentrations. To determine the effects of IGF‐I on GH and ghrelin concentrations, we examined the GH and ghrelin nocturnal profiles before and after the administration of the IGF‐I/–IGFBP‐3 complex (Iplex™) to low birth weight children.
Design The children were studied on two separate occasions, the first under basal conditions, and the second time after the sc administration of 1 mg/kg of Iplex™ at 2100 h. Blood samples for determination of GH and ghrelin were obtained every 20 min between 2300 h and 0700 h, while the children were sleeping. In each patient, we calculated the mean GH and ghrelin area under the curve (GH AUC and GHR AUC), both under basal conditions and after the administration of the IGF‐I/IGFBP‐3 complex.
Setting The study was performed at a University Research Centre located at a General Hospital in Santiago, Chile.
Patients Twenty prepubertal children (11 boys and 9 girls), born after a full‐term pregnancy with a birth weight below 2·8 kg were studied at a mean ± SEM age of 7·3 ± 0·5 years (range 4–11 years). Their mean height was −1·8 ± 0·3 standard deviation score (SDS) and their mean BMI was 0·1 ± 0·2 SDS at the time of the study.
Main outcome and results Mean nocturnal GH AUC exhibited a significant decrease (2903 ± 185 vs 1860 ± 122 ng/ml min, P < 0·01), whereas mean GHR AUC showed a significant increase after administration of the IGF‐I/IGFBP‐3 complex (68 ± 16 vs 288 ± 36 ng/ml min, P < 0·01).
Conclusions These findings indicate that the IGF‐I/IGFBP‐3 complex appears to have opposite effects on circulating GH and ghrelin concentrations in low birth weight children, suggesting that, in addition to its known negative feed‐back effect on GH, IGF‐I and/or IGFBP‐3 may have a positive feed‐back effect on ghrelin.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2006.02650.x</identifier><identifier>PMID: 17054474</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Area Under Curve ; Biological and medical sciences ; Child ; Endocrinopathies ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Ghrelin ; Growth Disorders - metabolism ; Growth Hormone - blood ; Humans ; Infant, Low Birth Weight - metabolism ; Infant, Newborn ; Insulin-Like Growth Factor Binding Protein 3 - pharmacology ; Insulin-Like Growth Factor I - pharmacology ; Medical sciences ; Multiprotein Complexes - pharmacology ; Peptide Hormones - blood ; Secretory Rate ; Statistics, Nonparametric ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2006-11, Vol.65 (5), p.687-692</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4350-ed6ed8fcc738085e3b834b7920536dfb0c7e008409eeedc5f9c689e62d2b1fe73</citedby><cites>FETCH-LOGICAL-c4350-ed6ed8fcc738085e3b834b7920536dfb0c7e008409eeedc5f9c689e62d2b1fe73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2006.02650.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2006.02650.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18213138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17054474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iñiguez, German</creatorcontrib><creatorcontrib>Salazar, Teresa</creatorcontrib><creatorcontrib>Roman, Rossana</creatorcontrib><creatorcontrib>Avila, Alejandra</creatorcontrib><creatorcontrib>Gunn, Ronald D.</creatorcontrib><creatorcontrib>Cassorla, Fernando</creatorcontrib><title>Effects of the IGF-I/IGFBP-3 complex on GH and ghrelin nocturnal concentrations in low birth weight children</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective There is limited information regarding the effects of IGF‐I and/or IGFBP‐3 on circulating ghrelin concentrations. To determine the effects of IGF‐I on GH and ghrelin concentrations, we examined the GH and ghrelin nocturnal profiles before and after the administration of the IGF‐I/–IGFBP‐3 complex (Iplex™) to low birth weight children.
Design The children were studied on two separate occasions, the first under basal conditions, and the second time after the sc administration of 1 mg/kg of Iplex™ at 2100 h. Blood samples for determination of GH and ghrelin were obtained every 20 min between 2300 h and 0700 h, while the children were sleeping. In each patient, we calculated the mean GH and ghrelin area under the curve (GH AUC and GHR AUC), both under basal conditions and after the administration of the IGF‐I/IGFBP‐3 complex.
