Interaction of leptospires with murine microglial cells
Leptospires, the agents of leptospirosis, exert tropism for the central nervous system, in the course of mammal infection. We evaluated the interaction between murine microglial cells and strains of pathogenic L. interrogans leptospires and non-pathogenic L. biflexa leptospires, mainly by flow cytom...
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| Veröffentlicht in: | The New microbiologica 2006-07, Vol.29 (3), p.193-199 |
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| creator | Cinco, Marina Domenis, Rossana Perticarari, Sandra Presani, Gianni Marangoni, Antonella Blasi, Elisabetta |
| description | Leptospires, the agents of leptospirosis, exert tropism for the central nervous system, in the course of mammal infection. We evaluated the interaction between murine microglial cells and strains of pathogenic L. interrogans leptospires and non-pathogenic L. biflexa leptospires, mainly by flow cytometric assays. In the absence of opsonic conditions microglia are capable of ingesting--even quite slowly--the spirochetes and killing the non-pathogenic strain. The adhesion to microglia, which is quick and relevant for all the strains, does not involve the CR3 integrin receptor. These findings suggest that the murine microglia--in non opsonic conditions in vitro--do not effectively clear the pathogenic leptospires. |
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These findings suggest that the murine microglia--in non opsonic conditions in vitro--do not effectively clear the pathogenic leptospires.</description><subject>Animals</subject><subject>Bacterial Adhesion - physiology</subject><subject>Cell Line</subject><subject>Flow Cytometry</subject><subject>Leptospira</subject><subject>Leptospira - pathogenicity</subject><subject>Macrophage-1 Antigen - physiology</subject><subject>Mice</subject><subject>Microglia - immunology</subject><subject>Microglia - microbiology</subject><subject>Phagocytosis</subject><issn>1121-7138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAURT2AaFX6F5Antki2E_vZI6r4qFSpC8yREz-DkRMHOxHi31NEmbnLXY6Oru4FWXMueAW81iuyLeWdnaIkF0ZckRUHJjVotSawH2fMtp9DGmnyNOI0pzKFjIV-hvmNDksOI9Ih9Dm9xmAj7THGck0uvY0Ft-fekJeH--fdU3U4Pu53d4dqEg2bK991tdLGI3AnoelYZ6GRTqBTnivHAQWgaSxrmPY1OCOVcQq1Nk4D77DekNtf75TTx4JlbodQfhbYEdNS2pNc11zDv6BgCpTh8gTenMGlG9C1Uw6DzV_t3yf1N2qSXO4</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Cinco, Marina</creator><creator>Domenis, Rossana</creator><creator>Perticarari, Sandra</creator><creator>Presani, Gianni</creator><creator>Marangoni, Antonella</creator><creator>Blasi, Elisabetta</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7TK</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Interaction of leptospires with murine microglial cells</title><author>Cinco, Marina ; Domenis, Rossana ; Perticarari, Sandra ; Presani, Gianni ; Marangoni, Antonella ; Blasi, Elisabetta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-fbb3689fe71d574b0ba745d2ed6f16d17e27e94a0408f37d9569d6e889d871be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Bacterial Adhesion - physiology</topic><topic>Cell Line</topic><topic>Flow Cytometry</topic><topic>Leptospira</topic><topic>Leptospira - pathogenicity</topic><topic>Macrophage-1 Antigen - physiology</topic><topic>Mice</topic><topic>Microglia - immunology</topic><topic>Microglia - microbiology</topic><topic>Phagocytosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cinco, Marina</creatorcontrib><creatorcontrib>Domenis, Rossana</creatorcontrib><creatorcontrib>Perticarari, Sandra</creatorcontrib><creatorcontrib>Presani, Gianni</creatorcontrib><creatorcontrib>Marangoni, Antonella</creatorcontrib><creatorcontrib>Blasi, Elisabetta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The New microbiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cinco, Marina</au><au>Domenis, Rossana</au><au>Perticarari, Sandra</au><au>Presani, Gianni</au><au>Marangoni, Antonella</au><au>Blasi, Elisabetta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of leptospires with murine microglial cells</atitle><jtitle>The New microbiologica</jtitle><addtitle>New Microbiol</addtitle><date>2006-07</date><risdate>2006</risdate><volume>29</volume><issue>3</issue><spage>193</spage><epage>199</epage><pages>193-199</pages><issn>1121-7138</issn><abstract>Leptospires, the agents of leptospirosis, exert tropism for the central nervous system, in the course of mammal infection. 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| ispartof | The New microbiologica, 2006-07, Vol.29 (3), p.193-199 |
| issn | 1121-7138 |
| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Bacterial Adhesion - physiology Cell Line Flow Cytometry Leptospira Leptospira - pathogenicity Macrophage-1 Antigen - physiology Mice Microglia - immunology Microglia - microbiology Phagocytosis |
| title | Interaction of leptospires with murine microglial cells |
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