Induction of antigen-specific tolerance by intrathymic injection of lentiviral vectors

Immune tolerance to self-antigens is established during lymphocyte differentiation in the thymus, but a simple means to induce antigen-specific tolerance in the thymus is still elusive. We show here that intrathymic injection of a lentiviral vector expressing the hemagglutinin antigen (HA) in TCR-HA...

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Veröffentlicht in:	Blood 2006-11, Vol.108 (9), p.2972-2978
Hauptverfasser:	Marodon, Gilles, Fisson, Sylvain, Levacher, Béatrice, Fabre, Monique, Salomon, Benoît L., Klatzmann, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Diabetes Mellitus, Experimental - prevention & control Flow Cytometry Fundamental and applied biological sciences. Psychology Gene therapy Genetic Vectors Health. Pharmaceutical industry Hemagglutination Tests Humans Immune Tolerance Industrial applications and implications. Economical aspects Interleukin-2 Receptor alpha Subunit - immunology Lentivirus Leukocyte Common Antigens - immunology Lymphocytes - immunology Medical sciences Mice Mice, Transgenic Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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