Setting The study was performed at a University Research Centre located at a General Hospital in Santiago, Chile.
Patients Twenty prepubertal children (11 boys and 9 girls), born after a full‐term pregnancy with a birth weight below 2·8 kg were studied at a mean ± SEM age of 7·3 ± 0·5 years (range 4–11 years). Their mean height was −1·8 ± 0·3 standard deviation score (SDS) and their mean BMI was 0·1 ± 0·2 SDS at the time of the study.
Main outcome and results Mean nocturnal GH AUC exhibited a significant decrease (2903 ± 185 vs 1860 ± 122 ng/ml min, P < 0·01), whereas mean GHR AUC showed a significant increase after administration of the IGF‐I/IGFBP‐3 complex (68 ± 16 vs 288 ± 36 ng/ml min, P < 0·01).
Conclusions These findings indicate that the IGF‐I/IGFBP‐3 complex appears to have opposite effects on circulating GH and ghrelin concentrations in low birth weight children, suggesting that, in addition to its known negative feed‐back effect on GH, IGF‐I and/or IGFBP‐3 may have a positive feed‐back effect on ghrelin.</description><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Endocrinopathies</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin</subject><subject>Growth Disorders - metabolism</subject><subject>Growth Hormone - blood</subject><subject>Humans</subject><subject>Infant, Low Birth Weight - metabolism</subject><subject>Infant, Newborn</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - pharmacology</subject><subject>Insulin-Like Growth Factor I - pharmacology</subject><subject>Medical sciences</subject><subject>Multiprotein Complexes - pharmacology</subject><subject>Peptide Hormones - blood</subject><subject>Secretory Rate</subject><subject>Statistics, Nonparametric</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv0zAUxy0EYqXwFZAvcEv2EieOc-AAVdd1GoMDiKPlOM9Liut0dqp23x5nrbYrlmU_6f3-z9aPEJpBmsV1uUkzxsskz3mZ5gA8hVhBenxFZs-N12QGDCABzosL8i6EDQCUAqq35CKroCyKqpgRuzQG9RjoYOjYIV2vrpL1ZTy__UwY1cN2Z_FIB0dX11S5lt53Hm3vqBv0uPdO2cg4jW70auwHF2js2eFAm96PHT1gf9-NVHe9bT269-SNUTbgh_M9J7-vlr8W18ntj9V68fU20QUrIcGWYyuM1hUTIEpkjWBFU9U5lIy3pgFdIYAooEbEVpem1lzUyPM2bzKDFZuTz6e5Oz887DGMctsHjdYqh8M-yEgLxuO0OREnUPshBI9G7ny_Vf5RZiAn03IjJ6FyEion0_LJtDzG6MfzG_tmi-1L8Kw2Ap_OgApaWeOV03144USesYyJyH05cYfe4uN_f0AulndTFfPJKd-HEY_PeeX_Sl6xqpR_7lby5nvN4gbJ2D_uM6ed</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Iñiguez, German</creator><creator>Salazar, Teresa</creator><creator>Roman, Rossana</creator><creator>Avila, Alejandra</creator><creator>Gunn, Ronald D.</creator><creator>Cassorla, Fernando</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Effects of the IGF-I/IGFBP-3 complex on GH and ghrelin nocturnal concentrations in low birth weight children</title><author>Iñiguez, German ; Salazar, Teresa ; Roman, Rossana ; Avila, Alejandra ; Gunn, Ronald D. ; Cassorla, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4350-ed6ed8fcc738085e3b834b7920536dfb0c7e008409eeedc5f9c689e62d2b1fe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Endocrinopathies</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin</topic><topic>Growth Disorders - metabolism</topic><topic>Growth Hormone - blood</topic><topic>Humans</topic><topic>Infant, Low Birth Weight - metabolism</topic><topic>Infant, Newborn</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - pharmacology</topic><topic>Insulin-Like Growth Factor I - pharmacology</topic><topic>Medical sciences</topic><topic>Multiprotein Complexes - pharmacology</topic><topic>Peptide Hormones - blood</topic><topic>Secretory Rate</topic><topic>Statistics, Nonparametric</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iñiguez, German</creatorcontrib><creatorcontrib>Salazar, Teresa</creatorcontrib><creatorcontrib>Roman, Rossana</creatorcontrib><creatorcontrib>Avila, Alejandra</creatorcontrib><creatorcontrib>Gunn, Ronald D.</creatorcontrib><creatorcontrib>Cassorla, Fernando</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iñiguez, German</au><au>Salazar, Teresa</au><au>Roman, Rossana</au><au>Avila, Alejandra</au><au>Gunn, Ronald D.</au><au>Cassorla, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the IGF-I/IGFBP-3 complex on GH and ghrelin nocturnal concentrations in low birth weight children</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2006-11</date><risdate>2006</risdate><volume>65</volume><issue>5</issue><spage>687</spage><epage>692</epage><pages>687-692</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective There is limited information regarding the effects of IGF‐I and/or IGFBP‐3 on circulating ghrelin concentrations. To determine the effects of IGF‐I on GH and ghrelin concentrations, we examined the GH and ghrelin nocturnal profiles before and after the administration of the IGF‐I/–IGFBP‐3 complex (Iplex™) to low birth weight children.
Design The children were studied on two separate occasions, the first under basal conditions, and the second time after the sc administration of 1 mg/kg of Iplex™ at 2100 h. Blood samples for determination of GH and ghrelin were obtained every 20 min between 2300 h and 0700 h, while the children were sleeping. In each patient, we calculated the mean GH and ghrelin area under the curve (GH AUC and GHR AUC), both under basal conditions and after the administration of the IGF‐I/IGFBP‐3 complex.
Setting The study was performed at a University Research Centre located at a General Hospital in Santiago, Chile.
Patients Twenty prepubertal children (11 boys and 9 girls), born after a full‐term pregnancy with a birth weight below 2·8 kg were studied at a mean ± SEM age of 7·3 ± 0·5 years (range 4–11 years). Their mean height was −1·8 ± 0·3 standard deviation score (SDS) and their mean BMI was 0·1 ± 0·2 SDS at the time of the study.
Main outcome and results Mean nocturnal GH AUC exhibited a significant decrease (2903 ± 185 vs 1860 ± 122 ng/ml min, P < 0·01), whereas mean GHR AUC showed a significant increase after administration of the IGF‐I/IGFBP‐3 complex (68 ± 16 vs 288 ± 36 ng/ml min, P < 0·01).
Conclusions These findings indicate that the IGF‐I/IGFBP‐3 complex appears to have opposite effects on circulating GH and ghrelin concentrations in low birth weight children, suggesting that, in addition to its known negative feed‐back effect on GH, IGF‐I and/or IGFBP‐3 may have a positive feed‐back effect on ghrelin.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17054474</pmid><doi>10.1111/j.1365-2265.2006.02650.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Area Under Curve Biological and medical sciences Child Endocrinopathies Follow-Up Studies Fundamental and applied biological sciences. Psychology Ghrelin Growth Disorders - metabolism Growth Hormone - blood Humans Infant, Low Birth Weight - metabolism Infant, Newborn Insulin-Like Growth Factor Binding Protein 3 - pharmacology Insulin-Like Growth Factor I - pharmacology Medical sciences Multiprotein Complexes - pharmacology Peptide Hormones - blood Secretory Rate Statistics, Nonparametric Vertebrates: endocrinology |
| title | Effects of the IGF-I/IGFBP-3 complex on GH and ghrelin nocturnal concentrations in low birth weight children |
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